Purpose:To measure the oxygen saturation(SO2)in retinal arterioles and venules in patients with glaucomatous optic neuropathy.Methods:We examined SO2 in retinal arterioles and venules simultaneously by imaging spectro...Purpose:To measure the oxygen saturation(SO2)in retinal arterioles and venules in patients with glaucomatous optic neuropathy.Methods:We examined SO2 in retinal arterioles and venules simultaneously by imaging spectrometry.Oxygen saturationwas evaluated according to the difference of the extinction spectra of haemoglobin and oxyhaemog-lobin.The arterio-venous difference(avD)was calculated by(SO2art-SO2ven).The optic nerve head topography was estimated by Heidelberg retinal tomography and the visual field using the Octopus G1.We examined one eye in each of 58 healthy persons(mean age 58.6 ± 10.7 years;mean rim area 1.52± 0.33mm2;mean defect 0.65± 1.31 dB;mean intraocular pressure IOP 18.5± 2.7 mmHg),49 patients with normal-tension primary open-angle glaucoma(NTG)(mean age 63.0± 8.5 years;mean rim area 0.89± 0.34 mm2;mean defect 5.4± 4.1dB;mean IOP 19.2± 2.9 mmHg),and 45 patients with high-tension primary open-angle glaucoma(POAG)(mean age 62.6± 10.3 years;mean rim area 0.97± 0.47 mm2;mean defect 7.1± 6.4 dB;mean IOP 31.6± 10.8 mmHg).Results:The intraclass correlation coefficients of the SO2 measurement were 0.82(arteriole)and 0.59(venule).In normal eyes,the SO2art,SO2ven and avD were 92.3± 3.4%,55.7 ± 6.8% and 36.6± 7.0%,respectively.Equivalent data were 89.7± 5.4%,56.0± 8.3% and 33.7± 10.6%,respectively,in NTG eyes and 91.4± 4.0%,58.3± 10.5% and 33.1± 11.5%,respectively,in POAG eyes.Over all examined eyes,the arteriolar SO2 and the retinal arterio-venous difference correlated significantly with the rim area.Conclusion:Eyes with NTG showed significantly decreased arteriolar SO2.These changes were not seen in POAG patients.展开更多
Background: To investigate the effects of oral nimodipine on ocular hemodynamic parameters and color contrast sensitivity in patients with normal tension glaucoma (NTG). Methods: The study was performed in 14 consecut...Background: To investigate the effects of oral nimodipine on ocular hemodynamic parameters and color contrast sensitivity in patients with normal tension glaucoma (NTG). Methods: The study was performed in 14 consecutive NTG patients in a randomized placebo controlled double-masked cross-over design. The effects or oral nimodipine (60 mg) or placebo on ocular and systemic hemodynamic parameters and color contrast展开更多
文摘Purpose:To measure the oxygen saturation(SO2)in retinal arterioles and venules in patients with glaucomatous optic neuropathy.Methods:We examined SO2 in retinal arterioles and venules simultaneously by imaging spectrometry.Oxygen saturationwas evaluated according to the difference of the extinction spectra of haemoglobin and oxyhaemog-lobin.The arterio-venous difference(avD)was calculated by(SO2art-SO2ven).The optic nerve head topography was estimated by Heidelberg retinal tomography and the visual field using the Octopus G1.We examined one eye in each of 58 healthy persons(mean age 58.6 ± 10.7 years;mean rim area 1.52± 0.33mm2;mean defect 0.65± 1.31 dB;mean intraocular pressure IOP 18.5± 2.7 mmHg),49 patients with normal-tension primary open-angle glaucoma(NTG)(mean age 63.0± 8.5 years;mean rim area 0.89± 0.34 mm2;mean defect 5.4± 4.1dB;mean IOP 19.2± 2.9 mmHg),and 45 patients with high-tension primary open-angle glaucoma(POAG)(mean age 62.6± 10.3 years;mean rim area 0.97± 0.47 mm2;mean defect 7.1± 6.4 dB;mean IOP 31.6± 10.8 mmHg).Results:The intraclass correlation coefficients of the SO2 measurement were 0.82(arteriole)and 0.59(venule).In normal eyes,the SO2art,SO2ven and avD were 92.3± 3.4%,55.7 ± 6.8% and 36.6± 7.0%,respectively.Equivalent data were 89.7± 5.4%,56.0± 8.3% and 33.7± 10.6%,respectively,in NTG eyes and 91.4± 4.0%,58.3± 10.5% and 33.1± 11.5%,respectively,in POAG eyes.Over all examined eyes,the arteriolar SO2 and the retinal arterio-venous difference correlated significantly with the rim area.Conclusion:Eyes with NTG showed significantly decreased arteriolar SO2.These changes were not seen in POAG patients.
文摘Background: To investigate the effects of oral nimodipine on ocular hemodynamic parameters and color contrast sensitivity in patients with normal tension glaucoma (NTG). Methods: The study was performed in 14 consecutive NTG patients in a randomized placebo controlled double-masked cross-over design. The effects or oral nimodipine (60 mg) or placebo on ocular and systemic hemodynamic parameters and color contrast
