参花心脑康胶囊对老年稳定型心绞痛的临床疗效

参花心脑康胶囊是我院制剂室依据临床协定处方自制,经武警总部卫生部批准(批准文号:武制字第2012F50004)医院院内制剂,主要用于心脑供血不足、动脉硬化、脑血栓、脑梗死等的辅助治疗,取得满意效果〔1〕;为进一步探究其临床疗效,协同本院心内科共同设计随机、双盲、模拟剂平行对照试验,对该制剂对冠心病稳定性心绞痛临床观察。1资料与方法1.

Non-Destructive Parameters Extraction for a Novel IGBT SPICE Model and Verified with Measurements

An IGBT subcircuit model is proposed and optimized,which is fully SPICE compatible.Based on analytical equations describing the semiconductor device physics,the model parameters are extracted accurately from the measured data without device destruction.The IGBT n - layer conductivity modulated resistor is effectively modeled as a voltage controlled resistor.The proposed model can be used to accurately predict the IGBT output I-V characteristics and low current gain etc.The simulation results are verified by the comparison with measurements and found to be in good agreement with them.The error in average is within 8%,which is better than the results of semi-mathematical models reported previously.

SOI MOSFET Model Parameter Extraction via a Compound Genetic Algorithm

We improve the genetic algorithm by combining it with a simulated annealing algorithm. The improved algorithm is used to extract model parameters of SOI MOSFETs, which are fabricated with standard 1.2μm CMOS/SOI technology developed by the Institute of Microelectronics of the Chinese Academy of Sciences. The simulation results using this model are in excellent agreement with experimental results. The precision is improved noticeably compared to commercial software. This method requires neither a deeper understanding of SOl MOSFETs model nor more complex computations than conventional algorithms used by commercial software. Comprehensive verification shows that this model is applicable to a very large range of device sizes.

CFD numerical simulation of flow velocity characteristics of hydrocyclone

A CFD based numerical simulation of flow velocity of hydrocyclone was conducted with different structural and operational parameters to investigate its distribution characteristics and influencing mechanism. The results show there exist several unsymmetrical envelopes of equal vertical velocities in both upward inner flows and downward outer flows in the hydrocyclone, and the cone angle and apex diameter have remarkable influence on the vertical location of the cone bottom of the envelope of zero vertical velocity. It is also found that the tangential velocity isolines exist in the horizontal planes located in the effective separation region of hydrocyclone. The increase of feed pressure has almost no effect on the distribution characteristics of both vertical velocity and tangential velocity in hydrocyclone, but the magnitude and gradient of tangential velocity are increased obviously to make the motion velocity of high density particles to the wall increased and to make the cyclonic separation effect improved.

Parameter optimization for improved aerodynamic performance of louver-type wind barrier for train-bridge system

To improve the safety of trains running in an undesirable wind environment,a novel louver-type wind barrier is proposed and further studied in this research using a scaled wind tunnel simulation with 1:40 scale models.Based on the aerodynamic performance of the train-bridge system,the parameters of the louver-type wind barrier are optimized.Compared to the case without a wind barrier,it is apparent that the wind barrier improves the running safety of trains,since the maximum reduction of the moment coefficient of the train reaches 58%using the louver-type wind barrier,larger than that achieved with conventional wind barriers(fence-type and grid-type).A louver-type wind barrier has more blade layers,and the rotation angle of the adjustable blade of the louver-type wind barrier is 90–180°(which induces the flow towards the deck surface),which is more favorable for the aerodynamic performance of the train.Comparing the 60°,90°and 120°wind fairings of the louver-type wind barrier blade,the blunt fairing is disadvantageous to the operational safety of the train.

Finite Element Numerical Simulation of Ground Subsidence in Liangjia Colliery

Being aimed at the ground subsidence due to underground coal mining,a numerical model of rock was established and an appropriate method of numerical simulation was put forward.Using the measured subsidence data on the ground,the equivalent mechanical parameters of the rock stratums can be back-calculated by the properly treatment of coal excavation area,then the ground subsidence of other coal mining area can be predicted by FFM.It provided reference for the treatment of the buildings on the ground of this colliery.

Application of orthogonal experimental design and Tikhonov regularization method for the identification of parameters in the casting solidification process

The inverse heat conduction method is one of methods to identify the casting simulation parameters. A new inverse method was presented according to the Tikhonov regularization theory. One appropriate regularized functional was established, and the functional was solved by the sensitivity coefficient and Newtonaphson iteration method. Moreover, the orthogonal experimental design was used to estimate the appropriate initial value and variation domain of each variable to decrease the number of iteration and improve the identification accuracy and efficiency. It illustrated a detailed case of AlSiTMg sand mold casting and the temperature measurement experiment was done. The physical properties of sand mold and the interracial heat transfer coefficient were identified at the meantime. The results indicated that the new regularization method was efficient in overcoming the ill-posedness of the inverse heat conduction problem and improving the stability and accuracy of the solutions.

