To solve the excessive huge scale problem of the traditional multi-bit digital artificial neural network(ANN) hardware implementation methods,a bit-stream ANN hardware implementation method based on sigma delta(Σ...To solve the excessive huge scale problem of the traditional multi-bit digital artificial neural network(ANN) hardware implementation methods,a bit-stream ANN hardware implementation method based on sigma delta(ΣΔ) modulation is presented.The bit-stream adder,multiplier,threshold function unit and fully digital ΣΔ modulator are implemented in a field programmable gate array(FPGA),and these bit-stream arithmetical units are employed to build the bit-stream artificial neuron.The function of the bit-stream artificial neuron is verified through the realization of the logic function and a linear classifier.The bit-stream perceptron based on the bit-stream artificial neuron with the pre-processed structure is proved to have the ability of nonlinear classification.The FPGA resource utilization of the bit-stream artificial neuron shows that the bit-stream ANN hardware implementation method can significantly reduce the demand of the ANN hardware resources.展开更多
A new chaos control method is proposed to take advantage of chaos or avoid it. The hybrid Internal Model Control and Proportional Control learning scheme are introduced. In order to gain the desired robust performance...A new chaos control method is proposed to take advantage of chaos or avoid it. The hybrid Internal Model Control and Proportional Control learning scheme are introduced. In order to gain the desired robust performance and ensure the system's stability, Adaptive Momentum Algorithms are also developed. Through properly designing the neural network plant model and neural network controller, the chaotic dynamical systems are controlled while the parameters of the BP neural network are modified. Taking the Lorenz chaotic system as example, the results show that chaotic dynamical systems can be stabilized at the desired orbits by this control strategy.展开更多
Arguably, Africa comparatively remains a huge account for narratives within the context of repository of misery and violence in the 21 st-century, an attempt to political development has posed an irresistible challeng...Arguably, Africa comparatively remains a huge account for narratives within the context of repository of misery and violence in the 21 st-century, an attempt to political development has posed an irresistible challenge and a disturbing necessity for Mia Couto in Voices Made Night (1990) and Bessie Head in Tales of Tenderness and Power (1989). The position of Couto as a white Mozambican writer and Head as an exiled coloured South African writer, living in her adopted country of Botswana, provides them with privileged neutrality from which to view the effect of the admixture of grinding poverty and violence as they ravage the landscapes of these countries. While Couto does not fail to incorporate the significance of power struggle between FRELIMO (Front for the Liberation of Mozambique) and RENAMO (Mozambique National Resistance) in the ~'oices Made Night, Head's articulation of the complex manipulation of power becomes a resource for constructing a discourse of nationalism in Tales of Tenderness and Power. The paper intends to focus on the correlation between power and economic development in these anthologies. The paper will further examine how political power impacts on the socio-economic well being of the local folks in the Couto's Mozambique and Head's South Africa.展开更多
After athletes' intensive training and competition, they would suffer from fatigue. Therefore, the measures to recover their motor and nervous systems from the fatigue are very important. In this research, this autho...After athletes' intensive training and competition, they would suffer from fatigue. Therefore, the measures to recover their motor and nervous systems from the fatigue are very important. In this research, this author tries to investigate the methods to recover one' s joints and relax one' s nervous system, and detailed methods would also be provided for reference. Objective conditions, like sports fields and equipment, have become relatively satisfactory. There are high-level coaches and athletes who are carefully and scientifically chosen, so that good athletic performance is well guaranteed. To improve sports teams' comprehensive sports skills, we have to adopt and grasp some advanced training methods and skills. But after intensive training and fierce competition, athletes' motor and nervous system would suffer from fatigue, therefore, it becomes necessary for them to grasp the methods of recovery. In this research, this author tries to investigate the mechanism and methods to recover athletes' joints from the fatigue and relax their nervous system.展开更多
