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大豆蛋白降低人体血浆胆固醇浓度的作用途径(英文)
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作者 徐超 王晓红 +1 位作者 郭连营 周波 《中国临床康复》 CSCD 北大核心 2005年第43期167-170,共4页
背景:多项实验表明同酪蛋白相比,大豆蛋白在动物包括人体内可以降低血浆胆固醇浓度,但其作用途径尚未阐明。目的:探讨摄入大豆蛋白后,人体血浆胆固醇浓度降低的可能作用途径。设计:观察对比实验。单位:沈阳医学院预防医学系营养与食品... 背景:多项实验表明同酪蛋白相比,大豆蛋白在动物包括人体内可以降低血浆胆固醇浓度,但其作用途径尚未阐明。目的:探讨摄入大豆蛋白后,人体血浆胆固醇浓度降低的可能作用途径。设计:观察对比实验。单位:沈阳医学院预防医学系营养与食品卫生学教研室。对象:实验于2002-03/05在沈阳医学院预防医学系营养与食品卫生学实验室完成。选择沈阳医学院健康大学生20名,男女各半,均自愿参加实验,并得到签名的书面同意书。年龄(21±1)岁,体质量指数为(22.3±3.0)kg/m2,血浆总胆固醇浓度在正常范围。将实验对象分为两组,既酪蛋白组和大豆蛋白组,每组10名。方法:依据中国营养学会1999年制定的《中国居民平衡膳食宝塔》和学生餐厅食谱编制基础膳食食谱。在摄入相同基础膳食的基础上,酪蛋白组和大豆蛋白组每人摄入酪蛋白和大豆蛋白30g/d,共摄入14d。在实验开始和结束时,测量两组实验对象的体质量,并采血测定血浆总胆固醇浓度;在实验结束前3d,收集每人的粪便,测定粪钙、磷、镁、脂类和胆汁酸含量,并进行比较分析。主要观察指标:①两组实验对象实验期间血浆总胆固醇浓度。②两组实验对象实验期间粪钙、磷、镁、脂类和胆汁酸排出量及相关和回归分析结果。结果:大豆蛋白组1名实验对象由于交通事故退出实验,酪蛋白组1名实验对象因对酪蛋白不耐受退出实验。两组均有9名实验对象进入结果分析。①两组实验对象实验期间血浆总胆固醇浓度比较:与实验开始时相比,实验14d后酪蛋白组血浆总胆固醇浓度升高了11%犤(3.7±0.47,4.1±0.61)mmol/L(Z=-2.668,P<0.01)犦,而大豆蛋白组仅升高了6%(P>0.05)。②两组实验对象实验期间粪钙、磷、镁、脂类和胆汁酸排出量比较:同酪蛋白组相比,大豆蛋白组的粪钙、磷和镁的排出量均明显增加,分别增加了60.3%,44.1%和55.0%(P<0.05~0.01);粪脂类和胆汁酸分别增加了33.6%和45.3%。③相关和回归分析:粪胆汁酸排出量同粪钙、磷、镁和脂类排出量呈显著正相关(t=3.173,3.448,2.411,2.122,P<0.05)。结论:大豆蛋白降低人体血浆胆固醇浓度的可能途径是增加了粪钙、磷、镁和胆汁酸的排出量。 展开更多
关键词 黄豆 固醇 植物蛋白质 胆汁酸和盐
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茶叶抗肿瘤抗致突变作用研究概况(综述)
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作者 张效良 范维珂 《川北医学院学报》 CAS 1989年第4期71-73,共3页
进入本世纪的八十多年来,人类恶性肿瘤的死亡率猛增了三倍。肿瘤已成为人类死亡原因的第二位。因此,预防肿瘤发生的研究愈来愈为人们所关注。寻找抗肿瘤、抗致突变的物质已为许多学者所重视业已发现,人类食物中有许多具有抗癌作用的物... 进入本世纪的八十多年来,人类恶性肿瘤的死亡率猛增了三倍。肿瘤已成为人类死亡原因的第二位。因此,预防肿瘤发生的研究愈来愈为人们所关注。寻找抗肿瘤、抗致突变的物质已为许多学者所重视业已发现,人类食物中有许多具有抗癌作用的物质。如维生素 A、B—胡萝卜素、维生素 E、C、吲哚、酚类、硒化物、芳香异硫氰酸、甲基化黄酮、香豆素、植物固醇类、谷胱甘肽、蛋白酶抑制剂等等。近年,有资料报道,茶叶亦具有抗癌和抗致突变作用。茶叶是世界三大无酒精性饮料之一,据估计,全世界约有一半人口饮茶。 展开更多
关键词 致突变作用 茶叶水 植物固醇类 肿瘤预防 死亡原因 蛋白酶抑制剂 硒化物 食物 黄酮化合物 突变性
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Is kinase activity essential for biological functions of BRI1? 被引量:10
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作者 Weihui Xu Juan Huang +2 位作者 Baohua Li Jiayang Li Yonghong Wang 《Cell Research》 SCIE CAS CSCD 2008年第4期472-478,共7页
Brassinosteroids (BRs) are a major group of plant hormones that regulate plant growth and development. BRI1, a protein localized to the plasma membrane, functions as a BR receptor and it has been proposed that its k... Brassinosteroids (BRs) are a major group of plant hormones that regulate plant growth and development. BRI1, a protein localized to the plasma membrane, functions as a BR receptor and it has been proposed that its kinase activity has an essential role in BR-regulated plant growth and development. Here we report the isolation and molecular characterization of a new allele of bril, bril-301, which shows moderate morphological phenotypes and a reduced response