Ventilation control of tunnel drilling dust based on numerical simulation

In order to control the dust pollution produced by air leg rock drill in the trolley area during the excavation of long-distance single ended tunnel,the full-scale physical model of working face was established by using FLUENT software,and the numerical simulation analysis of tunnel drilling ventilation and dust removal parameters was carried out.The results show that it is difficult to control the dust pollution of the face by conventional ventilation,and the drilling dust is distributed in the range of 10 m from the face;after the introduction of the long pressure and short suction ventilation scheme,when the ratio of compressed air volume to exhaust air volume is 0.72,the height of the pressure fan is 2.5 m,the distance between the pressure fan and the palm face is 20 m,and the exhaust fan is 12 m away from the palm,the dust concentration control efficiency of the working face is increased by about 60%.Therefore,in the similar long-distance single head tunnel construction,it is appropriate to adopt the dust removal method of long-distance short suction and exhaust fan to ensure the working environment.

Cutting parameter optimization for one-step shaft excavation technique based on parallel cutting method

The outcome of the cutting blasting in a one-step shaft excavation is heavily related to the cutting parameters used for parallel cutting method. In this study, the relationships between the cutting parameters（such as the hole spacing L and the empty hole diameter D） and damage zones were investigated by numerical simulation. A damage state index γ was introduced and used to characterize the crushing and crack damage zones through a user-defined subroutine. Two indices, i.e., η1 and η2 that can reflect the cutting performance, were also introduced. The simulation results indicate that an optimal value of L can be obtained so that the η1 and η2 can reach their optimal states for the best cutting performance. A larger D results in better cutting performance when the L value maintains its best. In addition, the influences of the loading rate and the in-situ stress on the cutting performance were investigated. It is found that an explosive with a high loading rate is suit for cutting blasting. The propagation direction and the length of the tensile cracks are affected by the direction and the magnitude of the maximum principal stress.

Solution of Terzaghi one-dimensional consolidation equation with general boundary conditions

Boundary conditions for the classical solution of the Terzaghi one-dimensional consolidation equation conflict with the equation＇s initial condition. As such, the classical initial-boundary value problem for the Terzaghi one-dimensional consolidation equation is not well-posed. Moreover, the classical boundary conditions of the equation can only be applied to problems with either perfectly pervious or perfectly impervious boundaries. General boundary conditions are proposed to overcome these shortcomings and thus transfer the solution of the Terzaghi one-dimensional consolidation equation to a well-posed initial boundary value problem. The solution for proposed general boundary conditions is validated by comparing it to the classical solution. The actual field drainage conditions can be simulated by adjusting the values of parameters b and c given in the proposed general botmdary conditions. For relatively high coefficient of consolidation, just one term in series expansions is enough to obtain results with acceptable accuracy.

Simulation of the relationship between roadway dynamic destruction and hypocenter parameters

Many factors can induce rock burst. Shock energy and shock distance are two key factors affecting rock burst. The 32101 roadway of the Xingcun coal mine, which has a tendency for rock burst, was used as an example. The dynamic module of Itasca’s FLAC (Fast Lagrangian Analysis of Continua) 2D explicit finite-difference software was used to simulate the roadway’s destruction. The vibration velocity and displacements of the rock surrounding the roadway were modeled for different shock energies and hypocenter distances. The simulation results indicate that the vibration velocity and displacement of rock surrounding the roadway have a quadratic relationship to the shock energy and a power law relationship to the distance of the hypocenter from the roadway. A dynamic view of the process was obtained from a series of "snap-shots" collected at 100 different time steps. This shows an isolating "river" is first formed at the hypocenter. The region above the "river" is a low stress zone while below the "river" a high stress zone exists. This high stress zone surrounds the ribs of the roadway in a "double ear" pattern. Continuous and repeated action of the high stress in the "double ear" shaped zone destroys the roadway.

