AIM: To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis. METHODS: E2F5 expression was analyzed in 120 primary HCCs and 29 norm...AIM: To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis. METHODS: E2F5 expression was analyzed in 120 primary HCCs and 29 normal liver tissues by immunohistochemistry analysis. E2F5-small interfering RNA was transfected into HepG2, an E2F5-overexpressed HCC cell line. After E2F5 knockdown, cell growth capacity and migrating potential were examined. RESULTS: E2F5 was significantly overexpressed in primary HCCs compared with normal liver tissues (P = 0.008). The E2F5-silenced cells showed significantly reduced proliferation (P = 0.004). On the colony formation and soft agar assays, the number of colonies was significantly reduced in E2F5-silenced cells (P = 0.004 and P = 0.009, respectively). E2F5 knockdown resulted in the accumulation of G0/G1 phase cells and a reduction of S phase cells. The number of migrating/invading cells was also reduced after E2F5 knockdown (P = 0.021). CONCLUSION: To our knowledge, this is the first evidence that E2F5 is commonly overexpressed in primary HCC and that E2F5 knockdown significantly repressed the growth of HCC cells.展开更多
Multimode interference (MMI) devices are widely used in planar lightwave circuit (PLC). The device length can be well reduced with tapered multimode region. Traditional design formula shows large error for MMI devices...Multimode interference (MMI) devices are widely used in planar lightwave circuit (PLC). The device length can be well reduced with tapered multimode region. Traditional design formula shows large error for MMI devices based on weakly- restricted waveguide. Based on the analysis with mode width as a substitution of waveguide width, a design formula with better precision was presented. Comparison with software simulation verified its exactness.展开更多
Climatic factor's effect was studied on the radial growth of teak (Tectona grandis L.F.) by using the stem analysis of 36 trees distributed in 6 plantations in Parakou and Tchaourou districts in northern Benin. The...Climatic factor's effect was studied on the radial growth of teak (Tectona grandis L.F.) by using the stem analysis of 36 trees distributed in 6 plantations in Parakou and Tchaourou districts in northern Benin. The results showed that the plantations of Parakou were in general more productive than those of Tchaourou. The annual average growth was estimated in the first five years at 0.86 cm/year for Parakou and 0.76 cm/year at Tchaourou. The analysis of the radial growth showed that a significant percentage of the variance was allotted to the growth model. It follows that a big part of the ring width was predetermined before the intervention of the other factors, in particular the climatic conditions. The percentage of the variance related to the climatic conditions was thus more reduced for the plantations of Tchaourou than those of Parakou. The radial growth was influenced by the conditions of humidity (evapotranspiration, humidity and rain) of February to May on the one hand and those from August to October on the other hand.展开更多
A simultaneous visualization and measurement experiment was carried out to investigate condensation flow pat- terns and condensing heat transfer characteristics of refrigerant R14 lb in parallel horizontal multi-chann...A simultaneous visualization and measurement experiment was carried out to investigate condensation flow pat- terns and condensing heat transfer characteristics of refrigerant R14 lb in parallel horizontal multi-channels with liquid-vapor separator. The hydraulic diameter of each channel was 1.5 mm and the channel length was 100 ram. The refrigerant vapor flowing in the small channels was cooled by cooling water. The parallel horizontal mul- ti-channels were covered with a transparent silica glass for visualization of flow patterns. Experiments were per- formed at different inlet superheat temperatures (ranging from 3~C to 7~C). Mass velocity was in the range of 82.37 kg mZs1 to 35.56 kg m-2s1. It was found that there were three different flow patterns through the mul- ti-channels with the increase of mass velocity. The flow patterns in each channel pass almost tended to be same and all of them were annular flows.' The efficiency of the liquid-vapor separator with U-type was related to vapor mass velocity and the pressure in the small channels. It was also found that the heat transfer coefficient increased with the increase of the mass velocity while the cooling water mass flow rate increased. It increased to a top point and then decreased. It increased with the increase of superheat in the low superheat temperature region.展开更多
