To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders ...To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders of cefoperazone sodium/ sulbactam sodium were directly analyzed by non-destructive NIR reflectance spectroscopy using the spectrometer EQUINOX55. Two quantitative methods via integrating sphere （IS） and fiberoptic probe （FOP） models were explored from 6 batches of commercial samples and 42 batches of laboratory samples at a content ranging from 30% to 70% for cefoperazone and 60% to 20% for sulbactam. The root mean square errors of cross validation （RMSECV） and the root mean square errors of prediction （RMSEP） of IS were 1.79% and 2.85%, respectively, for cefoperazone sodium, and were 1.86% and 3.08%, respectively, for sulbactam sodium; and those of FOP were 2.93% and 2.92%, respectively, for cefoperazone sodium, and were 2.23% and 3.01%, respectively, for sulbactam sodium. Based on the ICH guidelines and Ref. 12, the quantitative models were then evaluated in terms of specificity, linearity, accuracy, precision, robustness and model transferability. The non-destructive quantitative NIR methods used in this study are applicable for rapid analysis of injectable powdered drugs from different manufacturers.展开更多
Marine ecosystem dynamic models(MEDMs) are important tools for the simulation and prediction of marine ecosystems. This article summarizes the methods and strategies used for the improvement and assessment of MEDM ski...Marine ecosystem dynamic models(MEDMs) are important tools for the simulation and prediction of marine ecosystems. This article summarizes the methods and strategies used for the improvement and assessment of MEDM skill, and it attempts to establish a technical framework to inspire further ideas concerning MEDM skill improvement. The skill of MEDMs can be improved by parameter optimization(PO), which is an important step in model calibration. An effi cient approach to solve the problem of PO constrained by MEDMs is the global treatment of both sensitivity analysis and PO. Model validation is an essential step following PO, which validates the effi ciency of model calibration by analyzing and estimating the goodness-of-fi t of the optimized model. Additionally, by focusing on the degree of impact of various factors on model skill, model uncertainty analysis can supply model users with a quantitative assessment of model confi dence. Research on MEDMs is ongoing; however, improvement in model skill still lacks global treatments and its assessment is not integrated. Thus, the predictive performance of MEDMs is not strong and model uncertainties lack quantitative descriptions, limiting their application. Therefore, a large number of case studies concerning model skill should be performed to promote the development of a scientifi c and normative technical framework for the improvement of MEDM skill.展开更多
Discriminant space defining area classes is an important conceptual construct for uncertainty characterization in area-class maps.Discriminant models were promoted as they can enhance consistency in area-class mapping...Discriminant space defining area classes is an important conceptual construct for uncertainty characterization in area-class maps.Discriminant models were promoted as they can enhance consistency in area-class mapping and replicability in error modeling.As area classes are rarely completely separable in empirically realized discriminant space,where class inseparabil-ity becomes more complicated for change categorization,we seek to quantify uncertainty in area classes(and change classes)due to measurement errors and semantic discrepancy separately and hence assess their relative margins objectively.Experiments using real datasets were carried out,and a Bayesian method was used to obtain change maps.We found that there are large differences be-tween uncertainty statistics referring to data classes and information classes.Therefore,uncertainty characterization in change categorization should be based on discriminant modeling of measurement errors and semantic mismatch analysis,enabling quanti-fication of uncertainty due to partially random measurement errors,and systematic categorical discrepancies,respectively.展开更多
基金National Key Technologies R&D Program Foundation of China (Grant No. 2006BAK04A11)
文摘To develop near-infrared （NIR） reflectance spectroscopic methods for the quantitative analysis of cefoperazone sodium/ sulbactam sodium from different manufacturers for injection powder medicaments. Various powders of cefoperazone sodium/ sulbactam sodium were directly analyzed by non-destructive NIR reflectance spectroscopy using the spectrometer EQUINOX55. Two quantitative methods via integrating sphere （IS） and fiberoptic probe （FOP） models were explored from 6 batches of commercial samples and 42 batches of laboratory samples at a content ranging from 30% to 70% for cefoperazone and 60% to 20% for sulbactam. The root mean square errors of cross validation （RMSECV） and the root mean square errors of prediction （RMSEP） of IS were 1.79% and 2.85%, respectively, for cefoperazone sodium, and were 1.86% and 3.08%, respectively, for sulbactam sodium; and those of FOP were 2.93% and 2.92%, respectively, for cefoperazone sodium, and were 2.23% and 3.01%, respectively, for sulbactam sodium. Based on the ICH guidelines and Ref. 12, the quantitative models were then evaluated in terms of specificity, linearity, accuracy, precision, robustness and model transferability. The non-destructive quantitative NIR methods used in this study are applicable for rapid analysis of injectable powdered drugs from different manufacturers.
基金Supported by the National Natural Science Foundation of China(Nos.41206111,41206112)
文摘Marine ecosystem dynamic models(MEDMs) are important tools for the simulation and prediction of marine ecosystems. This article summarizes the methods and strategies used for the improvement and assessment of MEDM skill, and it attempts to establish a technical framework to inspire further ideas concerning MEDM skill improvement. The skill of MEDMs can be improved by parameter optimization(PO), which is an important step in model calibration. An effi cient approach to solve the problem of PO constrained by MEDMs is the global treatment of both sensitivity analysis and PO. Model validation is an essential step following PO, which validates the effi ciency of model calibration by analyzing and estimating the goodness-of-fi t of the optimized model. Additionally, by focusing on the degree of impact of various factors on model skill, model uncertainty analysis can supply model users with a quantitative assessment of model confi dence. Research on MEDMs is ongoing; however, improvement in model skill still lacks global treatments and its assessment is not integrated. Thus, the predictive performance of MEDMs is not strong and model uncertainties lack quantitative descriptions, limiting their application. Therefore, a large number of case studies concerning model skill should be performed to promote the development of a scientifi c and normative technical framework for the improvement of MEDM skill.
基金Supported by the National Natural Science Foundation of China (No.41171346,No. 41071286)the Fundamental Research Funds for the Central Universities (No. 20102130103000005)the National 973 Program of China (No. 2007CB714402‐5)
文摘Discriminant space defining area classes is an important conceptual construct for uncertainty characterization in area-class maps.Discriminant models were promoted as they can enhance consistency in area-class mapping and replicability in error modeling.As area classes are rarely completely separable in empirically realized discriminant space,where class inseparabil-ity becomes more complicated for change categorization,we seek to quantify uncertainty in area classes(and change classes)due to measurement errors and semantic discrepancy separately and hence assess their relative margins objectively.Experiments using real datasets were carried out,and a Bayesian method was used to obtain change maps.We found that there are large differences be-tween uncertainty statistics referring to data classes and information classes.Therefore,uncertainty characterization in change categorization should be based on discriminant modeling of measurement errors and semantic mismatch analysis,enabling quanti-fication of uncertainty due to partially random measurement errors,and systematic categorical discrepancies,respectively.