Blade Shape Optimization of Liquid Turbine Flow Sensor

Based on the characteristic curve analysis, the method using D(K^2) square difference of meter factor at different flow rates was developed to evaluate the performance of turbine flow sensor in this study. Then according to the distribution of entrance velocity, it was supposed that reducing the blade area near the tip could decrease the linearity error of a sensor. Therefore, the influence of different blade shape parameters on the performance of the sensor was investigated by combining computational fluid dynamics(CFD)simulation with experimental test. The experimental results showed that, for the liquid turbine flow sensor with a diameter of 10 mm, the linearity error was smallest, and the performance of sensor was optimal when blade shape parameter equaled 0.25.

Simulation of Cefoselis hydrochloride adsorption on macroporous resin in a fixed-bed column using orthogonal collocation

Adsorption operation is of great importance for separation and purification of semi-synthetic cephalosporin compounds in pharmaceutical industry. The adsorption dynamics of Cefoselis hydrochloride(CFH) on XR 920 C adsorbent in fixed bed was predicted by the model of modified film-pore diffusion(MFPD). The intraparticle diffusion equation and mass balance equation in fixed bed are discretized into two ordinary differential equations(ODEs) using the method of orthogonal collocation which largely improves the calculation accuracy. The MFPD model parameters including the pore diffusion coefficient(Dp), external mass-transfer coefficient(kf), and the axial dispersion(DL) were estimated. The kfvalue was calculated by the Carberry equation, in which the effective diffusion coefficient Dewas fitted based on Crank Model through experimental data. Moreover, three key operating parameters(i.e., initial adsorbate concentration; flow rate of import feed, and bed height of adsorbent) and the corresponded breakthrough curves were systematically studied and optimized. Therefore,this research not only provides valuable experimental data, but also a successfully mathematical model for designing the continuous chromatographic adsorption process of CFH.

A Statistical Power Comparison of the Kolmogorov-Smirnov Two-Sample Test and the Wald Wolfowitz Test in Terms of Fixed Skewness and Fixed Kurtosis in Large Sample Sizes

In this study, the statistical powers of Kolmogorov-Smimov two-sample （KS-2） and Wald Wolfowitz （WW） tests, non-parametric tests used in testing data from two independent samples, have been compared in terms of fixed skewness and fixed kurtosis by means of Monte Carlo simulation. This comparison has been made when the ratio of variance is two as well as with equal and different sample sizes for large sample volumes. The sample used in the study is： （25, 25）, （25, 50）, （25, 75）, （25, 100）, （50, 25）, （50, 50）, （50, 75）, （50, 100）, （75, 25）, （75, 50）, （75, 75）, （75, 100）, （100, 25）, （100, 50）, （100, 75）, and （100, 100）. According to the results of the study, it has been observed that the statistical power of both tests decreases when the coefficient of kurtosis is held fixed and the coefficient of skewness is reduced while it increases when the coefficient of skewness is held fixed and the coefficient of kurtosis is reduced. When the ratio of skewness is reduced in the case of fixed kurtosis, the WW test is stronger in sample volumes （25, 25）, （25, 50）, （25, 75）, （25, 100）, （50, 75）, and （50, 100） while KS-2 test is stronger in other sample volumes. When the ratio of kurtosis is reduced in the case of fixed skewness, the statistical power of WW test is stronger in volume samples （25, 25）, （25, 75）, （25, 100）, and （75, 25） while KS-2 test is stronger in other sample volumes.

Impacts of salinity parameterizations on temperature simulation over and in a hypersaline lake

In this paper,we introduced parameterizations of the salinity effects(on heat capacity,thermal conductivity,freezing point and saturated vapor pressure) in a lake scheme integrated in the Weather Research and Forecasting model coupled with the Community Land Model(WRF-CLM). This was done to improve temperature simulation over and in a saline lake and to test the contributions of salinity effects on various water properties via sensitivity experiments. The modified lake scheme consists of the lake module in the CLM model,which is the land component of the WRF-CLM model. The Great Salt Lake(GSL) in the USA was selected as the study area. The simulation was performed from September 3,2001 to September 30,2002. Our results show that the modif ied WRF-CLM model that includes the lake scheme considering salinity effects can reasonably simulate temperature over and in the GSL. This model had much greater accuracy than neglecting salinity effects,particularly in a very cold event when that effect alters the freezing point. The salinity effect on saturated vapor pressure can reduce latent heat flux over the lake and make it slightly warmer. The salinity effect on heat capacity can also make lake temperature prone to changes. However,the salinity effect on thermal conductivity was found insignificant in our simulations.

