An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alp...An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alpha and ribavirin is only effective in a subset of patients, the development of new HCV antivirals is a healthcare imperative. This review discusses the experimental models available for HCV antiviral drug research, recent advances in HCV antiviral drug development, as well as active research being pursued to facilitate development of new HCV-specific therapeutics.展开更多
This research proposes a modified two-dimensional Peng-Robinson equation model to predict adsorption isotherm in adsorbate-adsorbent systems. The parameters of the proposed model are calculated by using the optimizati...This research proposes a modified two-dimensional Peng-Robinson equation model to predict adsorption isotherm in adsorbate-adsorbent systems. The parameters of the proposed model are calculated by using the optimization of experimental data for the different single gas adsorption systems at various temperatures. The experimental adsorption equilibrium data of adsorbate-adsorbent systems was compared with the calculated results in our proposed model and the two-dimensional Hill-deBoer equation model. The proposed model as indicated in the results shows a better prediction of the experimental results compared with two others.展开更多
In order to overcome defects of the classical hidden Markov model (HMM), Markov family model (MFM), a new statistical model was proposed. Markov family model was applied to speech recognition and natural language proc...In order to overcome defects of the classical hidden Markov model (HMM), Markov family model (MFM), a new statistical model was proposed. Markov family model was applied to speech recognition and natural language processing. The speaker independently continuous speech recognition experiments and the part-of-speech tagging experiments show that Markov family model has higher performance than hidden Markov model. The precision is enhanced from 94.642% to 96.214% in the part-of-speech tagging experiments, and the work rate is reduced by 11.9% in the speech recognition experiments with respect to HMM baseline system.展开更多
This paper presents a new theoretical model to determine the optimal axial preload of a spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stif...This paper presents a new theoretical model to determine the optimal axial preload of a spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stiffness was treated as the sum of the spindle modal stiffness and the framework elastic stiffness, based on a novel concept that magnitude of preloads can be controlled by measuring the resonant frequency of a spindle system. By employing an example of a certain type of aircraft simulating rotary table, the modal stiffness was measured on the Agilent 35670A Dynamic Signal Analyzer by experimental modal analysis. The equivalent elastic stiffness was simulated by both finite element analysis in ANSYS? and a curve fitting in MATLAB?. Results showed that the static preloading stiffness of the spindle was 7.2125×107 N/m, and that the optimal preloading force was 120.0848 N. Practical application proved the feasibility of our method.展开更多
Physical testing of large-scale ship models at sea is a new experimental method.It is a cheap and reliable way to research the environment adaptability of a ship in complex and extreme wave conditions.It is necessary ...Physical testing of large-scale ship models at sea is a new experimental method.It is a cheap and reliable way to research the environment adaptability of a ship in complex and extreme wave conditions.It is necessary to have a stable experimental system for the test.Since the experimental area is large, a remote control system and a telemetry system are essential, and were designed by the authors.An experiment was conducted on the Songhuajiang River to test the systems.The relationship between the model's speed and its electromotor's revolutions was also measured during the model test.The results showed that the two systems make it possible to carry out large-scale model tests at sea.展开更多
Solid–liquid phase equilibrium data for binary(L-arabinose–water) and(D-xylose–water) systems at temperatures from(269.85–298.05) K and ternary(L-arabinose–D-xylose–water) system at temperatures of 273.85 K,278....Solid–liquid phase equilibrium data for binary(L-arabinose–water) and(D-xylose–water) systems at temperatures from(269.85–298.05) K and ternary(L-arabinose–D-xylose–water) system at temperatures of 273.85 K,278.85 K and 284.45 K were measured at atmospheric pressure.The ternary phase diagrams of the systems were constructed on the base of the measured solubility.Two pure solid phases were formed at given temperatures,including pure L-arabinose and pure D-xylose,which were con firmed and determined by the method of Schreinemakers' wet residue.At the same temperature,the crystallization region of L-arabinose was larger than D-xylose's.The acquired solubility data were then correlated using the NRTL model,Wilson model and Xu model.The calculated solubility with the three models agreed well with the experimental values.展开更多