Aerodynamic roughness length is an important physical parameter in atmospheric numerical models and microme- teorological calculations, the accuracy of which can affect numerical model performance and the level of mic...Aerodynamic roughness length is an important physical parameter in atmospheric numerical models and microme- teorological calculations, the accuracy of which can affect numerical model performance and the level of micrometeorological computations. Many factors influence the aerodynamic roughness length, but formulas for its parameterization often only con- sider the action of a single factor. This limits their adaptive capacity and often introduces considerable errors in the estimation of land surface momentum flux (friction velocity). In this study, based on research into the parameterization relations between aerodynamic roughness length and influencing factors such as windrow conditions, thermodynamic characteristics of the sur- face layer, natural rhythm of vegetation growth, ecological effects of interannual fluctuations of precipitation, and vegetation type, an aerodynamic roughness length parameterization scheme was established. This considers almost all the factors that af- fect aerodynamic roughness length on flat land surfaces with short vegetation. Furthermore, using many years' data recorded at the Semi-Arid Climate and Environment Observatory of Lanzhou University, a comparative analysis of the application of the proposed parameterization scheme and other experimental schemes was performed. It was found that the error in the friction velocity estimated by the proposed parameterization scheme was considerably less than that estimated using a constant aero- dynamic roughness length and by the other parameterization schemes. Compared with the friction velocity estimated using a constant aerodynamic roughness length, the correlation coefficient with the observed friction velocity increased from 0.752 to 0.937, and the standard deviation and deviation decreased by about 20% and 80%, respectively. Its mean value differed from the observed value by only 0.004 m s-l and the relative error was only about 1.6%, which indicates a significant decrease in the estimation error of surface-layer momentum flux. The test results show that the multifactorial universal parameterization scheme of aerodynamic roughness length for flat land surfaces with short vegetation can offer a more scientific parameteriza- tion scheme for numerical atmospheric models.展开更多
Land surface process modeling of high and cold area with vegetation cover has not yielded satisfactory results in previous applications. In this study, land surface energy budget is simulated using a land surface mode...Land surface process modeling of high and cold area with vegetation cover has not yielded satisfactory results in previous applications. In this study, land surface energy budget is simulated using a land surface model for the A'rou meadow in the upper-reach area of the Heihe River Basin in the eastern Tibetan Plateau. The model performance is evaluated using the in-situ observations and remotely sensed data. Sensible and soil heat fluxes are overestimated while latent heat flux is underestimated when the default parameter setting is used. By analyzing physical and physiological processes and the sensitivities of key parameters, the inappropriate default setting of optimum growth and inhibition temperatures is identified as an important reason for the bias. The average daytime temperature during the period of fastest vegetation growth(June and July) is adopted as the optimum growth temperature, and the inhibition temperatures were adjusted using the same increment as the optimum temperature based on the temperature acclimation. These adjustments significantly reduced the biases in sensible, latent, and soil heat fluxes.展开更多
Climate drift refers to spurious long-term changes that may be inherent in coupled models when external forcing factors are fixed. Understanding the sources of this drift and tuning the drift are crucial for obtaining...Climate drift refers to spurious long-term changes that may be inherent in coupled models when external forcing factors are fixed. Understanding the sources of this drift and tuning the drift are crucial for obtaining reasonable simulations from coupled models. To prepare for the upcoming Coupled Model Intercomparison Project Phase 6, a new coupled model has been constructed based on the Community Earth System Model and the Grid-point Atmospheric Model of IAP LASG version 2. However, the surface temperature predicted by the new model is too underestimated, and this underestimation is caused by a type of climate drift, i.e., ‘‘initial shock.'' This study analyzes the source of the cold surface temperature from the perspective of energy balance and attempts to reduce the surface temperature drift by tuning the relative humidity threshold for low cloud.展开更多
