PURPOSE: Serum carcinoembryonic antigen elevation without detectable relapse during colorectal cancer follow-up presents a challenge. This study was designed to evaluate the utility of fluorine-18-labeled 2-fluoro-2-d...PURPOSE: Serum carcinoembryonic antigen elevation without detectable relapse during colorectal cancer follow-up presents a challenge. This study was designed to evaluate the utility of fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography in colorectal cancer patients with unexplained carcinoembryonic antigen elevation at different levels. METHODS: Thirty-seven colorectal cancer patients referred for positron emission tomography after primary surgery who had serum carcinoembryonic antigen levels >5 ng/ml and negative or equivocal conventional imaging studies were analyzed. Patient status was determined by histopathology and/or clinical followup. Grouping as disease-free, potentially resectable, or advanced disease was performed. The management impact was defined as the percentage of patients with a true-positive positron emission tomography result. RESULTS: The sensitivity, specificity, and accuracy of positron emission tomography for relapse detection were 89, 89, and 89 percent, respectively. The management impact was 68 percent. In 24 patients with carcinoembryonic antigen levels < 25 ng/ml, positron emission tomography helped correct patient grouping in 20 patients (83 percent), including 8 in the disease-free group, 5 in the potentially resectable group, and 7 in the advanced-disease group. In 13 patients with carcinoembryonic antigen levels > 25 ng/ml, positron emission tomography identified 8 patients in the advanced-disease group and 1 patient in the potentially resectable group but missed 2 patients with relapse and undergrouped 2 patients in the advanced-disease group as potentially resectable. CONCLUSIONS: 2-flu-oro-2-deoxy-D-glucose positron emission tomography can help triage patients for appropriate management with unexplained carcinoembryonic antigen elevation < 25 ng/ml. For patients with unexplained elevation of carcinoembryonic antigen >25 ng/ml, the utility of positron emission tomography is mainly to confirm the presence of advanced disease and occasionally to identify potentially resectable lesions.展开更多
目的:探讨256层螺旋计算机断层摄影术(CT)测定的心外膜脂肪组织体积(EATV)与心房颤动(房颤)的相关性。方法:选择2016-09至2017-09我院收治的房颤患者66例作为房颤组,其中阵发性房颤患者42例,持续性房颤患者24例;同期入选70例窦性心律者...目的:探讨256层螺旋计算机断层摄影术(CT)测定的心外膜脂肪组织体积(EATV)与心房颤动(房颤)的相关性。方法:选择2016-09至2017-09我院收治的房颤患者66例作为房颤组,其中阵发性房颤患者42例,持续性房颤患者24例;同期入选70例窦性心律者作为窦性心律组。136例患者均行256层螺旋CT心脏成像,测量所有患者的EATV、房颤组患者的心周脂肪组织体积(PATV)。进一步对阵发性房颤患者与持续性房颤患者的EATV等进行统计分析。结果:房颤组患者的EATV大于窦性心率组[(138.94±37.93)ml vs(93.55±34.79)ml,P<0.001]。持续性房颤患者的EATV[(142.20±40.86)ml vs (137.07±36.53)ml]、PATV[(230.67±60.83)mlvs(223.56±60.62)ml]均高于阵发性房颤患者,但差异均无统计学意义(P>0.05)。房颤患者的EATV与PATV呈显著正相关(r=0.953,P<0.001)。多因素Logistic回归分析结果显示,EATV是房颤发生的独立相关危险因素(OR=1.143,95%CI:1.027~1.158),P=0.000)。结论:采用256层螺旋CT可以客观定量测量EATV,EATV与PATV显著相关,EATV的增加与房颤的发生密切相关,但不同类型房颤患者之间的EATV差异不显著。展开更多
文摘PURPOSE: Serum carcinoembryonic antigen elevation without detectable relapse during colorectal cancer follow-up presents a challenge. This study was designed to evaluate the utility of fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography in colorectal cancer patients with unexplained carcinoembryonic antigen elevation at different levels. METHODS: Thirty-seven colorectal cancer patients referred for positron emission tomography after primary surgery who had serum carcinoembryonic antigen levels >5 ng/ml and negative or equivocal conventional imaging studies were analyzed. Patient status was determined by histopathology and/or clinical followup. Grouping as disease-free, potentially resectable, or advanced disease was performed. The management impact was defined as the percentage of patients with a true-positive positron emission tomography result. RESULTS: The sensitivity, specificity, and accuracy of positron emission tomography for relapse detection were 89, 89, and 89 percent, respectively. The management impact was 68 percent. In 24 patients with carcinoembryonic antigen levels < 25 ng/ml, positron emission tomography helped correct patient grouping in 20 patients (83 percent), including 8 in the disease-free group, 5 in the potentially resectable group, and 7 in the advanced-disease group. In 13 patients with carcinoembryonic antigen levels > 25 ng/ml, positron emission tomography identified 8 patients in the advanced-disease group and 1 patient in the potentially resectable group but missed 2 patients with relapse and undergrouped 2 patients in the advanced-disease group as potentially resectable. CONCLUSIONS: 2-flu-oro-2-deoxy-D-glucose positron emission tomography can help triage patients for appropriate management with unexplained carcinoembryonic antigen elevation < 25 ng/ml. For patients with unexplained elevation of carcinoembryonic antigen >25 ng/ml, the utility of positron emission tomography is mainly to confirm the presence of advanced disease and occasionally to identify potentially resectable lesions.
文摘目的:探讨256层螺旋计算机断层摄影术(CT)测定的心外膜脂肪组织体积(EATV)与心房颤动(房颤)的相关性。方法:选择2016-09至2017-09我院收治的房颤患者66例作为房颤组,其中阵发性房颤患者42例,持续性房颤患者24例;同期入选70例窦性心律者作为窦性心律组。136例患者均行256层螺旋CT心脏成像,测量所有患者的EATV、房颤组患者的心周脂肪组织体积(PATV)。进一步对阵发性房颤患者与持续性房颤患者的EATV等进行统计分析。结果:房颤组患者的EATV大于窦性心率组[(138.94±37.93)ml vs(93.55±34.79)ml,P<0.001]。持续性房颤患者的EATV[(142.20±40.86)ml vs (137.07±36.53)ml]、PATV[(230.67±60.83)mlvs(223.56±60.62)ml]均高于阵发性房颤患者,但差异均无统计学意义(P>0.05)。房颤患者的EATV与PATV呈显著正相关(r=0.953,P<0.001)。多因素Logistic回归分析结果显示,EATV是房颤发生的独立相关危险因素(OR=1.143,95%CI:1.027~1.158),P=0.000)。结论:采用256层螺旋CT可以客观定量测量EATV,EATV与PATV显著相关,EATV的增加与房颤的发生密切相关,但不同类型房颤患者之间的EATV差异不显著。