A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes toα,β‐unsaturated‐γ‐lactams via a cyclic N‐acyliminium ion intermediate. This simple reaction pro‐ceeds rapidly u...A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes toα,β‐unsaturated‐γ‐lactams via a cyclic N‐acyliminium ion intermediate. This simple reaction pro‐ceeds rapidly under mild conditions, and provided a practical approach for the synthesis of a wide range of 5‐alkynyl‐2‐pyrrolidinones in moderate to good yields （45%–76%）.展开更多
The Lancang–Mekong River basin(LMRB) is under increasing threat from global warming. In this paper, the projection of future climate in the LMRB is explored by focusing on the temperature change and extreme temperatu...The Lancang–Mekong River basin(LMRB) is under increasing threat from global warming. In this paper, the projection of future climate in the LMRB is explored by focusing on the temperature change and extreme temperature events. First, the authors evaluate the bias of temperature simulated by the Weather Research and Forecasting model. Then, correction is made for the simulation by comparing with observation based on the non-parametric quantile mapping using robust empirical quantiles(RQUANT) method. Furthermore, using the corrected model results, the future climate projections of temperature and extreme temperature events in this basin during 2016–35, 2046–65, and 2080–99 are analyzed. The study shows that RQUANT can effectively reduce the bias of simulation results. After correction, the simulation can capture the spatial features and trends of mean temperature over the LMRB, as well as the extreme temperature events. Besides, it can reproduce the spatial and temporal distributions of the major modes. In the future, the temperature will keep increasing, and the warming in the southern basin will be more intense in the wet season than the dry season. The number of extreme high-temperature days exhibits an increasing trend, while the number of extreme low-temperature days shows a decreasing trend. Based on empirical orthogonal function analysis, the dominant feature of temperature over this basin shows a consistent change. The second mode shows a seesaw pattern.展开更多
The mechanical behaviors near the interface crack tip for mode Ⅰ of orthotropic bimaterial are researched. With the help of the complex function method and the undetermined coefficient method, non-oscillatory field i...The mechanical behaviors near the interface crack tip for mode Ⅰ of orthotropic bimaterial are researched. With the help of the complex function method and the undetermined coefficient method, non-oscillatory field if the singularity exponent is a real number, and oscillatory field if the singularity exponent is a complex number are discussed, respectively. For each case, the stress functions are constructed which contain twelve undetermined coefficients and an unknown singularity exponent. Based on the boundary conditions, the system of non-homogeneous linear equations is obtained. According to the necessary and sufficient condition for the existence of solution for the system of non-homogeneous linear equations, the singularity exponent is determined under appropriate condition using bimaterial parameters. Both the theoretical formulae of stress intensity factors and analytic solutions of stress or displacement field near the interface crack tip are given. When the two orthotropic materials are the same, the classical results for orthotropic single material are deduced.展开更多
The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked s...The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.展开更多
The output characteristics of neodymium-doped gadolinium vanadate(Nd:GdVO4) crystals laser with dual c-axis orthogonal gains end-pumped by two fiber-coupled diode lasers are investigated. With two 1 W semiconductor di...The output characteristics of neodymium-doped gadolinium vanadate(Nd:GdVO4) crystals laser with dual c-axis orthogonal gains end-pumped by two fiber-coupled diode lasers are investigated. With two 1 W semiconductor diode lasers pumping, the output power of TEM00 laser is 920 m W, and the optical conversion efficiency is close to 46%. By changing the relative orientations of both Nd:Gd VO4 crystals, the polarization characteristics of laser are varied. In particular, by keeping the c-axes of two Nd:Gd VO4 crystals orthogonal to each other and adjusting two diode pump lasers to operate at the same power level, the completely unpolarized light is obtained.展开更多
基金supported by the National Natural Science Foundation of China(21222203,21172226,21133011)
文摘A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes toα,β‐unsaturated‐γ‐lactams via a cyclic N‐acyliminium ion intermediate. This simple reaction pro‐ceeds rapidly under mild conditions, and provided a practical approach for the synthesis of a wide range of 5‐alkynyl‐2‐pyrrolidinones in moderate to good yields （45%–76%）.
基金This work was supported by the External Cooperation Program of Bureau of International Co-operation,Chinese Academy of Sciences[grant number GJHZ1729]the Key Program of the Natural Science Foundation of Yunnan Province of China[grant number 2016FA041].
文摘The Lancang–Mekong River basin(LMRB) is under increasing threat from global warming. In this paper, the projection of future climate in the LMRB is explored by focusing on the temperature change and extreme temperature events. First, the authors evaluate the bias of temperature simulated by the Weather Research and Forecasting model. Then, correction is made for the simulation by comparing with observation based on the non-parametric quantile mapping using robust empirical quantiles(RQUANT) method. Furthermore, using the corrected model results, the future climate projections of temperature and extreme temperature events in this basin during 2016–35, 2046–65, and 2080–99 are analyzed. The study shows that RQUANT can effectively reduce the bias of simulation results. After correction, the simulation can capture the spatial features and trends of mean temperature over the LMRB, as well as the extreme temperature events. Besides, it can reproduce the spatial and temporal distributions of the major modes. In the future, the temperature will keep increasing, and the warming in the southern basin will be more intense in the wet season than the dry season. The number of extreme high-temperature days exhibits an increasing trend, while the number of extreme low-temperature days shows a decreasing trend. Based on empirical orthogonal function analysis, the dominant feature of temperature over this basin shows a consistent change. The second mode shows a seesaw pattern.
基金supported by the Natural Science Foundation of Shanxi Province (Grant No. 2011011021-3)
文摘The mechanical behaviors near the interface crack tip for mode Ⅰ of orthotropic bimaterial are researched. With the help of the complex function method and the undetermined coefficient method, non-oscillatory field if the singularity exponent is a real number, and oscillatory field if the singularity exponent is a complex number are discussed, respectively. For each case, the stress functions are constructed which contain twelve undetermined coefficients and an unknown singularity exponent. Based on the boundary conditions, the system of non-homogeneous linear equations is obtained. According to the necessary and sufficient condition for the existence of solution for the system of non-homogeneous linear equations, the singularity exponent is determined under appropriate condition using bimaterial parameters. Both the theoretical formulae of stress intensity factors and analytic solutions of stress or displacement field near the interface crack tip are given. When the two orthotropic materials are the same, the classical results for orthotropic single material are deduced.
基金supported by the National Natural Science Foundation of China (21505010, 21173274)Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcyj A1357)Scientific Research Innovation Team of Chongqing University of Technology (2015TD22)
文摘The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.
基金supported by the National Natural Science Foundation of China(No.11104234)
文摘The output characteristics of neodymium-doped gadolinium vanadate(Nd:GdVO4) crystals laser with dual c-axis orthogonal gains end-pumped by two fiber-coupled diode lasers are investigated. With two 1 W semiconductor diode lasers pumping, the output power of TEM00 laser is 920 m W, and the optical conversion efficiency is close to 46%. By changing the relative orientations of both Nd:Gd VO4 crystals, the polarization characteristics of laser are varied. In particular, by keeping the c-axes of two Nd:Gd VO4 crystals orthogonal to each other and adjusting two diode pump lasers to operate at the same power level, the completely unpolarized light is obtained.