How would typhoon activity over the western North Pacific change for various scenarios of future global warming?Using the model projections of the Coupled Model Intercomparison Project phase 3(CMIP 3)under the SRES A1...How would typhoon activity over the western North Pacific change for various scenarios of future global warming?Using the model projections of the Coupled Model Intercomparison Project phase 3(CMIP 3)under the SRES A1B scenario,we generated summer(September)ice-free Arctic conditions,also referred to as Blue Arctic conditions,and then used the corresponding monthly sea surface temperature(SST)and a set of CO2concentrations to drive an AGCM model to simulate the resulting changes in background conditions affecting typhoon activity over the western North Pacific.Our results show that,during typhoon season(June to October),atmospheric and ocean circulations over the western North Pacific would be significantly different from the present circulations.Changes in the vertical shear of zonal wind and outgoing longwave radiation(OLR)in the western North Pacific are favorable for westward and northward shift,respectively,of the location of typhoon genesis.Moreover,changes in the above fields over the key area may be conducive to less frequent typhoons.In addition,the tropical cyclone genesis potential index(GPI)over the western North Pacific would decrease(increase)east(west)of 150°E(140°E).展开更多
基金Supported by A grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A092258)FG08-11-06 of the 21C Frontier Functional Human Genome Project from the Ministry of Education, Science and Technology
文摘AIM: To explore the expression pattern of E2F5 in primary hepatocellular carcinomas (HCCs) and elucidate the roles of E2F5 in hepatocarcinogenesis. METHODS: E2F5 expression was analyzed in 120 primary HCCs and 29 normal liver tissues by immunohistochemistry analysis. E2F5-small interfering RNA was transfected into HepG2, an E2F5-overexpressed HCC cell line. After E2F5 knockdown, cell growth capacity and migrating potential were examined. RESULTS: E2F5 was significantly overexpressed in primary HCCs compared with normal liver tissues (P = 0.008). The E2F5-silenced cells showed significantly reduced proliferation (P = 0.004). On the colony formation and soft agar assays, the number of colonies was significantly reduced in E2F5-silenced cells (P = 0.004 and P = 0.009, respectively). E2F5 knockdown resulted in the accumulation of G0/G1 phase cells and a reduction of S phase cells. The number of migrating/invading cells was also reduced after E2F5 knockdown (P = 0.021). CONCLUSION: To our knowledge, this is the first evidence that E2F5 is commonly overexpressed in primary HCC and that E2F5 knockdown significantly repressed the growth of HCC cells.
文摘Multimode interference (MMI) devices are widely used in planar lightwave circuit (PLC). The device length can be well reduced with tapered multimode region. Traditional design formula shows large error for MMI devices based on weakly- restricted waveguide. Based on the analysis with mode width as a substitution of waveguide width, a design formula with better precision was presented. Comparison with software simulation verified its exactness.
文摘Climatic factor's effect was studied on the radial growth of teak (Tectona grandis L.F.) by using the stem analysis of 36 trees distributed in 6 plantations in Parakou and Tchaourou districts in northern Benin. The results showed that the plantations of Parakou were in general more productive than those of Tchaourou. The annual average growth was estimated in the first five years at 0.86 cm/year for Parakou and 0.76 cm/year at Tchaourou. The analysis of the radial growth showed that a significant percentage of the variance was allotted to the growth model. It follows that a big part of the ring width was predetermined before the intervention of the other factors, in particular the climatic conditions. The percentage of the variance related to the climatic conditions was thus more reduced for the plantations of Tchaourou than those of Parakou. The radial growth was influenced by the conditions of humidity (evapotranspiration, humidity and rain) of February to May on the one hand and those from August to October on the other hand.
基金supported by the Fundamental Research Funds for the Central Universities(2017YJS168)
文摘A simultaneous visualization and measurement experiment was carried out to investigate condensation flow pat- terns and condensing heat transfer characteristics of refrigerant R14 lb in parallel horizontal multi-channels with liquid-vapor separator. The hydraulic diameter of each channel was 1.5 mm and the channel length was 100 ram. The refrigerant vapor flowing in the small channels was cooled by cooling water. The parallel horizontal mul- ti-channels were covered with a transparent silica glass for visualization of flow patterns. Experiments were per- formed at different inlet superheat temperatures (ranging from 3~C to 7~C). Mass velocity was in the range of 82.37 kg mZs1 to 35.56 kg m-2s1. It was found that there were three different flow patterns through the mul- ti-channels with the increase of mass velocity. The flow patterns in each channel pass almost tended to be same and all of them were annular flows.' The efficiency of the liquid-vapor separator with U-type was related to vapor mass velocity and the pressure in the small channels. It was also found that the heat transfer coefficient increased with the increase of the mass velocity while the cooling water mass flow rate increased. It increased to a top point and then decreased. It increased with the increase of superheat in the low superheat temperature region.