For high-purity distillation processes,it is difficult to achieve a good direct product quality control using traditional proportional-integral-differential(PID)control or multivariable predictive control technique du...For high-purity distillation processes,it is difficult to achieve a good direct product quality control using traditional proportional-integral-differential(PID)control or multivariable predictive control technique due to some difficulties,such as long response time,many un-measurable disturbances,and the reliability and precision issues of product quality soft-sensors.In this paper,based on the first principle analysis and dynamic simulation of a distillation process,a new predictive control scheme is proposed by using the split ratio of distillate flow rate to that of bottoms as an essential controlled variable.Correspondingly,a new strategy with integrated control and on-line optimization is developed,which consists of model predictive control of the split ratio,surrogate model based on radial basis function neural network for optimization,and modified differential evolution optimization algorithm. With the strategy,the process achieves its steady state quickly,so more profit can be obtained.The proposed strategy has been successfully applied to a gas separation plant for more than three years,which shows that the strategy is feasible and effective.展开更多
This article compares two Latin poem dedications which may contain hidden sub-meanings and possible displays of a basic puzzle method called acrostics, each dedicated to the same nobleman. The Latin verse in 1579 by A...This article compares two Latin poem dedications which may contain hidden sub-meanings and possible displays of a basic puzzle method called acrostics, each dedicated to the same nobleman. The Latin verse in 1579 by Anthony Munday follows acrostic English poems and may refer to his patron as "a lover of Pallas Athena" (the Spear-shaker of Greek mythology). The Latin verse in Robert Greene's 1584 book may contain a Latin acrostic and appears to identify Cupid, the "winged Love," as a companion of the same patron as Munday's from five years earlier. That Cupid trope appears similar to "the little love god" allusions to Cupid in several of Shakespeare's sonnets (e.g., #s 153 and 154). More than these discussions, this article explores difficulties of translating from Latin into English, or vice versa, and the pitfalls which can occur.展开更多
The Merchant of Venice (1914), as one of the greatest works by Shakespeare, is a comedy. It addresses various themes. It is much more than a study of the struggles between Christians and Jews; it also deals with lov...The Merchant of Venice (1914), as one of the greatest works by Shakespeare, is a comedy. It addresses various themes. It is much more than a study of the struggles between Christians and Jews; it also deals with love and self-sacrifice, hatred and revenge, and friendship and marriage. It is a victory of Christians against Jews. But, at a more profound level, the play is ultimately a tragedy which functions as a cautionary exposure on the social problems of prejudice, hypocrisy and the family relationships. The paper begins by addressing the prejudice that is a dominant theme throughout the play. It also contends that the hypocrisy is prevalent in Venetian society. Then, Shylock, as the tragic hero in the play is analyzed. The final part deals with the problem of family relationships. By exposing grave deficiencies in Venetian Society, the play obliges us to make a critical moral judgment on humanity and establish correct philosophy of life and values展开更多
To solve the excessive huge scale problem of the traditional multi-bit digital artificial neural networks (ANN) hardware implementation methods, a bit-stream ANN construction method based on direct sigma-delta (Z-A...To solve the excessive huge scale problem of the traditional multi-bit digital artificial neural networks (ANN) hardware implementation methods, a bit-stream ANN construction method based on direct sigma-delta (Z-A) signal processing is presented. The bit-stream adder, multiplier and fully digital X-A modulator used in the bit-stream linear ANN are implemented in a field programmable gate array (FPGA). A bit-stream linear ANN based on these bit-stream modules is presented and implemented. To verify the function and performance of the bit-stream linear ANN, the bit-stream adaptive predictor and the bit-stream adaptive noise cancellation system are presented. The predicted result of the bit-stream adaptive predictor is very close to the desired signal. Also, the bit-stream adaptive noise cancellation system removes the electric power noise effectively.展开更多
Digital valve control servo system is studied in this paper. In order to solve the system problems of poor control precision and slow response time,a CMAC-PID( cerebellar model articulation controller-PID) compound co...Digital valve control servo system is studied in this paper. In order to solve the system problems of poor control precision and slow response time,a CMAC-PID( cerebellar model articulation controller-PID) compound control method is proposed. This compound controller consists of two components: one is a traditional PID for the feedback control to guarantee stability of the system; the other is the CMAC control algorithm to form a feed-forward control for achieving high control precision and short response time of the controlled plant. Then the CMAC-PID compound control method is used in the digital valve control servo system to improve its control performance. Through simulation and experiment,the proposed CMAC-PID compound control method is superior to the traditional PID control for enhancing stability and robustness,and thus this compound control can be used as a new control strategy for the digital valve control servo system.展开更多