Investigation on and industrial application of degrading of methanol feed in methanol to propylene process

At present, methanol to propylene(MTP) technology developed by Lurgi Company is adopted for commercial plants and refined methanol with the purity ≥99.85 wt% is required as the feed of MTP unit in Lurgi's technology.Therefore, high energy cost for refined methanol production is one of the bottlenecks to improve the economy of MTP technology. Reducing the grade of feed refined methanol may be an effective method to save energy and reduce operation costs in MTP process. In this work, experiments and process simulation were carried out to investigate the influence and feasibility of degrading the methanol feed. Experiments were conducted to investigate the influence of crude methanol feed on conversion and selectivity of MTP reaction as well as the performance of ZSM-5 catalyst. The experimental results showed that degrading the methanol feed had no obvious influence on the conversion and selectivity of MTP reactions and the catalyst deactivation was caused by the carbon accumulation and metals deposition on the active sites. The process simulation results showed that the influence on the conversion and selectivity as well as the stream load of MTP process was negligible if 98 mol% methanol was used as feed. Finally, industrial experiments were conducted by adjusting the operation parameters to degrade of feed methanol of the commercial 500 kt·a^(-1) MTP unit of Ningmei Group in China. The results of industrial application illustrated that annually 180 kt fuel coal and 150 kt desalted water as well as 1770 MW·h^(-1) electricity would be saved when the water content increased from 0.01% to 0.4%. This work has identified the feasibility to improve MTP technology by degrading the methanol feed.

Relationship between rectification moment and angle of shield based on numerical simulation

The finite element method is used to simulate the rectification process of shield machine, to study the relationship between rectification moment and angle and to explore the influence laws of different soil parameters and buried depth on rectification moment. It is hoped that the reference value of rectification moment can be offered to operator, and theoretical foundation can be laid for future automatic rectification technology. The results show that the rectification moment and angle generally exhibit good linear behavior in clay layers with different soil parameters or buried depths, and then the concept of rectification coefficient, that is, the ratio of rectification angle to rectification moment, is proposed; different soil parameters and buried depths have different influences on rectification coefficient, in which elastic modulus has great influence but others have little influences; the simulations of rectification process are preformed in clay layers with different elastic modulus, and fitting results show that elastic modulus and rectification coefficient present the quadratic function relation.

Adaptive polarization i mage fusion based on regional energy dynamic weighted average

According to the principle of polarization imaging and the relation between Stokes parameters and the degree of linear polarization, there are much redundant and complementary information in polarized images. Since man-made objects and natural objects can be easily distinguished in images of degree of linear polarization and images of Stokes parameters contain rich detailed information of the scene, the clutters in the images can be removed efficiently while the detailed information can be maintained by combining these images. An algorithm of adaptive polarization image fusion based on regional energy dynamic weighted average is proposed in this paper to combine these images. Through an experiment and simulations,most clutters are removed by this algorithm. The fusion method is used for different light conditions in simulation, and the influence of lighting conditions on the fusion results is analyzed.

Simulation Study on Influence of Rake Angle in Gear Skiving Processes

Gear skiving is a promising gear cutting technology that can achieve a multiple faster internal gear cutting process than that of gear shaping. However,the kinematic system complicates skiving process,resulting in severe crater wear due to the intense variation of local cutting features. In particular,the negative rake angle near the cut-out is recognized as influential factor affecting the cutter wear progress,which needs the sophisticated simulation approach to elucidate the underlying cutting mechanism. In this research,the influence of the rake angle,e.g. top and side nominal rake angles of the cutter,is studied to further understand its role in the gear skiving process,for seeking the possibility of skiving process improvement by calculating the effective rake angle. As a result,the top and side rake angles of the cutter can both increase the effective rake angle when compared with the case of the none-rake angle,leading to an enhanced skiving process. This work provides fundamental knowledge of the rake angle for the gear skiving research,contributing to the optimization on the cutter parameters by considering the effective rake angle.

Parameter fitting of constitutive model and FEM analysis of solder joint thermal cycle reliability for lead-free solder Sn-3.5Ag

The experimental tests of tensile for lead-flee solder Sn-3.5Ag were performed for the general work temperatures range from 11 to 90 ℃ and strain rate range from 5 × 10^-5 to 2 × 10^-2s^-1, and its stress--strain curves were compared to those of solder Sn-37Pb. The parameters in Anand model for solder Sn-3.5Ag were fitted based on experimental data and nonlinear fitting method, and its validity was checked by means of experimental data. Furthermore, the Anand model was used in the FEM analysis to evaluate solder joint thermal cycle reliability. The results show that solder Sn-3.5Ag has a better creep resistance than solder Sn-37Pb. The maximum stress is located at the upper right comer of the outmost solder joint from the symmetric center, and thermal fatigue life is predicted to be 3.796 × 10^4 cycles under the calculated conditions.