to BRs under normal growth conditions. Sequence analysis identified a two-base alteration from GG to AT, resulting in a conversion of 989G to 9891 in the BRI1 kinase domain. An in vitro assay of kinase activity showed that bril-301 has no detectable autophosphorylation activity or phosphorylation activity towards the BRI1 substrates TTL and BAK1. Furthermore, our results suggest that bril-301, even with extremely impaired kinase activity, still retains partial function in regulating plant growth and development, which raises the question of whether BRI1 kinase activity is essential for BR-mediated growth and development in higher plants. 展开更多
关键词 BRASSINOSTEROID bril kinase activity Arabidopsis thaliana
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Analysis of the phytochemical contents and antioxidant activities of crude extracts from Tulbaghia species 被引量:2
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作者 Samkeliso Takaidza Fanyana Mtunzi Michael Pillay 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2018年第2期272-279,共8页
OBJECTIVE: To assess the phytochemical contents and antioxidant activities of crude extracts from selected Tulbaghia species.METHODS: Standard methods were used for preliminary phytochemical analysis. The total phenol... OBJECTIVE: To assess the phytochemical contents and antioxidant activities of crude extracts from selected Tulbaghia species.METHODS: Standard methods were used for preliminary phytochemical analysis. The total phenolic acid contents of the plant extracts were determined using the Folin-Ciocalteu method, and the total flavonoid contents were determined using the aluminum chloride colorimetric method. 1,1-Diphenyl-2-picrylhydrazyl and 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) assays were used to evaluate the antioxidant activities.RESULTS: Phytochemical screening showed flavonoids, glycosides, tannins, terpenoids, saponins,and steroids were present in the Tulbaghia species.The total phenolic acid and flavonoid contents varied in the different plant extracts, ranging from4.50 to 11.10 mg of gallic acid equivalents per gram of fresh material and 3.04 to 9.65 mg of quercetin equivalents per gram, respectively. The IC50 values determined for Tulbaghia alliacea and Tulbaghia violacea based on 1,1-diphenyl-2-picrylhydrazyl(0.06 and 0.08 mg/m L, respectively) and 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)(0.06 and 0.03 mg/m L, respectively) were low and showed they had potential antioxidant activities.CONCLUSION: Our results suggest that individual compounds from Tulbaghia species should be isolated for analysis of their antioxidant activity because some compounds may work best when pure. 展开更多
关键词 Tulbaghia PHYTOCHEMICALS Antioxi-dants PHENOLS
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