Aquilaria sinensis(Thymelaeaceae)is widely cultivated in southern China for its significant medicinal usage.The resinous wood,the most used part of the plant as traditional Chinese medicine(TCM),locally called“Chen X...Aquilaria sinensis(Thymelaeaceae)is widely cultivated in southern China for its significant medicinal usage.The resinous wood,the most used part of the plant as traditional Chinese medicine(TCM),locally called“Chen Xiang(沉香)”or Chinese agarwood,has been traditionally used for the treatment of circulatory disorders,abdominal pain,vomiting,and dyspnea.Till date,over 249 compounds have been isolated and identified from this plant.A range of bioactivities,including α-glucosidase inhibitory effects,anti-inflammatory,cytotoxicity,neuroprotective,anti-neuroinflammatory,antimicrobial and acetylcholinesterase inhibitory effects,along with some of the pharmacological mechanisms have been reported for the pure compounds or extracts of Aquilaria sinensis.For the purpose of quality control and clinical safety of drug usage,modern analytical instruments and chemical analysis methods have been applied for analyses of Aquilaria sinensis.In order to comprehensively understand the medicinal application and to fully utilize the plant,a literature search on the herb based on databases including SciFinder,Web of Science,Pubmed,Google Scholar and others was performed and the information regarding to the phytochemistry investigations,pharmacological studies and quality control was summarized in this paper.展开更多
Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years.Chuanxiong Rhizoma is composed of volatile oils,phthalide lactones,phenolic acids,polysaccharides and other compounds.To date,more tha...Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years.Chuanxiong Rhizoma is composed of volatile oils,phthalide lactones,phenolic acids,polysaccharides and other compounds.To date,more than 149 compounds in Chuanxiong Rhizoma have been isolated and identified,and some of them have been reported to possess promising biological properties on cardiovascular and central nervous system disorders besides their anti-cancer and antioxidant effects.Modulation of inflammatory mediators and apoptotic factors are believed to contribute to its bioactivities.Analytical methods,such as HPLC,GC and UPLC,are employed for qualitative evaluation of Chuanxiong Rhizoma.In this work,harvest period,growing habitat,processing method and storage,which can affect the quality of Chuanxiong Rhizoma,were also discussed.Comprehensive quality control methods should be developed to ensure the safety,quality and efficacy use of Chuanxiong Rhizoma.Herein,we collected and analyzed the literature of Chuanxiong Rhizoma published on CNKI,ScienceDirect,Springer link,Wiley and PubMed in past two decades,and up-to-date information of Chuanxiong Rhizoma was provided in this paper.We suggested ligustilide,butylidenephthalide and total senkyunolides as the chemical markers to evaluate the quality of Chuanxiong Rhizoma.Additionally,the influences of soil conditions and processing methods on Chuanxiong Rhizoma as future research perspectives should also be further assessed.展开更多
基金support from the Administration of Traditional Chinese Medicine of Hunan Province(201673)Hunan Province Universities 2011 Collaborative Innovation Center of Protection and Utilization of Hu-xiang Chinese Medicine Resources(HXZY-2015-005 and HXZY-2015-012)+1 种基金the State Key Subject of TCM Diagnostics in Hunan University of Chinese Medicine(2015ZYZD06)Hunan Provincial Key Laboratory of Dong Medicine(2015TP1020-02)
文摘Aquilaria sinensis(Thymelaeaceae)is widely cultivated in southern China for its significant medicinal usage.The resinous wood,the most used part of the plant as traditional Chinese medicine(TCM),locally called“Chen Xiang(沉香)”or Chinese agarwood,has been traditionally used for the treatment of circulatory disorders,abdominal pain,vomiting,and dyspnea.Till date,over 249 compounds have been isolated and identified from this plant.A range of bioactivities,including α-glucosidase inhibitory effects,anti-inflammatory,cytotoxicity,neuroprotective,anti-neuroinflammatory,antimicrobial and acetylcholinesterase inhibitory effects,along with some of the pharmacological mechanisms have been reported for the pure compounds or extracts of Aquilaria sinensis.For the purpose of quality control and clinical safety of drug usage,modern analytical instruments and chemical analysis methods have been applied for analyses of Aquilaria sinensis.In order to comprehensively understand the medicinal application and to fully utilize the plant,a literature search on the herb based on databases including SciFinder,Web of Science,Pubmed,Google Scholar and others was performed and the information regarding to the phytochemistry investigations,pharmacological studies and quality control was summarized in this paper.
基金The 12thinnovation activity plan-of undergraduates in the Shanghai University of Traditional Chinese Medicine(Grant No.2019SHUTCM060)the Natural Science Foundation of Shanghai(Grant No.19ZR1457700)+1 种基金2020 New Agricultural Science Research and Reform Practice Project of the Ministry of Education2020 Key Undergraduate Education Reform Project of Shanghai Colleges。
文摘Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years.Chuanxiong Rhizoma is composed of volatile oils,phthalide lactones,phenolic acids,polysaccharides and other compounds.To date,more than 149 compounds in Chuanxiong Rhizoma have been isolated and identified,and some of them have been reported to possess promising biological properties on cardiovascular and central nervous system disorders besides their anti-cancer and antioxidant effects.Modulation of inflammatory mediators and apoptotic factors are believed to contribute to its bioactivities.Analytical methods,such as HPLC,GC and UPLC,are employed for qualitative evaluation of Chuanxiong Rhizoma.In this work,harvest period,growing habitat,processing method and storage,which can affect the quality of Chuanxiong Rhizoma,were also discussed.Comprehensive quality control methods should be developed to ensure the safety,quality and efficacy use of Chuanxiong Rhizoma.Herein,we collected and analyzed the literature of Chuanxiong Rhizoma published on CNKI,ScienceDirect,Springer link,Wiley and PubMed in past two decades,and up-to-date information of Chuanxiong Rhizoma was provided in this paper.We suggested ligustilide,butylidenephthalide and total senkyunolides as the chemical markers to evaluate the quality of Chuanxiong Rhizoma.Additionally,the influences of soil conditions and processing methods on Chuanxiong Rhizoma as future research perspectives should also be further assessed.
