Predicting the lifetime of polymeric insulators is one of the most important research topics in studying the life cycle of high voltage insulators in the power transmission and distribution networks. HTV (high temper...Predicting the lifetime of polymeric insulators is one of the most important research topics in studying the life cycle of high voltage insulators in the power transmission and distribution networks. HTV (high temperature vulcanized) silicone rubber is a high performance dielectric material used within electrical power equipment, in particular transmission and distribution insulators. In this paper, we proposed a new approach using the Newton's method and Lagrange method to predict the aging of HTV silicone rubber that are subjected to multiple stress conditions. Concentration of chemical elements such as carbon, oxygen, silicon and aluminum were obtained and evaluated using a SEM (scanning electron microscope) with EDS (energy dispersive X-ray spectroscopy). Curve fitting using the Newton's and Lagrange interpolation methods yield useful linear interpolation equations that describe the aging characteristic of the specimens under study. This approach can be applied to predict the change in chemical concentration of polymeric insulators over the life cycle with good accuracy.展开更多
Quercetin (Que) is a natural multifunctional bioflavonoid, and has shown great potential for reducing adverse side effects and enhancing antitumor efficacy of chemotherapeutic drugs. However, its clinical applicatio...Quercetin (Que) is a natural multifunctional bioflavonoid, and has shown great potential for reducing adverse side effects and enhancing antitumor efficacy of chemotherapeutic drugs. However, its clinical application is limited due to very low solubility and structural instability in physiological systems. Herein, we co-delivered hydrophobic quercetin and hydrophilic doxorubicin (Dox) by developing a biocompatible nanocarrier comprising of an amphiphilic polymer, methoxy poly(ethylene glycol) and poly(D, L-lactide-co-glycolide), respectively. The antitumor and prophylactic efficacy of this system was evaluated in cellular and animal models. Our findings illustrated that the Dox-Que nanoparticulate formulation protected normal vascular endothelial cells from either free or nanoparticulate doxorubicin-induced cytotoxicity and increased cancer cell death. Compared with free doxorubicin and its nanoformulation, co-delivery of quercetin and doxorubicin using our nanosystem synergistically inhibited tumor growth, while maintaining normal levels of cardiac function indicators in serum and recovering the histopathological damages in heart tissue. This study demonstrates a promising strategy for enhancing anti-cancer drug efficacy and reducing chemotherapy-induced toxicity on normal nanoparticulate tissues.展开更多
As a component of diesel exhaust particles, 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC) is also a metabolite of the insecticide fenitrothion and imposes hazardous effects on human health. In the present study, t...As a component of diesel exhaust particles, 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC) is also a metabolite of the insecticide fenitrothion and imposes hazardous effects on human health. In the present study, the alleviative effect of a common antioxidant flavonoid quercetin on mouse germ cells intoxicated by PNMC was inves- tigated. Results showed that a single intraperitoneal injection of PNMC at 100 mg/kg induced severe testicular damage after one week. PNMC-treated mice showed a significant loss of germ cells (approximate 40% loss of round germ cells). PNMC caused an increase of hydroxyl radical and hydrogen peroxide production and lipid peroxidation, as well as a decrease in glutathione level, superoxide dismutase and glutathione peroxidase activities. Furthermore, treatment of PNMC increased expression of the pro-apoptotic protein Bax and decreased expression of the anti-apoptotic protein BcI-XL in germ cells. In addition, testicular caspase-3 activity was significantly up-regulated and germ cell apoptosis was significantly increased in the PNMC-treated mice. In contrast, combined administration of quercetin at 75 mg/kg significantly attenuated PNMC-induced testicular toxicity. These results indicate that the antioxidant quercetin displays a remarkable protective effect on PNMC-induced oxidative damage in mouse testes and may represent an efficient supplement to attenuate reproductive toxicity by environmental toxicants to ensure healthy sperm production.展开更多
In contrast to Gaussian or Woods-Saxon potential a two-term four parameter nuclear Hulthdn type inter- action is considered to describe the a-a, t-a He and t=3 H systems. By exploiting the phase function method, scatt...In contrast to Gaussian or Woods-Saxon potential a two-term four parameter nuclear Hulthdn type inter- action is considered to describe the a-a, t-a He and t=3 H systems. By exploiting the phase function method, scattering phase shifts are computed up to ELb -- 100 MeV for the a-a system and ELab = 15 MeV for a-3He and a-3H systems. The S-wave phase shift 5o for the system tends to 2n and 53/2_ for thea-3He system tends to n, in the limit of zero energy. Reasonable agreements in phase shifts with the standard data are obtained with this simple potential model except for the 5/2- states of a-3He and a-3H systems, With an additional energy-dependent correction factor to our potential, a good agreement with experimental data is obtained for 5/2- states. We have also compared our results with the convenient Born approximations.展开更多
文摘Predicting the lifetime of polymeric insulators is one of the most important research topics in studying the life cycle of high voltage insulators in the power transmission and distribution networks. HTV (high temperature vulcanized) silicone rubber is a high performance dielectric material used within electrical power equipment, in particular transmission and distribution insulators. In this paper, we proposed a new approach using the Newton's method and Lagrange method to predict the aging of HTV silicone rubber that are subjected to multiple stress conditions. Concentration of chemical elements such as carbon, oxygen, silicon and aluminum were obtained and evaluated using a SEM (scanning electron microscope) with EDS (energy dispersive X-ray spectroscopy). Curve fitting using the Newton's and Lagrange interpolation methods yield useful linear interpolation equations that describe the aging characteristic of the specimens under study. This approach can be applied to predict the change in chemical concentration of polymeric insulators over the life cycle with good accuracy.
