Local governments have long been ardently pursuing the industrial specialization effect(MAR externalities) and industrial diversification effect(Jacobs externalities). Such a pursuit has resulted in severe distortion ...Local governments have long been ardently pursuing the industrial specialization effect(MAR externalities) and industrial diversification effect(Jacobs externalities). Such a pursuit has resulted in severe distortion of resource allocation and negative effect on sustainability of local economic development. Regarding the effect from both MAR and Jacobs externalities on local economic development existing literature records notable disputes. Therefore, for local economic development, one important issue is which externality(MAR or Jacobs) can better bring the effect into play. By studying a panel data of 283 Chinese cities from 2003 to 2012 and applying dynamic plane data GMM method, this paper conducted a regression analysis of the relationship among industrial agglomeration externalities, city size, and regional economic development. The result indicates that with regard to the whole nation, MAR externalities are conducive to regional economy development whereas Jacobs externalities will, to an extent, restrain regional economic development. As regards eastern, middle, and western regions, MAR externalities are conducive only to the economic development of the eastern region; their effects on middle and western regions are insignificant. Moreover, the interaction item between MAR externalities and city size has a significant negative synergistic effect on national economic development and a certain acceleration effect on eastern region as well as a strong negative synergistic effect on the middle region and an insignificant effect on the western region. The interaction item between Jacobs externalities and city size has a positive synergistic effect on only the middle region and has an insignificant synergistic effect on both eastern and western regions. Capital stock and labor input have significant accelerating effects on GDP growth per capita of Chinese cities, whereas material capital and labor input remain primary driving forces for Chinese local economic development. Furthermore, human capital contributes to accelerating urban economic development, whereas government intervention restrains urban economic development.展开更多
OBJECTIVE: To investigate the anti-platelet aggregation and antithrombotic effects in rats of iridoid glycosides extracted from Zhizi (FructusGardeniae). METHODS: The present study evaluated the antithrombotic activit...OBJECTIVE: To investigate the anti-platelet aggregation and antithrombotic effects in rats of iridoid glycosides extracted from Zhizi (FructusGardeniae). METHODS: The present study evaluated the antithrombotic activity of iridoid glycosides (IGs) in a rat model of carotid artery thrombosis. The effects on coagulation, such as thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT), and the effect on collagen-induced platelet aggregation in vivo were investigated. Rats were intragastrically administered IGs (50, 100 or 200 mg/ kg) twice daily for 3 days. RESULTS: IGs were shown for the first time to have an antithrombotic action through the inhibition of platelet aggregation, with little effect on the coagulation time of peripheral blood. Our results also showed that IGs may significantly and dose-dependently reduce arterial thrombus load in a model of carotid artery thrombosis and inhibit collagen-induced platelet aggregation in rats. IGs (100or 200 mg/kg) had no significant effect on APTT and PT, but did lengthenTT at a higher dose. CONCLUSION: These data, together with the previously reported neuroprotective effects of IGs in rats with cerebral ischemia, suggest that the antithrombotic action of IGs may potentially contribute to the treatment of cerebral ischemic diseases, including cerebral apoplexy.展开更多
Deepwater offshore structures such as semi-submersible platforms suffer powerful ocean waves due to their location and site condition. The long distance away from the shore also brings many difficulties to energy supp...Deepwater offshore structures such as semi-submersible platforms suffer powerful ocean waves due to their location and site condition. The long distance away from the shore also brings many difficulties to energy supply for the platform operation. How to reduce the response of the platform and convert the wave energy into electrical power is a meaningful topic. In this paper, a tuned heave plate system(THP) is presented and designed to be employed on a semi-submersible platform for heave motion suppression and energy harvesting. This THP system is composed of spring supports, a power take-off system(PTO), and a heave plate. The PTO system is a permanent magnet linear generator(PMLG), which could directly convert the kinetic energy of the heave plate into electronic power. The stiffness of the spring supports is designed based on the principle of the tuned mass damper(TMD). The numerical model of the platform and the THP system is established according to the hydrodynamic analysis results of the platform. The model is tested and modified by scale model tests on the platform in the wave tank. A parameter study, including the size, tuned period, and damping ratio of the THP system, is conducted systematically based on the numerical model. The optimal parameters of the THP are selected due to the maximum heave motion reduction under severe wave conditions in South China Sea. The performance of the semi-submersible with and without the THP system under different wave conditions is analyzed. It is demonstrated that this novel tuned heave plate system could reduce the heave motion of the semi-submersible platform significantly and generate considerable power, which makes the THP system have a broad prospect for development.展开更多
