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蛋白质结构预测的优化模型与方法 被引量:6
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作者 唐焕文 靳利霞 计明军 《工程数学学报》 CSCD 北大核心 2002年第2期13-22,共10页
从头预测方法是一种主要的蛋白质空间结构预测方法 ,其核心内容是恰当地建立并求解一个复杂的全局优化问题。 4 0年来 ,虽然也取得了许多研究成果 ,但该问题的研究始终没有克服两个方面的困难 ,即如何找到一个表征蛋白质结构与能量关系... 从头预测方法是一种主要的蛋白质空间结构预测方法 ,其核心内容是恰当地建立并求解一个复杂的全局优化问题。 4 0年来 ,虽然也取得了许多研究成果 ,但该问题的研究始终没有克服两个方面的困难 ,即如何找到一个表征蛋白质结构与能量关系的势能函数和一种有效的全局优化方法。主要介绍了蛋白质结构预测的优化模型和方法。 展开更多
关键词 蛋白质结构 预测 优化模型 从头预测 势能函数 能量极小化 橡象搜索 全局优化
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Mesomechanics coal experiment and an elastic-brittle damage model based on texture features 被引量:3
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作者 Sun Chuanmeng Cao Shugang Li Yong 《International Journal of Mining Science and Technology》 EI CSCD 2018年第4期634-642,共9页
To accurately describe damage within coal, digital image processing technology was used to determine texture parameters and obtain quantitative information related to coal meso-cracks. The relationship between damage ... To accurately describe damage within coal, digital image processing technology was used to determine texture parameters and obtain quantitative information related to coal meso-cracks. The relationship between damage and mesoscopic information for coal under compression was then analysed. The shape and distribution of damage were comprehensively considered in a defined damage variable, which was based on the texture characteristic. An elastic-brittle damage model based on the mesostructure information of coal was established. As a result, the damage model can appropriately and reliably replicate the processes of initiation, expansion, cut-through and eventual destruction of microscopic damage to coal under compression. After comparison, it was proved that the predicted overall stress-strain response of the model was comparable to the experimental result. 展开更多
关键词 Mesomechanics experiment Image processing Texture feature Damage variable Damage model
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鸡肝二氢叶酸还原酶在盐酸胍溶液中构象的序变与激活
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作者 范映辛 居鸣 +1 位作者 周筠梅 邹承鲁 《中国科学(C辑)》 CSCD 1997年第3期204-210,共7页
用蛋白质内源荧光、疏水荧光探针TNS及蛋白酶K限制性酶解等方法研究了二氢叶酸还原酶在盐酸胍变性过程中的构象变化及动力学,并与活力变化进行了比较.TNS可以监测到与激活同步的构象变化;盐酸胍浓度大于0.75mol/L时,二氢叶酸还原酶被蛋... 用蛋白质内源荧光、疏水荧光探针TNS及蛋白酶K限制性酶解等方法研究了二氢叶酸还原酶在盐酸胍变性过程中的构象变化及动力学,并与活力变化进行了比较.TNS可以监测到与激活同步的构象变化;盐酸胍浓度大于0.75mol/L时,二氢叶酸还原酶被蛋白酶K水解速度增大;当盐酸胍浓度大于1.2mol/L时,才能监测到酶分子整体构象的变化.以上结果表明二氢叶酸还原酶在盐酸胍溶液中的变性并不符合标准的二态模型,而是先经历构象逐步松散的序变过程,然后发生协同的构象伸展.二氢叶酸还原酶在低浓度盐酸胍溶液中的激活是由于酶活性部位构象的微小变化引起的.酶活性部位构象的变化虽然降低了酶与废物的结合能力,但加快了酶促反应限速步骤,即底物解离速度而使酶活力升高. 展开更多
关键词 二氢叶酸还原酶 盐酸胍 激活 橡象 序变
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Development of a Low-Cost Weather Station to Measure in Situ Essential Climate Variables
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作者 Jose I. Rojas Silvia D. Gilete Jordi Mazon 《Journal of Earth Science and Engineering》 2014年第8期455-463,共9页
A weather station is proposed especially designed for developing countries, and to meet the standards of the international scientific community making research on the earth system. The station would measure in situ se... A weather station is proposed especially designed for developing countries, and to meet the standards of the international scientific community making research on the earth system. The station would measure in situ several ECV (essential climate variables). These data may enable an agricultural breakthrough in countries lacking meteorological infrastructure, help in climate change monitoring, and facilitate diffusion of wind energy. A pre-feasibility analysis is presented. It appears interesting that the station is supplied by a social enterprise. A research to establish the best shelter design using computational fluid dynamics is also reported. The criterion is the accuracy with which the surface air temperature is reproduced inside the shelter. A design following recommendations by the WMO (World Meteorological Organization), a smaller design with identical geometry, and two alternative small designs are analyzed. All four designs are simulated in PVC, natural rubber and wood, with and without white paint coating. The smaller shelters perform better. The influence of the material, dimensions and design is smaller than that of the white paint. Shelters made of PVC or rubber, and/or in alternative designs, may be more interesting if other criteria are considered, like whether logistics, manufacturing, etc. are more sustainable, easier and/or cheaper. 展开更多
关键词 Meteorological station essential climate variable CFD (computational fluid dynamics) thermal analysis temperature.
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Cellulolytic Microbial Activator Influence on Decomposition of Rubber Factory Waste Composting
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作者 T. Kaosol S. Wandee 《Journal of Environmental Science and Engineering》 2010年第3期41-47,共7页
An aerobic composting method is studied to reuse organic waste from rubb er factory waste as soil fertilizer and to study the effect of cellulolytic microbial activator (CMA) as the activator in the rubber factory w... An aerobic composting method is studied to reuse organic waste from rubb er factory waste as soil fertilizer and to study the effect of cellulolytic microbial activator (CMA) as the activator in the rubber factory waste composting. The performance of the composting process was monitored as a function of carbon and organic matter decomposition rate, temperature and moisture content. The results indicate that the rubber factory waste is best composted with water hyacinth and sludge than composted alone. In addition, the CMA is more aft^ctive when mixed with the rubber factory waste, water hyacinth and sludge since a good fertilizer is achieved. When adding CMA into the rubber factory waste composted alone, the finished product does not achieve a standard of fertilizer, especially the C/N ratio. The finished products (both CMA and without CMA), can be an environmental friendly alternative to solve the disposal problems of rubber factory waste, Since the C/N ratio, pH, moisture content, temperature, and nutrients of the finished products are acceptable for agriculture use. 展开更多
关键词 COMPOSTING rubber waste C/N ratio SLUDGE cellulolytic microbial activator.
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