基金Acknowledgments This work was supported by the National Basic Research Program of China (2012CB934004), the National Funds for Distinguished Young Scientists (31325010), the Key Research Program of the Chinese Academy of Sciences (KGZD-EW-T06) and the National Natural Science Foundation of China (31300822).
文摘Quercetin (Que) is a natural multifunctional bioflavonoid, and has shown great potential for reducing adverse side effects and enhancing antitumor efficacy of chemotherapeutic drugs. However, its clinical application is limited due to very low solubility and structural instability in physiological systems. Herein, we co-delivered hydrophobic quercetin and hydrophilic doxorubicin (Dox) by developing a biocompatible nanocarrier comprising of an amphiphilic polymer, methoxy poly(ethylene glycol) and poly(D, L-lactide-co-glycolide), respectively. The antitumor and prophylactic efficacy of this system was evaluated in cellular and animal models. Our findings illustrated that the Dox-Que nanoparticulate formulation protected normal vascular endothelial cells from either free or nanoparticulate doxorubicin-induced cytotoxicity and increased cancer cell death. Compared with free doxorubicin and its nanoformulation, co-delivery of quercetin and doxorubicin using our nanosystem synergistically inhibited tumor growth, while maintaining normal levels of cardiac function indicators in serum and recovering the histopathological damages in heart tissue. This study demonstrates a promising strategy for enhancing anti-cancer drug efficacy and reducing chemotherapy-induced toxicity on normal nanoparticulate tissues.
基金Project supported by the National Natural Science Foundation of China (No.31001041)the Chinese Universities Scientific Fund and Project of the Bureau of Education of Zhejiang Province (No.Y201018833),China
文摘As a component of diesel exhaust particles, 3-methyl-4-nitrophenol (4-nitro-m-cresol, PNMC) is also a metabolite of the insecticide fenitrothion and imposes hazardous effects on human health. In the present study, the alleviative effect of a common antioxidant flavonoid quercetin on mouse germ cells intoxicated by PNMC was inves- tigated. Results showed that a single intraperitoneal injection of PNMC at 100 mg/kg induced severe testicular damage after one week. PNMC-treated mice showed a significant loss of germ cells (approximate 40% loss of round germ cells). PNMC caused an increase of hydroxyl radical and hydrogen peroxide production and lipid peroxidation, as well as a decrease in glutathione level, superoxide dismutase and glutathione peroxidase activities. Furthermore, treatment of PNMC increased expression of the pro-apoptotic protein Bax and decreased expression of the anti-apoptotic protein BcI-XL in germ cells. In addition, testicular caspase-3 activity was significantly up-regulated and germ cell apoptosis was significantly increased in the PNMC-treated mice. In contrast, combined administration of quercetin at 75 mg/kg significantly attenuated PNMC-induced testicular toxicity. These results indicate that the antioxidant quercetin displays a remarkable protective effect on PNMC-induced oxidative damage in mouse testes and may represent an efficient supplement to attenuate reproductive toxicity by environmental toxicants to ensure healthy sperm production.
文摘In contrast to Gaussian or Woods-Saxon potential a two-term four parameter nuclear Hulthdn type inter- action is considered to describe the a-a, t-a He and t=3 H systems. By exploiting the phase function method, scattering phase shifts are computed up to ELb -- 100 MeV for the a-a system and ELab = 15 MeV for a-3He and a-3H systems. The S-wave phase shift 5o for the system tends to 2n and 53/2_ for thea-3He system tends to n, in the limit of zero energy. Reasonable agreements in phase shifts with the standard data are obtained with this simple potential model except for the 5/2- states of a-3He and a-3H systems, With an additional energy-dependent correction factor to our potential, a good agreement with experimental data is obtained for 5/2- states. We have also compared our results with the convenient Born approximations.