From the methanol extract of the whole plant of Schnabelia oligophylla Hand.-Mazz. (Lamiaceae), a new cyclic octopeptide, named schnabepeptide (1), was isolated by silica gel chromatography. Its structure was elucidat...From the methanol extract of the whole plant of Schnabelia oligophylla Hand.-Mazz. (Lamiaceae), a new cyclic octopeptide, named schnabepeptide (1), was isolated by silica gel chromatography. Its structure was elucidated by spectroscopic analyses and the absolute configuration of the amino acid units, except for proline and glycine, were assigned by chiral HPLC analysis. Bio-assay showed that schnabepeptide (1) exhibited an immunosuppression activity on T/B lymphocytes. Along with the new compound, seven known compounds, octadeca-9, 16-dioxo-10(E),12(Z),14(E)-trienoic acid (2), 12, 16-epoxy-11, 14-dihydroxy-17( 15-->16), 18 (4-->3)-diabeo-abieta-3,5,8,11,13,15-hexene-2, 7-dione (teuvincenone F, 3), abscisic acid (4), beta -sitosterol (5), daucosterol (6), stigmasteryl 3-O-beta -D-glucopyranoside (7) and palmitic acid (8), were also isolated from this plant.展开更多
Aim To study the chemical constituents of seeds of Herpetospermum caudigerum. Methods Column chromatography was used in the isolation procedure, and the structure was elucidated by spectral data, whose pharmacologic a...Aim To study the chemical constituents of seeds of Herpetospermum caudigerum. Methods Column chromatography was used in the isolation procedure, and the structure was elucidated by spectral data, whose pharmacologic activity was assayed in vitro. Results A new compound named herpetin was isolated, whose structure was determined to be 3-benzofuran methanol-2, 3-dihydm-2-（4- hydroxy-3-methoxyphenyl ）-4-methoxy-6-[ tetrahydm-2-（ 3-hydroxy-4-methoxyphenyl ）-3-methanol ]-2- furanmethyl, showed significant inhibitory effects on HBV-DNA and the replication and expression of HBsAg and HBeAg. Conclusion Herpetin offers wide research and development prospect.展开更多
In this paper, a finite prism element procedure is presented, and a new infinite prism element for modelling the semi infinite domain boundary condition is developed to expedite the (3D) calculations in a more accur...In this paper, a finite prism element procedure is presented, and a new infinite prism element for modelling the semi infinite domain boundary condition is developed to expedite the (3D) calculations in a more accurate way for the far stress field to the pile. It has been taken into account that the soil is restrained by the pile cap, and the relative displacement happens between the pile and the soil. Revised Cambridge model is incoporated in the procedure for modelling elasto plastic behavior of the soil. In this paper, the single long friction pile with a pile cap and soil system are analyzed. The proper load displacement curve and frictional resistance distribution curve are obtained. The results can provide the basis for design and calculation of the long piled foundation.展开更多
The authors select different grain size samples from granitic body in Weishan, central Hunan, to conduct mylonitization experiments under high temperature (HT) and high pressure (HP), by which the temperature and pres...The authors select different grain size samples from granitic body in Weishan, central Hunan, to conduct mylonitization experiments under high temperature (HT) and high pressure (HP), by which the temperature and pressure conditions of mylonitization and microstructures of deformation have been obtained. Through the transmission electron microscopy (TEM) observations of experimental mylonite, we calculate its dislocation density (D), differential rheological stress (Pd) and speed rate of strain (Rs): 3.20x109/cm2, 139.32 MPa and 6.39x10-10/s respectively. The results are in the same magnitude-order with those of natural mylonite from fault zones. By comparison and analysis of chemical compositions and microstructures of different structural environments, the authors establish approximate rheological parameters related to shallow structural level and also suggest the multiple rheological properties and total trend from deep structural level to shallow structural level.展开更多
文摘From the methanol extract of the whole plant of Schnabelia oligophylla Hand.-Mazz. (Lamiaceae), a new cyclic octopeptide, named schnabepeptide (1), was isolated by silica gel chromatography. Its structure was elucidated by spectroscopic analyses and the absolute configuration of the amino acid units, except for proline and glycine, were assigned by chiral HPLC analysis. Bio-assay showed that schnabepeptide (1) exhibited an immunosuppression activity on T/B lymphocytes. Along with the new compound, seven known compounds, octadeca-9, 16-dioxo-10(E),12(Z),14(E)-trienoic acid (2), 12, 16-epoxy-11, 14-dihydroxy-17( 15-->16), 18 (4-->3)-diabeo-abieta-3,5,8,11,13,15-hexene-2, 7-dione (teuvincenone F, 3), abscisic acid (4), beta -sitosterol (5), daucosterol (6), stigmasteryl 3-O-beta -D-glucopyranoside (7) and palmitic acid (8), were also isolated from this plant.
文摘Aim To study the chemical constituents of seeds of Herpetospermum caudigerum. Methods Column chromatography was used in the isolation procedure, and the structure was elucidated by spectral data, whose pharmacologic activity was assayed in vitro. Results A new compound named herpetin was isolated, whose structure was determined to be 3-benzofuran methanol-2, 3-dihydm-2-（4- hydroxy-3-methoxyphenyl ）-4-methoxy-6-[ tetrahydm-2-（ 3-hydroxy-4-methoxyphenyl ）-3-methanol ]-2- furanmethyl, showed significant inhibitory effects on HBV-DNA and the replication and expression of HBsAg and HBeAg. Conclusion Herpetin offers wide research and development prospect.
文摘In this paper, a finite prism element procedure is presented, and a new infinite prism element for modelling the semi infinite domain boundary condition is developed to expedite the (3D) calculations in a more accurate way for the far stress field to the pile. It has been taken into account that the soil is restrained by the pile cap, and the relative displacement happens between the pile and the soil. Revised Cambridge model is incoporated in the procedure for modelling elasto plastic behavior of the soil. In this paper, the single long friction pile with a pile cap and soil system are analyzed. The proper load displacement curve and frictional resistance distribution curve are obtained. The results can provide the basis for design and calculation of the long piled foundation.
基金the National Natural Science Foundation of China (Grant No. 49972069), State Key Lab of Southwestern Petroleum Institute and Geomechanics Institute, CAGS.
文摘The authors select different grain size samples from granitic body in Weishan, central Hunan, to conduct mylonitization experiments under high temperature (HT) and high pressure (HP), by which the temperature and pressure conditions of mylonitization and microstructures of deformation have been obtained. Through the transmission electron microscopy (TEM) observations of experimental mylonite, we calculate its dislocation density (D), differential rheological stress (Pd) and speed rate of strain (Rs): 3.20x109/cm2, 139.32 MPa and 6.39x10-10/s respectively. The results are in the same magnitude-order with those of natural mylonite from fault zones. By comparison and analysis of chemical compositions and microstructures of different structural environments, the authors establish approximate rheological parameters related to shallow structural level and also suggest the multiple rheological properties and total trend from deep structural level to shallow structural level.