The characteristics of three GPS kinematic data processing models, Least Squares (LS), Kalman filtering and filtering are discussed and their advantages and disadvantages are compared. With observational data and p...The characteristics of three GPS kinematic data processing models, Least Squares (LS), Kalman filtering and filtering are discussed and their advantages and disadvantages are compared. With observational data and pertinent data processing software, the applicable condition, context and effect of the three models are experimented. Results show that when the mobile platform is in uniform motion, the accuracy of the three models are almost equal; when the mobile platform is in stochastic acceleration, the accuracy of H∞ filtering model is superior to that of LS, while that of Kalman filtering is the worst.展开更多
Magnetorheological (MR) dampers have been proposed to control the vibration of offshore platforms in this paper. The semi-active control strategy based on fuzzy control algorithm was adopted to determine the optimal...Magnetorheological (MR) dampers have been proposed to control the vibration of offshore platforms in this paper. The semi-active control strategy based on fuzzy control algorithm was adopted to determine the optimal output control force based on the responses of jacket platforms. A typical jacket platform in Mexico Gulf was selected as the numerical example to investigate the effectiveness of the proposed control method. Furthermore, a model experiment was performed to validate the results of the numerical simulation. The experimental model of the jacket platform was designed based on dynamical similarity criterion by the scale of 1:50. Both of the numerical and experimental results show that the semi-active control system with the MR damper can reduce vibrations of jacket platforms effectively and at the same time the control effect is stable.展开更多
Extreme coastal events require careful prediction of wave forces. Recent tsunamis have resulted in extensive damage of coastal structures. Such scenarios are the result of the action of long waves on structures. In th...Extreme coastal events require careful prediction of wave forces. Recent tsunamis have resulted in extensive damage of coastal structures. Such scenarios are the result of the action of long waves on structures. In this paper, the efficiency of vegetation as a buffer system in attenuating the incident ocean waves was studied through a well controlled experimental program. The study focused on the measurement of forces resulting from cnoidal waves on a model building mounted over a slope in the presence and absence of vegetation. The vegetative parameters, along with the width of the green belt, its position from the reference line, the diameter of the individual stems as well as the spacing between them, and their rigidity are varied so as to obtain a holistic view of the wave-vegetation interaction problem. The effect of vegetation on variations of dimensional forces with a Keulegan-Carpenter number (KC) was discussed in this paper. It has been shown that when vegetal patches are present in front of structure, the forces could be limited to within F*≤I, by a percentile of 92%, 90%, 55%, and 96%, respectively for gap ratios of 0.0, 0.5, 1.0, and 1.5. The force is at its maximum for the gap ratio of 1.0 and beyond which the forces start to diminish.展开更多
Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried ...Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase.展开更多
In order to utilize the spontaneous accumulation of heat (SAH) reasonably and obtain the high quality sinter with low energy consumption, a lower fuel consumption modeling based on raw materials of a certain steel wor...In order to utilize the spontaneous accumulation of heat (SAH) reasonably and obtain the high quality sinter with low energy consumption, a lower fuel consumption modeling based on raw materials of a certain steel works was built. An air-flow segregation feeding (ASF) experimental equipment was designed to simulate strand feeding process and calculate the lower fuel consumption quantity. Compared with baseline test, the ASF experimental equipment was adopted. The results of sinter pot tests show that the solid fuel consumption is lower than that in baseline test, which is decreased by 5.8%. Meanwhile, other sinter indexes, such as pan yeild, tumbler strength and strand productivity are improved. The mineralogical examination indicates that the mineral compositions and micostructures are improved in sinter.展开更多
DAR (diffusion absorption refrigeration) cycle is driven by heat and has no moving parts. It is based on refrigerant and absorbent as the working fluid together with hydrogen as an auxiliary inert gas. To circulate ...DAR (diffusion absorption refrigeration) cycle is driven by heat and has no moving parts. It is based on refrigerant and absorbent as the working fluid together with hydrogen as an auxiliary inert gas. To circulate the working fluid without a mechanical pump, the diffusion absorption cycle relies on a bubble pump. Experimental system was designed and operated. Its aim was to investigate the performance of a bubble pump operating with three lifting tubes. The experimental results of the system were compared to existing models. The comparison showed that there was a bad agreement between the experimental and the theoretical results.展开更多
