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病原体毒性进化多样性的动力学模型
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作者 原博 《生物化工》 2019年第5期30-33,共4页
传染病一直以来都是危害人类健康的最大劲敌,并且越来越多病原体的毒性表现出了多样性的特点;基于适应动力学等方法去研究病原体的毒性进化,可以为传染病治疗方法的设计和防控策略的制定提供一些定量参考和有效的建议。本文主要从典型... 传染病一直以来都是危害人类健康的最大劲敌,并且越来越多病原体的毒性表现出了多样性的特点;基于适应动力学等方法去研究病原体的毒性进化,可以为传染病治疗方法的设计和防控策略的制定提供一些定量参考和有效的建议。本文主要从典型的传播动力学模型出发,利用动力系统理论和进化动力学理论等方法主要研究一类自然死亡率不具有种群密度依赖的SI模型,讨论了自然死亡率和出生率对进化稳定策略的影响。研究发现,此模型下只要进化奇异策略是收敛稳定的,也必定是进化稳定的,不会出现病原体毒力进化分支的现象。 展开更多
关键词 病原体 适应动力学 临界函数分析法 毒性进化 进化分支 进化动力学模型
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Genomic Sequencing and Molecular Characteristics of A Very Virulent Strain of Infectious Bursal Disease Virus Isolated in China 被引量:4
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作者 祁小乐 高立 +9 位作者 秦立廷 邓小芸 吴关 张礼洲 余飞 任宪刚 高玉龙 高宏雷 王永强 王笑梅 《Agricultural Science & Technology》 CAS 2011年第12期1946-1949,共4页
[Objective] The paper was to determine the genomic sequence of a very virulent strain of infectious bursal disease virus(IBDV),and study its molecular characteristics.[Method] A very virulent strain(vvIBDV)(HLJ-0... [Objective] The paper was to determine the genomic sequence of a very virulent strain of infectious bursal disease virus(IBDV),and study its molecular characteristics.[Method] A very virulent strain(vvIBDV)(HLJ-0504) of infectious bursal disease virus(IBDV) with special characters was isolated in China and its genome was sequenced.[Result] Sequence analysis showed that segment A of HLJ-0504 was derived from vvIBDV,while segment B was from a distinct ancestor.The morbidity and mortality of HLJ-0504 was 100% and 86.7%to SPF chickens,respectively.[Conclusion] vvIBDV with distinct segment B were still circulating and the evolution of IBDV was diversified in China.Besides,it is hard to imagine that the virulence of IBDV is determined solely by segment A or B. 展开更多
关键词 Infectious bursal disease virus(IBDV) GENOME EVOLUTION VIRULENCE
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Viral exploitation of actin: force-generation and scaffolding functions in viral infection 被引量:2
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作者 Mark Spear Yuntao Wu 《Virologica Sinica》 SCIE CAS CSCD 2014年第3期139-147,共9页
As a fundamental component of the host cellular cytoskeleton, actin is routinely engaged by infecting viruses. Furthermore, viruses from diverse groups, and infecting diverse hosts, have convergently evolved an array ... As a fundamental component of the host cellular cytoskeleton, actin is routinely engaged by infecting viruses. Furthermore, viruses from diverse groups, and infecting diverse hosts, have convergently evolved an array of mechanisms for manipulating the actin cytoskeleton for efficacious infection. An ongoing chorus of research now indicates that the actin cytoskeleton is critical for viral replication at many stages of the viral life cycle, including binding, entry, nuclear localization, genomic transcription and reverse transcription, assembly, and egress/dissemination. Specifically, viruses subvert the force-generating and macromolecular scaffolding properties of the actin cytoskeleton to propel viral surfing, internalization, and migration within the cell. Additionally, viruses utilize the actin cytoskeleton to support and organize assembly sites, and eject budding virions for cell-to-cell transmission. It is the purpose of this review to provide an overview of current research, focusing on the various mechanisms and themes of virus-mediated actin modulation described therein. 展开更多
关键词 viral infection actin cytoskeleton cofilin LIMK Arp2/3 GTPase
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