1 Introduction Environmental factors such as maternal nutrition during intrauterine development may program the neuroendocrine system and alter its function in later life （Cerf et al., 2012）. It is demonstrated tha...1 Introduction Environmental factors such as maternal nutrition during intrauterine development may program the neuroendocrine system and alter its function in later life （Cerf et al., 2012）. It is demonstrated that meta- bolic diseases have their origin in early life nutritional experience such as maternal high-fat （HF） diet con- sumption during gestation and lactation （Srinivasan et al., 2006）. The changes in energy balance and cells＇ response to insulin are the important metabolic changes in the offspring of HF-fed dams （Sullivan et al., 2015）. Maternal HF diet consumption increased abdominal fat in dams at the end of the lactation pe- riod with increased （Jacobs et al., 2014） or without any change （Desai et al., 2014） in leptin plasma level.展开更多
基金Project supported by the Grant from the Research Deputy of Faculty of Medicine,Shahid Beheshti University of Medical Sciences(No.13/542),Iran
文摘1 Introduction Environmental factors such as maternal nutrition during intrauterine development may program the neuroendocrine system and alter its function in later life （Cerf et al., 2012）. It is demonstrated that meta- bolic diseases have their origin in early life nutritional experience such as maternal high-fat （HF） diet con- sumption during gestation and lactation （Srinivasan et al., 2006）. The changes in energy balance and cells＇ response to insulin are the important metabolic changes in the offspring of HF-fed dams （Sullivan et al., 2015）. Maternal HF diet consumption increased abdominal fat in dams at the end of the lactation pe- riod with increased （Jacobs et al., 2014） or without any change （Desai et al., 2014） in leptin plasma level.
