Narcolepsy is widely believed to have an autoimmune basis, but conventional i mmunological approaches have failed to detect a serum autoantibody marker. Since cholinergic hyperactivity is a feature of narcolepsy cat...Narcolepsy is widely believed to have an autoimmune basis, but conventional i mmunological approaches have failed to detect a serum autoantibody marker. Since cholinergic hyperactivity is a feature of narcolepsy cataplexy, we transferre d IgG from nine patients with narcolepsy and nine healthy controls to mice and a ssessed the effect on smooth muscle contractile responses to cholinergic stimula tion. IgG from all narcolepsy patients significantly enhanced bladder contractil e responses to the muscarinic agonist carbachol and to neuronally released acety lcholine compared with control IgG (p < 0 0001) , whereas contraction of the s ympathetically innervated vas deferens was unaltered. Our findings provide direc t evidence for the autoimmune hypothesis of narcolepsy.展开更多
文摘Narcolepsy is widely believed to have an autoimmune basis, but conventional i mmunological approaches have failed to detect a serum autoantibody marker. Since cholinergic hyperactivity is a feature of narcolepsy cataplexy, we transferre d IgG from nine patients with narcolepsy and nine healthy controls to mice and a ssessed the effect on smooth muscle contractile responses to cholinergic stimula tion. IgG from all narcolepsy patients significantly enhanced bladder contractil e responses to the muscarinic agonist carbachol and to neuronally released acety lcholine compared with control IgG (p < 0 0001) , whereas contraction of the s ympathetically innervated vas deferens was unaltered. Our findings provide direc t evidence for the autoimmune hypothesis of narcolepsy.