基金Under the auspices of National Natural Science Foundation of China(No.41571112)Natural Science Foundation of Zhejiang Province of China(No.LY16D010002)
文摘Local governments have long been ardently pursuing the industrial specialization effect(MAR externalities) and industrial diversification effect(Jacobs externalities). Such a pursuit has resulted in severe distortion of resource allocation and negative effect on sustainability of local economic development. Regarding the effect from both MAR and Jacobs externalities on local economic development existing literature records notable disputes. Therefore, for local economic development, one important issue is which externality(MAR or Jacobs) can better bring the effect into play. By studying a panel data of 283 Chinese cities from 2003 to 2012 and applying dynamic plane data GMM method, this paper conducted a regression analysis of the relationship among industrial agglomeration externalities, city size, and regional economic development. The result indicates that with regard to the whole nation, MAR externalities are conducive to regional economy development whereas Jacobs externalities will, to an extent, restrain regional economic development. As regards eastern, middle, and western regions, MAR externalities are conducive only to the economic development of the eastern region; their effects on middle and western regions are insignificant. Moreover, the interaction item between MAR externalities and city size has a significant negative synergistic effect on national economic development and a certain acceleration effect on eastern region as well as a strong negative synergistic effect on the middle region and an insignificant effect on the western region. The interaction item between Jacobs externalities and city size has a positive synergistic effect on only the middle region and has an insignificant synergistic effect on both eastern and western regions. Capital stock and labor input have significant accelerating effects on GDP growth per capita of Chinese cities, whereas material capital and labor input remain primary driving forces for Chinese local economic development. Furthermore, human capital contributes to accelerating urban economic development, whereas government intervention restrains urban economic development.
文摘OBJECTIVE: To investigate the anti-platelet aggregation and antithrombotic effects in rats of iridoid glycosides extracted from Zhizi (FructusGardeniae). METHODS: The present study evaluated the antithrombotic activity of iridoid glycosides (IGs) in a rat model of carotid artery thrombosis. The effects on coagulation, such as thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT), and the effect on collagen-induced platelet aggregation in vivo were investigated. Rats were intragastrically administered IGs (50, 100 or 200 mg/ kg) twice daily for 3 days. RESULTS: IGs were shown for the first time to have an antithrombotic action through the inhibition of platelet aggregation, with little effect on the coagulation time of peripheral blood. Our results also showed that IGs may significantly and dose-dependently reduce arterial thrombus load in a model of carotid artery thrombosis and inhibit collagen-induced platelet aggregation in rats. IGs (100or 200 mg/kg) had no significant effect on APTT and PT, but did lengthenTT at a higher dose. CONCLUSION: These data, together with the previously reported neuroprotective effects of IGs in rats with cerebral ischemia, suggest that the antithrombotic action of IGs may potentially contribute to the treatment of cerebral ischemic diseases, including cerebral apoplexy.
基金supported by the National Natural Science Foundation of China(Grant No.50921001)the National Basic Research Program of China("973"Project)(Grant No.2011CB013705)
文摘Deepwater offshore structures such as semi-submersible platforms suffer powerful ocean waves due to their location and site condition. The long distance away from the shore also brings many difficulties to energy supply for the platform operation. How to reduce the response of the platform and convert the wave energy into electrical power is a meaningful topic. In this paper, a tuned heave plate system(THP) is presented and designed to be employed on a semi-submersible platform for heave motion suppression and energy harvesting. This THP system is composed of spring supports, a power take-off system(PTO), and a heave plate. The PTO system is a permanent magnet linear generator(PMLG), which could directly convert the kinetic energy of the heave plate into electronic power. The stiffness of the spring supports is designed based on the principle of the tuned mass damper(TMD). The numerical model of the platform and the THP system is established according to the hydrodynamic analysis results of the platform. The model is tested and modified by scale model tests on the platform in the wave tank. A parameter study, including the size, tuned period, and damping ratio of the THP system, is conducted systematically based on the numerical model. The optimal parameters of the THP are selected due to the maximum heave motion reduction under severe wave conditions in South China Sea. The performance of the semi-submersible with and without the THP system under different wave conditions is analyzed. It is demonstrated that this novel tuned heave plate system could reduce the heave motion of the semi-submersible platform significantly and generate considerable power, which makes the THP system have a broad prospect for development.