The relationship between crop richness and predator-prey interactions as they relate to pest-natural enemy systems is a very important topic in ecology and greatly affects biological control services.The effects of cr...The relationship between crop richness and predator-prey interactions as they relate to pest-natural enemy systems is a very important topic in ecology and greatly affects biological control services.The effects of crop arrangement on predator-prey interactions have received much attention as the basis for pest population management.To explore the internal mechanisms and factors driving the relationship between crop richness and pest population management,we designed an experimental model system of a microlandscape that included 50 plots and five treatments.Each treatment had 10 repetitions in each year from 2007 to 2010.The results showed that the biomass of pests and their natural enemies increased with increasing crop biomass and decreased with decreasing crop biomass;however,the effects of plant biomass on the pest and natural enemy biomass were not significant.The relationship between adjacent trophic levels was significant(such as pests and their natural enemies or crops and pests),whereas non-adjacent trophic levels(crops and natural enemies) did not significantly interact with each other.The ratio of natural enemy/pest biomass was the highest in the areas of four crop species that had the best biological control service.Having either low or high crop species richness did not enhance the pest population management service and lead to loss of biological control.Although the resource concentration hypothesis was not well supported by our results,high crop species richness could suppress the pest population,indicating that crop species richness could enhance biological control services.These results could be applied in habitat management aimed at biological control,provide the theoretical basis for agricultural landscape design,and also suggest new methods for integrated pest management.展开更多
Surface vortex behavior in front of the tunnel intake was investigated in this paper.The critical submergence of vortex was discussed based on the concept of 'critical spherical sink surface'(CSSS).The vortex ...Surface vortex behavior in front of the tunnel intake was investigated in this paper.The critical submergence of vortex was discussed based on the concept of 'critical spherical sink surface'(CSSS).The vortex formation and evolution at the tunnel intake were analyzed based on the theory of CSSS considering the effect of circulation.A theory was proposed to explain the surface vortex.The theoretical development was verified by the physical model experiments of Xiluodu hydropower station.The radial velocity and vortex circulation were considered as the main factors that influence the formation and evolution of surface vortex.Finally,an anti-vortex intake configuration was proposed to weaken the air-core vortex in front of the tunnel intakes of the hydraulic structures.展开更多
基金supported by National Institutes of Health grants AI070827 and CA33266American Cancer Society grant RSG-09-076-01 and the UIC Walter Payton Center GUILD
文摘An estimated 130 million people worldwide are chronically infected with hepatitis C virus (HCV) making it a leading cause of liver disease worldwide. Because the currently available therapy of pegylated interferon-alpha and ribavirin is only effective in a subset of patients, the development of new HCV antivirals is a healthcare imperative. This review discusses the experimental models available for HCV antiviral drug research, recent advances in HCV antiviral drug development, as well as active research being pursued to facilitate development of new HCV-specific therapeutics.
文摘This research proposes a modified two-dimensional Peng-Robinson equation model to predict adsorption isotherm in adsorbate-adsorbent systems. The parameters of the proposed model are calculated by using the optimization of experimental data for the different single gas adsorption systems at various temperatures. The experimental adsorption equilibrium data of adsorbate-adsorbent systems was compared with the calculated results in our proposed model and the two-dimensional Hill-deBoer equation model. The proposed model as indicated in the results shows a better prediction of the experimental results compared with two others.
基金Project(60763001)supported by the National Natural Science Foundation of ChinaProjects(2009GZS0027,2010GZS0072)supported by the Natural Science Foundation of Jiangxi Province,China
文摘In order to overcome defects of the classical hidden Markov model (HMM), Markov family model (MFM), a new statistical model was proposed. Markov family model was applied to speech recognition and natural language processing. The speaker independently continuous speech recognition experiments and the part-of-speech tagging experiments show that Markov family model has higher performance than hidden Markov model. The precision is enhanced from 94.642% to 96.214% in the part-of-speech tagging experiments, and the work rate is reduced by 11.9% in the speech recognition experiments with respect to HMM baseline system.
