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敌敌畏生理毒物代谢动力学模型的建立 被引量:4
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作者 梁颖 刘敏 +2 位作者 丁莹 张留娟 刘贤金 《农药学学报》 CAS CSCD 北大核心 2015年第1期35-40,共6页
利用生理毒物代谢动力学(PBTK)模型,对大鼠经口摄入敌敌畏后其在体内分布及转化代谢过程进行模拟,旨在探寻评价敌敌畏饮食暴露风险的合理方法。该PBTK模型共包括4个房室:肝脏、肾脏、充分灌注室和不充分灌注室,各房室内敌敌畏的浓度变... 利用生理毒物代谢动力学(PBTK)模型,对大鼠经口摄入敌敌畏后其在体内分布及转化代谢过程进行模拟,旨在探寻评价敌敌畏饮食暴露风险的合理方法。该PBTK模型共包括4个房室:肝脏、肾脏、充分灌注室和不充分灌注室,各房室内敌敌畏的浓度变化率采用质量守恒微分方程表示。根据欧拉数值计算方法,对大鼠经口摄入敌敌畏后的毒物代谢动力学数据进行模拟,分别预测了大鼠经口摄入10、25和50 mg/kg b.w.的敌敌畏后,肝脏和血液中敌敌畏浓度变化以及血液中乙酰胆碱酯酶活性变化的曲线。为验证该方法的准确性,将大鼠经口摄入35 mg/kg b.w.敌敌畏后血液中敌敌畏的浓度变化模拟值,以及经口摄入10 mg/kg b.w.敌敌畏后血液中乙酰胆碱酯酶活性变化的模拟值与文献的实验测量值进行了比较,结果显示,模拟值与实验值之间不存在显著性差异。因此认为,利用该PBTK模型可以估测大鼠经口摄入敌敌畏后的体内生理毒物代谢动力学数据,为评估人体的有害物质暴露内剂量数据提供了便捷途径。 展开更多
关键词 敌敌畏 生理毒物代谢动力学模型 大鼠 欧拉数值法 经口摄入
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氰戊菊酯生理毒物代谢动力学模型的建立 被引量:2
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作者 梁颖 丁莹 +1 位作者 张留圈 刘贤金 《生态毒理学报》 CAS CSCD 北大核心 2015年第3期170-176,共7页
利用生理毒物代谢动力学(PBTK)对小鼠静脉注射农药氰戊菊酯后,氰戊菊酯在体内分布转化代谢过程进行模拟,为评价农药暴露风险提供依据。小鼠静脉注射氰戊菊酯的PBTK模型构建分为5个房室:肝脏、肺、肾脏、充分灌注室和不充分灌注室,各房... 利用生理毒物代谢动力学(PBTK)对小鼠静脉注射农药氰戊菊酯后,氰戊菊酯在体内分布转化代谢过程进行模拟,为评价农药暴露风险提供依据。小鼠静脉注射氰戊菊酯的PBTK模型构建分为5个房室:肝脏、肺、肾脏、充分灌注室和不充分灌注室,各房室内氰戊菊酯的浓度变化率由质量守恒微分方程表示。根据欧拉数值计算方法,对小鼠静脉注射氰戊菊酯后的毒物代谢动力学数据进行模拟。结果模拟预测了小鼠静脉注射0.5 mg·kg-1、2.5 mg·kg-1、10 mg·kg-1氰戊菊酯后血液、肝脏和肺中氰戊菊酯浓度变化曲线。为验证该模型的准确性,对小鼠静脉注射0.77 mg·kg-1氰戊菊酯后血液、肝脏和肺中氰戊菊酯的浓度值变化模拟值与前人的实验测量值进行比较,结果显示模拟值与实验值之间不存在显著性差异。因此利用该方法可以估测小鼠静脉注射氰戊菊酯的毒物代谢动力学数据,为评估农药暴露体内剂量数据提供了便利途径。 展开更多
关键词 氰戊菊酯 生理毒物代谢动力学模型 小鼠 欧拉数值法 静脉注射
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一种计算覆冰导线局部收集系数的简化模型 被引量:1
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作者 于洋 《广东电力》 2008年第5期1-4,18,共5页
结合机翼表面覆冰时计算局部收集系数的欧拉数值法,提出一种适合覆冰导线的欧拉气液两相简化模型来计算导线表面局部收集系数。仿真实验结果表明:导线迎风面驻点两侧局部收集系数最大,上下两端最小;风速和液滴直径是影响局部收集系数的... 结合机翼表面覆冰时计算局部收集系数的欧拉数值法,提出一种适合覆冰导线的欧拉气液两相简化模型来计算导线表面局部收集系数。仿真实验结果表明:导线迎风面驻点两侧局部收集系数最大,上下两端最小;风速和液滴直径是影响局部收集系数的主要因素,水平夹角仅影响其在迎风面的分布,而空气含湿量对其无影响。比较文献数据和实验数据可知,利用该模型可准确计算覆冰条件下导线表面的局部收集系数。 展开更多
关键词 覆冰 局部收集系数 欧拉数值法
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Numerical modeling of effect of slot on bubble motion in aluminum electrolytic process 被引量:4
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作者 Qiang WANG Mei-jia SUN +2 位作者 Bao-kuan LI Guang-qiang LI Jian-ping PENG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2018年第8期1670-1678,共9页
A transient three-dimensional(3 D) model was established to understand the bubble motion in an industrial electrolytic process. An anode with a new design was tested. It incorporates two slots that allow an efficien... A transient three-dimensional(3 D) model was established to understand the bubble motion in an industrial electrolytic process. An anode with a new design was tested. It incorporates two slots that allow an efficient removal of gas bubbles. The electromagnetic fields were described by solving Maxwell's equations. The bubble movement was studied with two-way coupling Euler-Lagrange approach. The interplay of current density and bubble nucleation rate was included. The collision and coalescence of bubbles were considered. Random walk module was invoked for involving the chaotic effect of the turbulence. The numerical results were validated by experimental measurements. The results indicate that the current distribution and the bubble nucleation periodically change. Due to the slot, the bubble elimination heavily increases. The contribution of the slot to the bubble removal exceeds 50% in the case of three currents, and the promotion of the slot decays with increasing the current. 展开更多
关键词 aluminum electrolytic process anodic bubble SLOT Euler-Lagrange approach numerical simulation
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振动压路机动力学分析之时域与频域法的比较
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作者 陈琳 郑惠萍 《石家庄职业技术学院学报》 2014年第6期36-39,共4页
以振动压路机为例,对振动压路机压实过程建立了三自由度线性动力学方程,分别运用欧拉数值积分法和频域分析法进行了仿真.仿真结果显示,两种方法计算出的压路机系统响应结果一致.数值积分法所得的系统响应包含瞬态响应和稳态响应,计算时... 以振动压路机为例,对振动压路机压实过程建立了三自由度线性动力学方程,分别运用欧拉数值积分法和频域分析法进行了仿真.仿真结果显示,两种方法计算出的压路机系统响应结果一致.数值积分法所得的系统响应包含瞬态响应和稳态响应,计算时间长,对初始条件要求严格;而频域分析法得到的系统响应只有稳态响应,计算时间短,但对采样频率有一定的要求. 展开更多
