为解决混凝土预制构件生产中存在的模具在模台上组合分配问题,提出一种BL(Bottom-Left)定位算法与改进狼群算法(Improved Wolf Pack Algorithm,IWPA)结合的方法。改进狼群算法用于优化构件的上线序,根据上线序依次将每个构件所使用的模...为解决混凝土预制构件生产中存在的模具在模台上组合分配问题,提出一种BL(Bottom-Left)定位算法与改进狼群算法(Improved Wolf Pack Algorithm,IWPA)结合的方法。改进狼群算法用于优化构件的上线序,根据上线序依次将每个构件所使用的模具分配到模台上,采用BL定位算法确定模具在模台上摆放方向和位置,通过引入莱维飞行思想改进WPA的游猎行为和采用基于汉明距离的狼群动态更新机制来改进狼群算法,丰富狼群多样性,增强WPA在解空间的搜索能力,最后通过实例测试,验证了该方法对于解决该问题的有效性。展开更多
Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as bioch...Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.展开更多
For the accurate prediction of equilibrium distribution ratios of rare earth metals during solvent extraction under non-ideal conditions, the extraction equilibria of yttrium （Ⅲ） and europium （Ⅲ） from the hydroc...For the accurate prediction of equilibrium distribution ratios of rare earth metals during solvent extraction under non-ideal conditions, the extraction equilibria of yttrium （Ⅲ） and europium （Ⅲ） from the hydrochloric acid solutions with P507 in Shellsol D70 were studied. A chemically-based model was established and the extraction equilibrium constants were determined by the nonlinear least squares method. The proposed model involves the cation exchange reaction and the solvation extraction in the low and high acidity regions, respectively. In the model, the nonideality of the aqueous phase and was corrected by considering the complexation of the metals with Cl- and by replacing with its effective concentration, respectively. This model was verified by fair agreement between the calculated metal distribution ratios and those experimentally obtained in the single metal systems. The feed concentrations for the systems are in wide ranges of the metal （up to 0.1 mol/L）, hydrochloric acid （0.07-3.00 mol/L） and the extractant （0.25-1.00 mol/L）. The model enables the engineering prediction of the equilibrium distribution ratios with good accuracy in a binary metal system.展开更多
文摘为解决混凝土预制构件生产中存在的模具在模台上组合分配问题,提出一种BL(Bottom-Left)定位算法与改进狼群算法(Improved Wolf Pack Algorithm,IWPA)结合的方法。改进狼群算法用于优化构件的上线序,根据上线序依次将每个构件所使用的模具分配到模台上,采用BL定位算法确定模具在模台上摆放方向和位置,通过引入莱维飞行思想改进WPA的游猎行为和采用基于汉明距离的狼群动态更新机制来改进狼群算法,丰富狼群多样性,增强WPA在解空间的搜索能力,最后通过实例测试,验证了该方法对于解决该问题的有效性。
文摘Aptamers are a type of single-chain oligonucleotide that can combine with a specific target.Due to their simple preparation,easy modification,stable structure and reusability,aptamers have been widely applied as biochemical sensors for medicine,food safety and environmental monitoring.However,there is little research on aptamer-target binding mechanisms,which limits their application and development.Computational simulation has gained much attention for revealing aptamer-target binding mechanisms at the atomic level.This work summarizes the main simulation methods used in the mechanistic analysis of aptamer-target complexes,the characteristics of binding between aptamers and different targets(metal ions,small organic molecules,biomacromolecules,cells,bacteria and viruses),the types of aptamer-target interactions and the factors influencing their strength.It provides a reference for further use of simulations in understanding aptamer-target binding mechanisms.
基金Project(P02426)supported by the Japan Society for the Promotion of Science for Postdoctoral Fellowships for Foreign Researchers
文摘For the accurate prediction of equilibrium distribution ratios of rare earth metals during solvent extraction under non-ideal conditions, the extraction equilibria of yttrium （Ⅲ） and europium （Ⅲ） from the hydrochloric acid solutions with P507 in Shellsol D70 were studied. A chemically-based model was established and the extraction equilibrium constants were determined by the nonlinear least squares method. The proposed model involves the cation exchange reaction and the solvation extraction in the low and high acidity regions, respectively. In the model, the nonideality of the aqueous phase and was corrected by considering the complexation of the metals with Cl- and by replacing with its effective concentration, respectively. This model was verified by fair agreement between the calculated metal distribution ratios and those experimentally obtained in the single metal systems. The feed concentrations for the systems are in wide ranges of the metal （up to 0.1 mol/L）, hydrochloric acid （0.07-3.00 mol/L） and the extractant （0.25-1.00 mol/L）. The model enables the engineering prediction of the equilibrium distribution ratios with good accuracy in a binary metal system.
