人体运动后摄氧量的变化是评价心肺功能的生理指标。为了将这一生理指标应用于临床心功能判定,本文应用西德 Jaeger 公司 EOS 心肺功能测试装置,测定152名正常成年男子不同年龄的次极量踏车运动时的摄氧量—次最大摄氧量(VO_submax)正...人体运动后摄氧量的变化是评价心肺功能的生理指标。为了将这一生理指标应用于临床心功能判定,本文应用西德 Jaeger 公司 EOS 心肺功能测试装置,测定152名正常成年男子不同年龄的次极量踏车运动时的摄氧量—次最大摄氧量(VO_submax)正常值标准,综合考虑年龄、身高、体重的影响,为临床提供了一项较为合理的心功能判定指标。展开更多
Background: Improved exercise capacity in chronic heart failure(CHF) has been attributed to restoration of endothelial function. ACE inhibitors as well as beta blockers have previously been shown to enhance endothelia...Background: Improved exercise capacity in chronic heart failure(CHF) has been attributed to restoration of endothelial function. ACE inhibitors as well as beta blockers have previously been shown to enhance endothelial function and exercise capacity. The aim of this study was to determine whether short-term improvement in submaximal exercise capacity induced by optimized therapy with ACE inhibitors in combination with beta blockers is associated with restoration of endothelial function in CHF patients. Methods: Thirty-three patients with CHF were evaluated: six-minute walk test, NYHA class, brain natriuretic peptide(BNP), big Endothelin-1(bigET-1) and flow-mediated vasodilation(FMD) of the brachial artery were assessed at baseline and after a 3-month period of optimized neurohormonal therapy. Two groups were formed retrospectively based on the changes in submaximal exercise capacity(responders and nonresponders). Results: Optimization of neurohormonal therapy was comparable between groups. Responders(n=17) revealed a significant increase in walking distance(304± 109 to 441± 75 m; p< 0.01), which was paralleled by a decrease in NYHA class(2.7± 0.6 to 2.0± 0.4; p< 0.01), BNP(484± 454 to 243± 197 pg/ml; p< 0.01), and bigET-1(2.0± 0.9 vs. 1.5± 0.6 fmol/ml; p=0.04). By contrast, the latter variables did not change in non-responders. Improvement in functional capacity in responders was associated with an increase in FMD(8.2± 3.9% to 11.0± 5.6% ; p< 0.05). Increments in FMD were directly correlated with increases in walking distance(r=0.34; p< 0.05). Conclusion: Short-term improvement of submaximal exercise capacity in CHF patients following optimized therapy with ACE inhibitors and beta blockers is associated with restoration of endothelial function in conduit arteries.展开更多
文摘人体运动后摄氧量的变化是评价心肺功能的生理指标。为了将这一生理指标应用于临床心功能判定,本文应用西德 Jaeger 公司 EOS 心肺功能测试装置,测定152名正常成年男子不同年龄的次极量踏车运动时的摄氧量—次最大摄氧量(VO_submax)正常值标准,综合考虑年龄、身高、体重的影响,为临床提供了一项较为合理的心功能判定指标。
文摘Background: Improved exercise capacity in chronic heart failure(CHF) has been attributed to restoration of endothelial function. ACE inhibitors as well as beta blockers have previously been shown to enhance endothelial function and exercise capacity. The aim of this study was to determine whether short-term improvement in submaximal exercise capacity induced by optimized therapy with ACE inhibitors in combination with beta blockers is associated with restoration of endothelial function in CHF patients. Methods: Thirty-three patients with CHF were evaluated: six-minute walk test, NYHA class, brain natriuretic peptide(BNP), big Endothelin-1(bigET-1) and flow-mediated vasodilation(FMD) of the brachial artery were assessed at baseline and after a 3-month period of optimized neurohormonal therapy. Two groups were formed retrospectively based on the changes in submaximal exercise capacity(responders and nonresponders). Results: Optimization of neurohormonal therapy was comparable between groups. Responders(n=17) revealed a significant increase in walking distance(304± 109 to 441± 75 m; p< 0.01), which was paralleled by a decrease in NYHA class(2.7± 0.6 to 2.0± 0.4; p< 0.01), BNP(484± 454 to 243± 197 pg/ml; p< 0.01), and bigET-1(2.0± 0.9 vs. 1.5± 0.6 fmol/ml; p=0.04). By contrast, the latter variables did not change in non-responders. Improvement in functional capacity in responders was associated with an increase in FMD(8.2± 3.9% to 11.0± 5.6% ; p< 0.05). Increments in FMD were directly correlated with increases in walking distance(r=0.34; p< 0.05). Conclusion: Short-term improvement of submaximal exercise capacity in CHF patients following optimized therapy with ACE inhibitors and beta blockers is associated with restoration of endothelial function in conduit arteries.