文摘This paper presents a new theoretical model to determine the optimal axial preload of a spindle system, for challenging the traditional method which relies heavily on experience of engineers. The axial preloading stiffness was treated as the sum of the spindle modal stiffness and the framework elastic stiffness, based on a novel concept that magnitude of preloads can be controlled by measuring the resonant frequency of a spindle system. By employing an example of a certain type of aircraft simulating rotary table, the modal stiffness was measured on the Agilent 35670A Dynamic Signal Analyzer by experimental modal analysis. The equivalent elastic stiffness was simulated by both finite element analysis in ANSYS? and a curve fitting in MATLAB?. Results showed that the static preloading stiffness of the spindle was 7.2125×107 N/m, and that the optimal preloading force was 120.0848 N. Practical application proved the feasibility of our method.
基金Supported by the National Defense Foundation under Grant No.51414030204CB0109
文摘Physical testing of large-scale ship models at sea is a new experimental method.It is a cheap and reliable way to research the environment adaptability of a ship in complex and extreme wave conditions.It is necessary to have a stable experimental system for the test.Since the experimental area is large, a remote control system and a telemetry system are essential, and were designed by the authors.An experiment was conducted on the Songhuajiang River to test the systems.The relationship between the model's speed and its electromotor's revolutions was also measured during the model test.The results showed that the two systems make it possible to carry out large-scale model tests at sea.
基金Supported by the National Natural Science Foundation of China(21376231)
文摘Solid–liquid phase equilibrium data for binary(L-arabinose–water) and(D-xylose–water) systems at temperatures from(269.85–298.05) K and ternary(L-arabinose–D-xylose–water) system at temperatures of 273.85 K,278.85 K and 284.45 K were measured at atmospheric pressure.The ternary phase diagrams of the systems were constructed on the base of the measured solubility.Two pure solid phases were formed at given temperatures,including pure L-arabinose and pure D-xylose,which were con firmed and determined by the method of Schreinemakers' wet residue.At the same temperature,the crystallization region of L-arabinose was larger than D-xylose's.The acquired solubility data were then correlated using the NRTL model,Wilson model and Xu model.The calculated solubility with the three models agreed well with the experimental values.
基金the National Natural Foundation of China (No.40574002)the Natural Foundation of Guang Xi Zhuang Autonomous Re-gion (No. 0728097)
文摘The characteristics of three GPS kinematic data processing models, Least Squares (LS), Kalman filtering and filtering are discussed and their advantages and disadvantages are compared. With observational data and pertinent data processing software, the applicable condition, context and effect of the three models are experimented. Results show that when the mobile platform is in uniform motion, the accuracy of the three models are almost equal; when the mobile platform is in stochastic acceleration, the accuracy of H∞ filtering model is superior to that of LS, while that of Kalman filtering is the worst.
基金Supported by the National Natural Science Foundation of China (NSFC-5060900).
文摘Magnetorheological (MR) dampers have been proposed to control the vibration of offshore platforms in this paper. The semi-active control strategy based on fuzzy control algorithm was adopted to determine the optimal output control force based on the responses of jacket platforms. A typical jacket platform in Mexico Gulf was selected as the numerical example to investigate the effectiveness of the proposed control method. Furthermore, a model experiment was performed to validate the results of the numerical simulation. The experimental model of the jacket platform was designed based on dynamical similarity criterion by the scale of 1:50. Both of the numerical and experimental results show that the semi-active control system with the MR damper can reduce vibrations of jacket platforms effectively and at the same time the control effect is stable.
文摘Extreme coastal events require careful prediction of wave forces. Recent tsunamis have resulted in extensive damage of coastal structures. Such scenarios are the result of the action of long waves on structures. In this paper, the efficiency of vegetation as a buffer system in attenuating the incident ocean waves was studied through a well controlled experimental program. The study focused on the measurement of forces resulting from cnoidal waves on a model building mounted over a slope in the presence and absence of vegetation. The vegetative parameters, along with the width of the green belt, its position from the reference line, the diameter of the individual stems as well as the spacing between them, and their rigidity are varied so as to obtain a holistic view of the wave-vegetation interaction problem. The effect of vegetation on variations of dimensional forces with a Keulegan-Carpenter number (KC) was discussed in this paper. It has been shown that when vegetal patches are present in front of structure, the forces could be limited to within F*≤I, by a percentile of 92%, 90%, 55%, and 96%, respectively for gap ratios of 0.0, 0.5, 1.0, and 1.5. The force is at its maximum for the gap ratio of 1.0 and beyond which the forces start to diminish.
