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基于GC-MS的慢性髓系白血病代谢轮廓分析 被引量:3
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作者 杨冰玉 李晓莉 +4 位作者 姚遥 王畅 陈苏宁 吴小津 吴德沛 《中国实验血液学杂志》 CAS CSCD 北大核心 2017年第6期1585-1591,共7页
目的:应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法对慢性髓系白血病(CML)患者血浆进行代谢轮廓分析,寻找与疾病相关的潜在标志物,并初步探讨其涉及的相关代谢通路。方法:选取2015年2月至2015年4月在苏州大学附属第一医院初次确诊... 目的:应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法对慢性髓系白血病(CML)患者血浆进行代谢轮廓分析,寻找与疾病相关的潜在标志物,并初步探讨其涉及的相关代谢通路。方法:选取2015年2月至2015年4月在苏州大学附属第一医院初次确诊的26例CML患者,及26例同期异基因造血干细胞供者(健康对照),另取26例经过一代酪氨酸激酶抑制剂(TKI)治疗后获得最佳疗效的CML患者(治疗后对照)。应用气相色谱质谱联用技术(GC-MS)方法对三组血浆样本进行代谢物无靶标检测,采集代谢物指纹图谱,结合模式识别分析方法及t检验筛选差异代谢物,通过受试者工作曲线(receiver operating characteristic curve,ROC)分析,评价差异代谢物临床效能,并进行Met PA代谢通路分析。结果:健康人及初诊CML患者血浆代谢表型明显不同。与健康对照组比较,CML组有6个血浆代谢物表现出差异,肉豆蔻酸、甘油丰度均较健康对照组低,而肌醇、半乳糖、乳酸、甘氨酸丰度均较健康对照组高(VIP>1,P<0.05,AUC>0.7),经过TKI药物治疗后获得最佳疗效的CML患者上述差异血浆代谢物均有向正常人水平恢复的趋势。以上CML患者血浆代谢紊乱通路主要与半乳糖代谢、丙酮酸代谢、甘油酯代谢、甘氨酸丝氨酸苏氨酸代谢相关(影响值>0.10)。结论:CML患者血浆中代谢物水平出现显著变化,代谢组学结合模式识别分析方法可能成为CML辅助诊断的新方法。 展开更多
关键词 慢性髓系白血病 代谢组学 气相色谱质谱联用技术 模式识别分析方法
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Temporal-spatial cross-correlation analysis of non-stationary near-surface wind speed time series 被引量:3
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作者 ZENG Ming LI Jing-hai +1 位作者 MENG Qing-hao ZHANG Xiao-nei 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第3期692-698,共7页
Temporal-spatial cross-correlation analysis of non-stationary wind speed time series plays a crucial role in wind field reconstruction as well as in wind pattern recognition.Firstly,the near-surface wind speed time se... Temporal-spatial cross-correlation analysis of non-stationary wind speed time series plays a crucial role in wind field reconstruction as well as in wind pattern recognition.Firstly,the near-surface wind speed time series recorded at different locations are studied using the detrended fluctuation analysis(DFA),and the corresponding scaling exponents are larger than 1.This indicates that all these wind speed time series have non-stationary characteristics.Secondly,concerning this special feature( i.e.,non-stationarity)of wind signals,a cross-correlation analysis method,namely detrended cross-correlation analysis(DCCA) coefficient,is employed to evaluate the temporal-spatial cross-correlations between non-stationary time series of different anemometer pairs.Finally,experiments on ten wind speed data synchronously collected by the ten anemometers with equidistant arrangement illustrate that the method of DCCA cross-correlation coefficient can accurately analyze full-scale temporal-spatial cross-correlation between non-stationary time series and also can easily identify the seasonal component,while three traditional cross-correlation techniques(i.e.,Pearson coefficient,cross-correlation function,and DCCA method) cannot give us these information directly. 展开更多
关键词 temporal-spatial cross-correlation near-surface wind speed time series detrended cross-correlation analysis (DCCA) cross-correlation coefficient Pearson coefficient cross-correlation function
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A NOVEL ALGORITHM FOR VOICE CONVERSION USING CANONICAL CORRELATION ANALYSIS
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作者 Jian Zhihua Yang Zhen 《Journal of Electronics(China)》 2008年第3期358-363,共6页
A novel algorithm for voice conversion is proposed in this paper. The mapping function of spectral vectors of the source and target speakers is calculated by the Canonical Correlation Analysis (CCA) estimation based o... A novel algorithm for voice conversion is proposed in this paper. The mapping function of spectral vectors of the source and target speakers is calculated by the Canonical Correlation Analysis (CCA) estimation based on Gaussian mixture models. Since the spectral envelope feature remains a majority of second order statistical information contained in speech after Linear Prediction Coding (LPC) analysis, the CCA method is more suitable for spectral conversion than Minimum Mean Square Error (MMSE) because CCA explicitly considers the variance of each component of the spectral vectors during conversion procedure. Both objective evaluations and subjective listening tests are conducted. The experimental results demonstrate that the proposed scheme can achieve better per- formance than the previous method which uses MMSE estimation criterion. 展开更多
关键词 Speech processing Voice conversion Canonical Correlation Analysis (CCA)
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