棘球绦虫卵被人误食后,主要在肝肺两大脏器长成棘球蚴(包虫囊肿),并随其逐渐长大致使肝肺形态发生改变,这些改变可通过影像学诊断技术得以显示,由于临床应用 B 超技术诊断人体包虫病取得显著成就,因而也被推荐用于人群包虫病现场筛查....棘球绦虫卵被人误食后,主要在肝肺两大脏器长成棘球蚴(包虫囊肿),并随其逐渐长大致使肝肺形态发生改变,这些改变可通过影像学诊断技术得以显示,由于临床应用 B 超技术诊断人体包虫病取得显著成就,因而也被推荐用于人群包虫病现场筛查.作者认为,B 超诊断技术应用于人群包虫病普查在许多方面优于血清学检查。B 超对人体包虫病诊断准确率高达90%以上,可现场获得检查结果,较真实地反映居民患病状况。肝脏是包虫囊肿好发部位,而腹部 B 超探查肝包虫病,对于鉴别肝内囊性占位及右上腹囊性占位病变对肝脏的关系有肯定意义。B 超诊断技术无痛无创伤,愿为公众接受,有助于推进卫生教育;能够发现早期包虫病患者以利及早就医治疗,也有助于对术后病人的随访观察。包虫病血清流行病学调查结合 B 超诊断技术,不仅能更准确地估计患病率水平,也有助于实验研究。故 B 超诊断技术用于人体包虫病的现场筛查是有效可行的。展开更多
OBJECTIVE: To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis. METHODS: Two regimens of AbzE (10 mg.kg(-1).d(-1) and 12.5 mg.kg(-1).d(-1)) were g...OBJECTIVE: To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis. METHODS: Two regimens of AbzE (10 mg.kg(-1).d(-1) and 12.5 mg.kg(-1).d(-1)) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1 - 4 years after the cessation of therapy. RESULTS: At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.1%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg.kg(-1).d(-1) for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results. CONCLUSIONS: AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.展开更多
文摘棘球绦虫卵被人误食后,主要在肝肺两大脏器长成棘球蚴(包虫囊肿),并随其逐渐长大致使肝肺形态发生改变,这些改变可通过影像学诊断技术得以显示,由于临床应用 B 超技术诊断人体包虫病取得显著成就,因而也被推荐用于人群包虫病现场筛查.作者认为,B 超诊断技术应用于人群包虫病普查在许多方面优于血清学检查。B 超对人体包虫病诊断准确率高达90%以上,可现场获得检查结果,较真实地反映居民患病状况。肝脏是包虫囊肿好发部位,而腹部 B 超探查肝包虫病,对于鉴别肝内囊性占位及右上腹囊性占位病变对肝脏的关系有肯定意义。B 超诊断技术无痛无创伤,愿为公众接受,有助于推进卫生教育;能够发现早期包虫病患者以利及早就医治疗,也有助于对术后病人的随访观察。包虫病血清流行病学调查结合 B 超诊断技术,不仅能更准确地估计患病率水平,也有助于实验研究。故 B 超诊断技术用于人体包虫病的现场筛查是有效可行的。
基金ThisstudywassupportedbytheNinthNationalFive yearPlanKeyResearchProject (No .96 90 6 0 4 0 9)
文摘OBJECTIVE: To evaluate the clinical efficacy of a new formulation of albendazole emulsion (AbzE) in cases of liver cystic hydatidosis. METHODS: Two regimens of AbzE (10 mg.kg(-1).d(-1) and 12.5 mg.kg(-1).d(-1)) were given to 212 patients with liver cystic hydatidosis in courses ranging from 3 months to more than one year. Assessment of drug efficacy was essentially based on imaging signs with ultrasonography as the main tool. Assessments were performed at the end of different courses and in the follow-up study of 1 - 4 years after the cessation of therapy. RESULTS: At the end of therapeutic courses, the overall cure rate of the 212 cases was 74.5%, with a 99.1% effective rate. In the follow-up study, the cure rate was 83.1%, effective rate was 89.3%, ineffective rate was 0.6%, and recurrence rate was 10.2%. The highest cure rate was observed in cases receiving AbzE 12.5 mg.kg(-1).d(-1) for 9 months. Retreatment of recurrent cases with AbzE obtained satisfactory results. CONCLUSIONS: AbzE surpassed other currently used antihydatidosis drugs or formulations with its promising efficacy and mild side effects, and could be recommended as a drug of choice in the treatment of cystic hydatidosis.