基金supported by State Key Program of National Natural Science Foundation of China(Grant No.40830957)
文摘Aerodynamic roughness length is an important physical parameter in atmospheric numerical models and microme- teorological calculations, the accuracy of which can affect numerical model performance and the level of micrometeorological computations. Many factors influence the aerodynamic roughness length, but formulas for its parameterization often only con- sider the action of a single factor. This limits their adaptive capacity and often introduces considerable errors in the estimation of land surface momentum flux (friction velocity). In this study, based on research into the parameterization relations between aerodynamic roughness length and influencing factors such as windrow conditions, thermodynamic characteristics of the sur- face layer, natural rhythm of vegetation growth, ecological effects of interannual fluctuations of precipitation, and vegetation type, an aerodynamic roughness length parameterization scheme was established. This considers almost all the factors that af- fect aerodynamic roughness length on flat land surfaces with short vegetation. Furthermore, using many years' data recorded at the Semi-Arid Climate and Environment Observatory of Lanzhou University, a comparative analysis of the application of the proposed parameterization scheme and other experimental schemes was performed. It was found that the error in the friction velocity estimated by the proposed parameterization scheme was considerably less than that estimated using a constant aero- dynamic roughness length and by the other parameterization schemes. Compared with the friction velocity estimated using a constant aerodynamic roughness length, the correlation coefficient with the observed friction velocity increased from 0.752 to 0.937, and the standard deviation and deviation decreased by about 20% and 80%, respectively. Its mean value differed from the observed value by only 0.004 m s-l and the relative error was only about 1.6%, which indicates a significant decrease in the estimation error of surface-layer momentum flux. The test results show that the multifactorial universal parameterization scheme of aerodynamic roughness length for flat land surfaces with short vegetation can offer a more scientific parameteriza- tion scheme for numerical atmospheric models.
基金supported by the National Natural Science Foundation of China(Grant Nos.91125002,40971221)FP7 CEOP-AEGI(Coordinated Asia European Long-Term Observing System of the Qinhai Tibet Plateau Hydro-meteorological Processes and the Asian Monsoon System with Ground Satellite Image data and numerical simulation)project
文摘Land surface process modeling of high and cold area with vegetation cover has not yielded satisfactory results in previous applications. In this study, land surface energy budget is simulated using a land surface model for the A'rou meadow in the upper-reach area of the Heihe River Basin in the eastern Tibetan Plateau. The model performance is evaluated using the in-situ observations and remotely sensed data. Sensible and soil heat fluxes are overestimated while latent heat flux is underestimated when the default parameter setting is used. By analyzing physical and physiological processes and the sensitivities of key parameters, the inappropriate default setting of optimum growth and inhibition temperatures is identified as an important reason for the bias. The average daytime temperature during the period of fastest vegetation growth(June and July) is adopted as the optimum growth temperature, and the inhibition temperatures were adjusted using the same increment as the optimum temperature based on the temperature acclimation. These adjustments significantly reduced the biases in sensible, latent, and soil heat fluxes.
基金supported by the CAS Strategic Priority Research Program (XDA05110304)the National 973 Basic Research Program of China (2015CB954102)the National Natural Science Foundation of China (41330527, 41205079, and 41305040)
文摘Climate drift refers to spurious long-term changes that may be inherent in coupled models when external forcing factors are fixed. Understanding the sources of this drift and tuning the drift are crucial for obtaining reasonable simulations from coupled models. To prepare for the upcoming Coupled Model Intercomparison Project Phase 6, a new coupled model has been constructed based on the Community Earth System Model and the Grid-point Atmospheric Model of IAP LASG version 2. However, the surface temperature predicted by the new model is too underestimated, and this underestimation is caused by a type of climate drift, i.e., ‘‘initial shock.'' This study analyzes the source of the cold surface temperature from the perspective of energy balance and attempts to reduce the surface temperature drift by tuning the relative humidity threshold for low cloud.
基金supported by the National Basic Research Program of China (Grant No. 2012CB955401)the National Natural Science Foundation of China (Grant No. 41130103)Norwegian Research Council project "East-Asia DecCen"
文摘How would typhoon activity over the western North Pacific change for various scenarios of future global warming?Using the model projections of the Coupled Model Intercomparison Project phase 3(CMIP 3)under the SRES A1B scenario,we generated summer(September)ice-free Arctic conditions,also referred to as Blue Arctic conditions,and then used the corresponding monthly sea surface temperature(SST)and a set of CO2concentrations to drive an AGCM model to simulate the resulting changes in background conditions affecting typhoon activity over the western North Pacific.Our results show that,during typhoon season(June to October),atmospheric and ocean circulations over the western North Pacific would be significantly different from the present circulations.Changes in the vertical shear of zonal wind and outgoing longwave radiation(OLR)in the western North Pacific are favorable for westward and northward shift,respectively,of the location of typhoon genesis.Moreover,changes in the above fields over the key area may be conducive to less frequent typhoons.In addition,the tropical cyclone genesis potential index(GPI)over the western North Pacific would decrease(increase)east(west)of 150°E(140°E).