期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
肿瘤干细胞发生机制的研究现状 被引量:1
1
作者 何明生 郭涛 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2007年第28期5618-5621,共4页
目的:肿瘤干细胞的产生机制对于理解肿瘤的生物学行为及研究治疗对策具有重要意义,文章就肿瘤干细胞及其生长机制作一综述。资料来源:应用计算机检索PUBMED2001-01/2006-12期间的相关文章,检索词为“tumor stem cell,the mechanism of g... 目的:肿瘤干细胞的产生机制对于理解肿瘤的生物学行为及研究治疗对策具有重要意义,文章就肿瘤干细胞及其生长机制作一综述。资料来源:应用计算机检索PUBMED2001-01/2006-12期间的相关文章,检索词为“tumor stem cell,the mechanism of generation of tumor stem cells”,并限定文章语言种类为English。同时计算机检索中国期刊全文数据库2001-01/2006-12期间的相关文章,检索词为“肿瘤干细胞,肿瘤干细胞生长机制”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:①需为非综述性、非个案报道类的文献。②肿瘤干细胞及其生长机制文章。排除标准:重复研究、个案报道、综述、Meta分析类的文献。资料提炼:共收集到144篇相关文献,37篇文献符合纳入标准,排除的107篇文献为内容陈旧或重复。符合纳入标准的37篇文献中,分别涉及正常干细胞与肿瘤干细胞的关系、肿瘤干细胞的产生机制以及研究肿瘤干细胞的意义。资料综合:肿瘤干细胞是存在于肿瘤中的一小群具有干细胞性质的癌细胞亚群,可自我更新及分化,是形成不同分化程度的肿瘤细胞与肿瘤不断扩大的根源。肿瘤干细胞与正常干细胞有许多相同的标记物,一定条件下可以互相转化,且大量实验成果证明一些参与正常干细胞自我更新的基因和信号传导机制同样参与肿瘤的发生。正常干细胞可以迁移到特异的组织和器官,而这可以解释肿瘤转移也有一定器官和组织特异性。肿瘤干细胞的产生机制对于理解肿瘤的生物学行为及研究治疗对策有重要意义,目前各种肿瘤干细胞生长机制学说如干细胞起源学说、基因突变学说、非整倍体学说、融合细胞学说及端粒酶的影响均不能完整阐述其生长机制,还有待于进一步研究。结论:了解肿瘤干细胞的多种生物学行为及生长机制,将直接有利于肿瘤的治疗。 展开更多
关键词 肿瘤干细胞 正常干细胞 生长机制 综述文献
下载PDF
ALDH1作为干细胞标记物的研究进展 被引量:15
2
作者 韩明利 吴诚义 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2010年第5期1183-1186,共4页
乙醛脱氢酶1(ALDH1、ALDH1A1或RALDH1)是催化细胞内乙醛氧化为乙酸的细胞溶质酶,也是正常干细胞与肿瘤干细胞(CSC)的通用标记物之一,在多种组织中起重要作用。主要就近年来有关ALDH1作为干细胞标记物的研究进展包括其与正常干细胞、CSC... 乙醛脱氢酶1(ALDH1、ALDH1A1或RALDH1)是催化细胞内乙醛氧化为乙酸的细胞溶质酶,也是正常干细胞与肿瘤干细胞(CSC)的通用标记物之一,在多种组织中起重要作用。主要就近年来有关ALDH1作为干细胞标记物的研究进展包括其与正常干细胞、CSC(特别是乳腺癌干细胞)的关系以及ALDH1+干细胞的鉴定和分离等方面作一综述。 展开更多
关键词 乙醛脱氢酶1 干细胞 正常干细胞 肿瘤干细胞 通用标记物
原文传递
Comparison of biological characteristics of marrow mesenchymal stem cells in hepatitis B patients and normal adults 被引量:9
3
作者 Liang Peng Hua Li Lin Gu Xiao-Mou Peng Yang-Su Huang Zhi-Liang Gao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第11期1743-1746,共4页
AIM: To establish a culture system of marrow mesenchymal stem cells (MSCs)from hepatitis B patients and normal adults and to compare their biological characteristics. METHODS: MSCs were isolated from bone marrow in 34... AIM: To establish a culture system of marrow mesenchymal stem cells (MSCs)from hepatitis B patients and normal adults and to compare their biological characteristics. METHODS: MSCs were isolated from bone marrow in 34 male hepatitis B patients and 15 male normal adults and cultivated in vitro. Their biological characteristics including surface markers, shapes and appearances, growth curves, first passage time and passage generations were compared. RESULTS: Cultivation achievement ratio of hepatitis B patients was lower than that of normal adults, no statistical significance (82.35% vs 100%, P > 0.05). Compared with MSCs of normal adults, MSCs of hepatitis B patients presented a statistical lower growth curve, longer first passage time (13.0 ± 1.6 d vs 11.4 ± 1.5 d, P < 0.05), fewer passaging generation numbers (10.5 ± 1.4 generations vs 12.3 ± 1.7 generations, P < 0.05), though both shared same appearances, shapes and surface markers. MSCs in hepatitis B patients would expand, spread out and age more easily and there were more refractive particles in the cytoplasm. CONCLUSION: MSCs from hepatitis B patients can be cultured in vitro. Although their appearance, shape and surface marker are similar to those of MSCs from normal adults, there are differences in their biological characteristics. 展开更多
关键词 Marrow mesenchymal stem cells Culture in vitro Biological characters
下载PDF
CD133 and membrane microdomains:Old facets for future hypotheses 被引量:1
4
作者 Christine A Fargeas Jana Karbanová +1 位作者 József Jászai Denis Corbeil 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第36期4149-4152,共4页
Understanding all facets of membrane microdomains in normal and cancerous cells within the digestive tract is highly important,not only from a clinical point of view,but also in terms of our basic knowledge of cellula... Understanding all facets of membrane microdomains in normal and cancerous cells within the digestive tract is highly important,not only from a clinical point of view,but also in terms of our basic knowledge of cellular transformation.By studying the normal and cancer stem cell-associated molecule CD133 (prominin-1),novel aspects of the organization and dynamics of polarized epithelial cells have been revealed during the last decade.Its association with particular membrane microdomains is highly relevant in these contexts and might also offer new avenues in diagnosis and/or targeting of cancer stem cells. 展开更多
关键词 AC133 Cancer CD133 Membrane microdomains Membrane vesicles Prominin-1 Stem cell
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部