基金Supported by the National Natural Science Foundation of China(20976103)
文摘Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase.
基金Project(NECT-04-0748) supported by New Century Excellent Talents Program of China
文摘In order to utilize the spontaneous accumulation of heat (SAH) reasonably and obtain the high quality sinter with low energy consumption, a lower fuel consumption modeling based on raw materials of a certain steel works was built. An air-flow segregation feeding (ASF) experimental equipment was designed to simulate strand feeding process and calculate the lower fuel consumption quantity. Compared with baseline test, the ASF experimental equipment was adopted. The results of sinter pot tests show that the solid fuel consumption is lower than that in baseline test, which is decreased by 5.8%. Meanwhile, other sinter indexes, such as pan yeild, tumbler strength and strand productivity are improved. The mineralogical examination indicates that the mineral compositions and micostructures are improved in sinter.
文摘DAR (diffusion absorption refrigeration) cycle is driven by heat and has no moving parts. It is based on refrigerant and absorbent as the working fluid together with hydrogen as an auxiliary inert gas. To circulate the working fluid without a mechanical pump, the diffusion absorption cycle relies on a bubble pump. Experimental system was designed and operated. Its aim was to investigate the performance of a bubble pump operating with three lifting tubes. The experimental results of the system were compared to existing models. The comparison showed that there was a bad agreement between the experimental and the theoretical results.
基金supported by the National Natural Science Foundation of China (31030012)National Key Technology Research & Development Program (2012BAD19B05)Special Fund for Agro-scientific Research in the Public Interest (201103012)
文摘The relationship between crop richness and predator-prey interactions as they relate to pest-natural enemy systems is a very important topic in ecology and greatly affects biological control services.The effects of crop arrangement on predator-prey interactions have received much attention as the basis for pest population management.To explore the internal mechanisms and factors driving the relationship between crop richness and pest population management,we designed an experimental model system of a microlandscape that included 50 plots and five treatments.Each treatment had 10 repetitions in each year from 2007 to 2010.The results showed that the biomass of pests and their natural enemies increased with increasing crop biomass and decreased with decreasing crop biomass;however,the effects of plant biomass on the pest and natural enemy biomass were not significant.The relationship between adjacent trophic levels was significant(such as pests and their natural enemies or crops and pests),whereas non-adjacent trophic levels(crops and natural enemies) did not significantly interact with each other.The ratio of natural enemy/pest biomass was the highest in the areas of four crop species that had the best biological control service.Having either low or high crop species richness did not enhance the pest population management service and lead to loss of biological control.Although the resource concentration hypothesis was not well supported by our results,high crop species richness could suppress the pest population,indicating that crop species richness could enhance biological control services.These results could be applied in habitat management aimed at biological control,provide the theoretical basis for agricultural landscape design,and also suggest new methods for integrated pest management.
基金supported by Tsinghua University Initiative Scientific Research Program (Grant No. 2009THZ07060)the State Key Laboratory of Hydroscience and Engineering of Tsinghua University (Grant No. 2010-TC-2,2009-TC-2)
文摘Surface vortex behavior in front of the tunnel intake was investigated in this paper.The critical submergence of vortex was discussed based on the concept of 'critical spherical sink surface'(CSSS).The vortex formation and evolution at the tunnel intake were analyzed based on the theory of CSSS considering the effect of circulation.A theory was proposed to explain the surface vortex.The theoretical development was verified by the physical model experiments of Xiluodu hydropower station.The radial velocity and vortex circulation were considered as the main factors that influence the formation and evolution of surface vortex.Finally,an anti-vortex intake configuration was proposed to weaken the air-core vortex in front of the tunnel intakes of the hydraulic structures.