《伤寒论》中厥证辨证施治规律

《伤寒论》中论及手足厥冷之厥证的因机证治大略有热厥、寒厥、气郁致厥、血虚致厥、血虚寒凝致厥、痰(食)致厥、水厥、蛔厥、冷结膀胱关元致厥、脏厥、正伤邪陷,阳郁致厥等。其病因虽各不相同,但阴阳之气失去相对平衡,不能相互贯通的病理机制则为一致。其治疗应根据气血阴阳偏盛偏衰及寒热虚实等属性之不同,而分别采取吐,下、和(疏)、温、清、消(驱蛔)、补等法治之。

百脉根愈伤组织诱导研究

以MS为基本培养基,利用正交试验设计,研究了外植体类型、外源激素及其浓度配比对百脉根愈伤组织诱导的影响。结果表明:外植体类型和外源激素对百脉根愈伤组织诱导和褐化的影响均达到极显著水平(P<0.01),其中2,4-D浓度是影响百脉根愈伤组织诱导的主要因子,而NAA浓度是次要因子,以下胚轴为最佳外植体,添加1.0~2.0mg/L 2,4-D、0.5mg/L KT、0.5mg/L 6-BA进行愈伤组织培养效果最佳,诱导率可达100%。

仲景已病防变思想在临床中的运用举隅

结合《伤寒论》、《金匮要略》原文,介绍将仲景已病防变思想运用于中医内科临床决策,提高临床疗效的几个具体病例。

血栓性疾病的中医共性病机探讨

血栓性疾病现已成为我国及全球的重大健康问题,中医药具有一定防治优势。把握病机是中医诊疗的特点,全面、深化的梳理、诠释血栓性疾病发生、演变的中医共性规律,更有利于指导疾病的中医诊疗与科研。气机气化失常,痰湿、瘀血互结、互化,是血栓性疾病的发病基础;久积成毒是疾病转归和恶化的关键;火邪、风邪是不稳定因素,是急性血栓事件的直接动力;形气神受损、被扰,气血、脉络不通,是必然结果。

Gene expression arrays as a tool to unravel mechanisms of normal tissue radiation injury and prediction of response

Over the past 5 years there has been a rapid increase in the use of microarray technology in the field of cancer research, The majority of studies use microarray analysis of tumor biopsies for profiling of molecular characteristics in an attempt to produce robust classifiers for prognosis. There are now several published gene sets that have been shown to predict for aggressive forms of breast cancer, where patients are most likely to benefit from adjuvant chemotherapy and tumors most likely to develop distant metastases, or be resistant to treatment. The number of publications relating to the use of microarrays for analysis of normal tissue damage, after cancer treatment or genotoxic exposure, is much more limited. A PublVled literature search was conducted using the following keywords and combination of terms： radiation, normal tissue, microarray, gene expression profiling, prediction. With respect to normal tissue radiation injury, microarrays have been used in three ways： （1） to generate gene signatures to identify sensitive and resistant populations （prognosis）; （2） to identify sets of biomarker genes for estimating radiation exposure, either accidental or as a result of terrorist attack （diagnosis）; （3） to identify genes and pathways involved in tissue response to injury （mechanistic）. In this article we will review all （relevant） papers that covered our literature search criteria on microarray technology as it has been applied to normal tissue radiation biology and discuss how successful this has been in defining predisposition markers for radiation sensitivity or how it has helped us to unravel molecular mechanisms leading to acute and late tissue toxicity. We also discuss some of the problems and limitations in application and interpretation of such data.

Damage evolution analysis of cast steel GS-20Mn5V based on modified GTN model

A modified Gurson-Tvergaard-Needleman （GTN） model that accounts for the mixed （isotropic and kinematic） hardening of cast steel GS-20Mn5V was developed and implemented in the finite dement program ABAQUS/Standard via a user-defined material subroutine UMAT. This model couples the stress state and damage evolution （pore volume fraction increase） by a classic method that assumes that the total void volume fraction is divided into a nucleation and a growth part. A parametric study was conducted to assess the effect of modified GTN model parameters on mechanical properties such as the nucleation, growth and coalescence of voids and to obtain the optimal parameter combination by the orthogonal test method. The predicted load-displacement curves of notched specimens with the optimal parameters are favorably compared to the experimental curves. Therefore, the modified GTN model can be used to predict the damage evaluation and fracture behavior of GS-20Mn5V.

Dynamic Detection of Reinforced Concrete Bridge Damage by Finite Element Model Updating

The present work consists of dynamic detection of damages in reinforced concrete bridges by using a MMUM （mathematical model updating method） from incomplete test data. A well suited finite element model of a repaired bridge is carried out. The diagnosis enables us to locate and detect the damage in a reinforced concrete bridge. Thus, developments of analytical predictions have been checked by modal testing techniques. Besides, the FTCS （finite time centered space） scheme is developed to solve the set of equations which can easily handle finite element matrices of a bridge model. It is shown in this study that the method is applied to detect damages as well as existing cracks in real time of a repaired bridge. To check the efficiency of the method, the repaired bridge of OuedOumazer in Algeria has been selected. It is proven that identification methods have been able to detect the exact location of damage areas to be corrected avoiding the inaccuracy from the finite element model for the mass, stiffness and loading.

Discussion on the theory of paying equal attention to sinew and bone in China osteosynthesis

‘Paying equal attention to sinew and bone＇ is an important principle in China osteosynthesis （CO）. Traditional bone-setting manipulations not only pay high attention to fracture reduction, but also to sinew-regulating and soft tissues protection. The advantage of this principle has also been confirmed by modern medicine. To understand the principle better, it is essential to learn its historical origin, its important role in traumatology and its significant influence on modern orthopedics. In addition, we should inherit and further develop its theory, innovate and promote the development of CO constantly.

Structural behaviour of fibre metal laminates subjected to a low velocity impact

Structural impact tests were first presented to cover typical fibre metal laminates (FMLs) subjected a low velocity projectile impact,which produced the corresponding load-displacement traces and deformation/failure modes for the validation of numerical models.Finite element (FE) models were then developed to simulate the impact behaviour of FMLs tested.The aluminium (alloy grade 2024-0) layer was modelled as an isotropic elasto-plastic material up to the on-set of post failure stage,followed by shear failure and tensile failure to simulate its failure mechanisms.The glass fibre laminate (woven glass-fibre reinforced composite) layer was modelled as an orthotropic material up to its on-set of damage,followed by damage initiation and evolution using the Hashin criterion.The damage initiation was controlled by failure tensile and compressive stresses within the lamina plane which were primarily determined by tests.The damage evolution was controlled by tensile/compressive fracture energies combined with both fibre and matrix.The FE models developed for the 2/1,3/2 and 4/3 FMLs plates made with 4-ply and 8-ply glass fibre laminate cores were validated against the corresponding experimental results.Good correlation was obtained in terms of load-displacement traces,deformation and failure modes.The validated models were ready to be used to undertake parametric studies to cover FMLs plates made with various stack sequences and composite cores.