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椎体强化治疗骨质疏松椎体压缩骨折 被引量:2
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作者 王强 《中国组织工程研究》 CAS 北大核心 2015年第53期8661-8661,共1页
随着国内社会老龄化的加重,骨质疏松症患者逐年增多。椎体压缩性骨折是骨质疏松患者最常见的并发症之一,其总发病率1.2%,女性发病率1.5%。在椎体压缩性骨折的患者中1,3的患者存在顽固性疼痛,该病引起的疼痛,脊柱畸形可以使患... 随着国内社会老龄化的加重,骨质疏松症患者逐年增多。椎体压缩性骨折是骨质疏松患者最常见的并发症之一,其总发病率1.2%,女性发病率1.5%。在椎体压缩性骨折的患者中1,3的患者存在顽固性疼痛,该病引起的疼痛,脊柱畸形可以使患者的肺活量下降,食欲减退,睡眠影响,活动量减少,从而导致骨量进一步丢失,骨量的丢失又会造成椎体强度进一步下降。 展开更多
关键词 压缩骨折 骨质疏松 椎体强 化治疗
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Changes in Global DNA Methylation Intensity and DNMT1 Transcription During the Aging Process of Scallop Chlamys farreri
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作者 LIAN Shanshan HE Yan +5 位作者 LI Xue ZHAO Bosong HOU Rui HU Xiaoli ZHANG Lingling BAO Zhenmin 《Journal of Ocean University of China》 SCIE CAS 2015年第4期685-690,共6页
DNA methylation is an important epigenetic regulatory mechanism that influences genomic stability, gene activation, X-chromosome inactivation and other factors. A change in DNA methylation is usually associated with a... DNA methylation is an important epigenetic regulatory mechanism that influences genomic stability, gene activation, X-chromosome inactivation and other factors. A change in DNA methylation is usually associated with aging and cellular senescence. DNA methyltransferase 1(DNMT1) is the most abundant DNA methyltransferase, and it plays an important role in maintaining the established methylation pattern during DNA replication in vertebrates. Although the effect of aging on DNA methylation has been well studied in vertebrates, little research has been conducted in invertebrates, especially in marine bivalves. In this study, we examined global DNA methylation levels in four groups of adult Zhikong scallop Chlamys farreri at different ages. The results showed that both the age and tissue type had a strong effect on the DNA methylation. In addition, a significant decrease in DNA methylation with aging(1–4 years) can be detected in mantle, kidney and hepatopancreas. We further measured the change in DNMT1 transcript abundance using quantitative reverse transcription PCR(q RT-PCR), which revealed that DNMT1 transcription significantly decreased with aging in mantle and hepatopancreas and strongly correlated with DNA methylation(R = 0.72). Our data provided greater insight into the aging-related decline of DNA methylation, which could aid in gaining a better understanding of the relationship between DNA methylation and the aging process in bivalve mollusks. 展开更多
关键词 AGING DNA methylation DNMT1 transcription Chlamysfarreri
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