关键词 振动压路机 欧拉数值积分 频域分析 动力学仿真
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A numerical study of passenger side airbag deployment based on arbitrary Lagrangian-eulerian method 被引量:4
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作者 WANG XiJun ZONG Zhi +1 位作者 ZHAO Yong ZOU Li 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2015年第3期397-404,共8页
The passenger side airbags(PAB)are usually larger than the driver airbags.Therefore,the inflator of PAB is more powerful with high mass rate.In this paper,an Arbitrary Lagrangian-Eulerian(ALE)method based computationa... The passenger side airbags(PAB)are usually larger than the driver airbags.Therefore,the inflator of PAB is more powerful with high mass rate.In this paper,an Arbitrary Lagrangian-Eulerian(ALE)method based computational method is developed to simulate the deployment of a PAB.The tank test is used to test the property of the inflator.Through comparison of numerical and experimental results,the ALE method is validated.Based on a failed airbag test,a smaller sub-airbag is placed inside PAB to disperse the gas flow to directions which are less damaging.By applying dynamic relaxation,the initial mesh corresponding to the experimental terms is obtained.The results indicate that the interior pressure and impact force coincide with the test data,and the method in this paper is capable of capturing airbag deploying process of the PAB module accurately. 展开更多
关键词 arbitrary Lagrangian-eulerian(ALE) method passenger side airbags(PAB) airbag simulation sub-airbag tank test
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Research of the Gas-solid Flow Character Based on the DEM Method 被引量:2
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作者 Xueyao Wang and Yunhan Xiao Research Center for Clean Energy and Power,Chinese Academy of Sciences Key Laboratory of Advanced Energy and Power,Chinese Academy of Sciences (Institute of Engineering Thermophysics),Beijing,100190,China 《Journal of Thermal Science》 SCIE EI CAS CSCD 2011年第6期521-526,共6页
Numerical simulation of gas-solid flow behaviors in a rectangular fluidized bed is carried out three dimensionally by the discrete element method (DEM).Euler method and Lagrange method are employed to deal with the ga... Numerical simulation of gas-solid flow behaviors in a rectangular fluidized bed is carried out three dimensionally by the discrete element method (DEM).Euler method and Lagrange method are employed to deal with the gas phase and solid phase respectively.The collided force among particles,striking force between particle and wall,drag force,gravity,Magnus lift force and Saffman lift force are considered when establishing the mathematic models.Soft-sphere model is used to describe the collision of particles.In addition,the Euler method is also used for modeling the solid phase to compare with the results of DEM.The flow patterns,particle mean velocities,particles' diffusion and pressure drop of the bed under typical operating conditions are obtained.The results show that the DEM method can describe the detailed information among particles,while the Euler-Euler method cannot capture the micro-scale character.No matter which method is used,the diffusion of particles increases with the increase of gas velocity.But the gathering and crushing of particles cannot be simulated,so the energy loss of particles' collision cannot be calculated and the diffusion by using the Euler-Euler method is larger.In addition,it is shown by DEM method,with strengthening of the carrying capacity,more and more particles can be schlepped upward and the dense suspension upflow pattern can be formed.However,the results given by the Euler-Euler method are not consistent with the real situation. 展开更多
关键词 DEM gas-solid flow numerical simulation
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Transports of air particulate matters in the atmospheric boundary layer-numerical studies using Eulerian and Lagrangian methods 被引量:1
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作者 LU Hao WANG Bing +1 位作者 ZHANG HuiQiang WANG XiLin 《Science China Chemistry》 SCIE EI CAS 2013年第3期645-650,共6页
