An object oriented data modelling in computer aided design (CAD) databases is focused. Starting with the discussion of data modelling requirements for CAD applications, appropriate data modelling features are introdu...An object oriented data modelling in computer aided design (CAD) databases is focused. Starting with the discussion of data modelling requirements for CAD applications, appropriate data modelling features are introduced herewith. A feasible approach to select the “best” data model for an application is to analyze the data which has to be stored in the database. A data model is appropriate for modelling a given task if the information of the application environment can be easily mapped to the data model. Thus, the involved data are analyzed and then object oriented data model appropriate for CAD applications are derived. Based on the reviewed object oriented techniques applied in CAD, object oriented data modelling in CAD is addressed in details. At last 3D geometrical data models and implementation of their data model using the object oriented method are presented.展开更多
Discussing the matter of organizational data management implies, almost automatically, the concept of data warehousing as one of the most important parts of decision support system （DSS）, as it supports the integrat...Discussing the matter of organizational data management implies, almost automatically, the concept of data warehousing as one of the most important parts of decision support system （DSS）, as it supports the integration of information management by aggregating all data formats and provisioning external systems with consistent data content and flows, together with the metadata concept, as one of the easiest ways of integration for software and database systems. Since organizational data management uses the metadata channel for creating a bi-directional flow, when correctly managed, metadata can save both time and resources for organizations. This paperI will focus on providing theoretical aspects of the two concepts, together with a short brief over a proposed model of design for an organizational management tool.展开更多
Natural products（NPs） have long been recognized as a valuable resource for drug discovery, and bringing NP-related features to virtual libraries is believed to be an effective way to increase the coverage of druggab...Natural products（NPs） have long been recognized as a valuable resource for drug discovery, and bringing NP-related features to virtual libraries is believed to be an effective way to increase the coverage of druggable chemical space. Here, deep learning-based molecule generative model, which is a recent technique in de novo molecule design, was applied to generate virtual libraries with NP-like properties. Results demonstrated that the model was effective in generating molecules that highly resemble NPs. Moreover, the model was also found to be capable of generating NP-like molecules that were also easy to synthesize, significantly increasing the practical value of the compound library.展开更多
文摘An object oriented data modelling in computer aided design (CAD) databases is focused. Starting with the discussion of data modelling requirements for CAD applications, appropriate data modelling features are introduced herewith. A feasible approach to select the “best” data model for an application is to analyze the data which has to be stored in the database. A data model is appropriate for modelling a given task if the information of the application environment can be easily mapped to the data model. Thus, the involved data are analyzed and then object oriented data model appropriate for CAD applications are derived. Based on the reviewed object oriented techniques applied in CAD, object oriented data modelling in CAD is addressed in details. At last 3D geometrical data models and implementation of their data model using the object oriented method are presented.
文摘Discussing the matter of organizational data management implies, almost automatically, the concept of data warehousing as one of the most important parts of decision support system （DSS）, as it supports the integration of information management by aggregating all data formats and provisioning external systems with consistent data content and flows, together with the metadata concept, as one of the easiest ways of integration for software and database systems. Since organizational data management uses the metadata channel for creating a bi-directional flow, when correctly managed, metadata can save both time and resources for organizations. This paperI will focus on providing theoretical aspects of the two concepts, together with a short brief over a proposed model of design for an organizational management tool.
基金The National Natural Science Foundation of China(Grant No.81573273,81673279,21572010 and 21772005)National Major Scientific and Technological Special Project for"Significant New Drugs Development"(Grant No.2018ZX09735001-003)
文摘Natural products（NPs） have long been recognized as a valuable resource for drug discovery, and bringing NP-related features to virtual libraries is believed to be an effective way to increase the coverage of druggable chemical space. Here, deep learning-based molecule generative model, which is a recent technique in de novo molecule design, was applied to generate virtual libraries with NP-like properties. Results demonstrated that the model was effective in generating molecules that highly resemble NPs. Moreover, the model was also found to be capable of generating NP-like molecules that were also easy to synthesize, significantly increasing the practical value of the compound library.