Transports of air particulate matters(PM) from face sources in the atmospheric boundary layer(ABL) are investigated by the Eulerian single fluid model and the Lagrangian trajectory method,respectively.Large eddy simul... Transports of air particulate matters(PM) from face sources in the atmospheric boundary layer(ABL) are investigated by the Eulerian single fluid model and the Lagrangian trajectory method,respectively.Large eddy simulation is used to simulate the fluid phase for high accuracy in both two approaches.The mean and fluctuating PM concentrations,as well as instantaneous PM distributions at different downstream and height positions,are presented.Higher mean and fluctuating particle concentrations are predicted by the Eulerian approach than the Lagrangian one.For the Lagrangian method,PM distributions cluster near the ground-wall because of the preferential dispersion of inertial particles by turbulence structures in the ABL,while it cannot be obtained by the Eulerian single fluid method,because the two-phase velocity differences are neglected in the Eulerian method. 展开更多
关键词 air pollution atmosphere boundary layer large eddy simulation Eulerian method Lagrangian method
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A Penalty-Regularization-Operator Splitting Method for the Numerical Solution of a Scalar Eikonal Equation
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作者 Alexandre CABOUSSAT Roland GLOWINSKI 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2015年第5期659-688,共30页
In this article, we discuss a numerical method for the computation of the minimal and maximal solutions of a steady scalar Eikonal equation. This method relies on a penalty treatment of the nonlinearity, a biharmonic ... In this article, we discuss a numerical method for the computation of the minimal and maximal solutions of a steady scalar Eikonal equation. This method relies on a penalty treatment of the nonlinearity, a biharmonic regularization of the resulting variational problem, and the time discretization by operator-splitting of an initial value problem associated with the Euler-Lagrange equations of the regularized variational problem. A low-order finite element discretization is advocated since it is well-suited to the low regularity of the solutions. Numerical experiments show that the method sketched above can capture efficiently the extremal solutions of various two-dimensional test problems and that it has also the ability of handling easily domains with curved boundaries. 展开更多
关键词 Eikonal equation Minimal and maximal solutions Regularization methods Penalization of equality constraints Dynamical flow Operator splitting Finite element methods
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A fractional-order model of HIV infection: Numerical solution and comparisons with data of patients
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作者 A. A. M. Arafa S. Z. Rida M. Khalil 《International Journal of Biomathematics》 2014年第4期23-33,共11页
In this paper, a fractional-order model which describes the human immunodeficiency type-1 virus (HIV-1) infection is presented. Numerical solutions are obtained using a generalized Euler method (GEM) to handle the... In this paper, a fractional-order model which describes the human immunodeficiency type-1 virus (HIV-1) infection is presented. Numerical solutions are obtained using a generalized Euler method (GEM) to handle the fractional derivatives. The fractional derivatives are described in the Caputo sense. We show that the model established in this paper possesses non-negative solutions. Comparisons between the results of the fractional-order model, the results of the integer model and the measured real data obtained from 10 patients during primary HIV-1 infection are presented. These compar- isons show that the results of the fractional-order model give predictions to the plasma virus load of the patients better than those of the integer model. 展开更多
关键词 Fractional calculus Euler method HIV model numerical results.
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