In order to accurately and quickly identify the safety status pattern of coalmines,a new safety status pattern recognition method based on the extension neural network (ENN) was proposed,and the design of structure of...In order to accurately and quickly identify the safety status pattern of coalmines,a new safety status pattern recognition method based on the extension neural network (ENN) was proposed,and the design of structure of network,the rationale of recognition algorithm and the performance of proposed method were discussed in detail.The safety status pattern recognition problem of coalmines can be regard as a classification problem whose features are defined in a range,so using the ENN is most appropriate for this problem.The ENN-based recognition method can use a novel extension distance to measure the similarity between the object to be recognized and the class centers.To demonstrate the effectiveness of the proposed method,a real-world application on the geological safety status pattern recognition of coalmines was tested.Comparative experiments with existing method and other traditional ANN-based methods were conducted.The experimental results show that the proposed ENN-based recognition method can identify the safety status pattern of coalmines accurately with shorter learning time and simpler structure.The experimental results also confirm that the proposed method has a better performance in recognition accuracy,generalization ability and fault-tolerant ability,which are very useful in recognizing the safety status pattern in the process of coal production.展开更多
The methanolic extract of red seaweed Kappaphycus alvarezii was evaluated against three different cancer cell lines to study for its antiproliferative effect. Lung cancer cell line (NCIH 460), Colon cancer cell line...The methanolic extract of red seaweed Kappaphycus alvarezii was evaluated against three different cancer cell lines to study for its antiproliferative effect. Lung cancer cell line (NCIH 460), Colon cancer cell line (HCT 116) and Glial cell carcinoma (U 251) are the three selected cell lines investigated in this study. Different concentrations of methanol extract (0.01, 0.10, 1.00, 10.00 and 100.00 lag/mL respectively) of Kappaphycus alvarezii were prepared and screened by quantitative MTT (Microculture Tetrazolium) (3-(4, 5-dimethylthiazol)-2, 5-diphenyltetrazolium bromide) assay. MTT assay are the colorimetric assay which was applied to assess the viability and proliferation of cancer cells to determine the cytotoxicity of methanol extract ofK. alvarezii. The MTT test is based on the enzymatic reduction of the tetrazolium salt (MTT) to formazon crystals exclusively in living metabolically active cells developed purple color complex which was directly proportional to the viability of cells. To elucidate the in-vitro anticancer activity the Lethal Concentration (LC50), Growth Inhibition (GI50) and Total Growth Inhibition (TGI) of the extract were investigated individually for each cancer celt line. Analysis of the extract has shown good cytotoxicity in all tested cancer cell lines, with an IC50 of 55 μg/mL against NCIH460 and U251, 65 μg/mL for HCT116 respectively. GI50 was found to be 5 μg/mL for NCIH 460 and 10 μg/mL for HCT 116 and U251 cell lines. TGI was 19 μg/mL for NCIH 460, 29 μg/mL for HCT 116 and 25 μg/mL for U 251 cell lines. The cytotoxicity of the extract were significantly high in Lung Cancer Cell line (NCIH 460) when compared to Colon Cancer Cell line (HCT 116) and Glial Cell Carcinoma (U251) in the following order NCIH 460 〉 HCT 116 〉 U251.展开更多
A comprehensive quantification method of fatigue degree is proposed concerning subjective and objective quantifications.Using the fatigue degree test software,fatigue degree is objectively quantified by analyzing the ...A comprehensive quantification method of fatigue degree is proposed concerning subjective and objective quantifications.Using the fatigue degree test software,fatigue degree is objectively quantified by analyzing the reaction and operation abilities of drivers about traffic signals.By comparison experiment with that EEG signal based,multivariate statistical analysis and fusion identification based on BP neural network(BPNN) results show that the experimental procedure is simple and practical,and the proposed method can reveal the correlation between fatigue feature parameters and fatigue degree in theory,and also can achieve accurate and reliable quantification of fatigue degree,especially under the associated action of multiple fatigue feature parameters.展开更多
OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were...OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke.展开更多
基金The National Natural Science Foundation of China (No.60576028)the Natural Science Foundation of Higher Education Institutions of Jiangsu Province(No.11KJB510004)
文摘To solve the excessive huge scale problem of the traditional multi-bit digital artificial neural network(ANN) hardware implementation methods,a bit-stream ANN hardware implementation method based on sigma delta(ΣΔ) modulation is presented.The bit-stream adder,multiplier,threshold function unit and fully digital ΣΔ modulator are implemented in a field programmable gate array(FPGA),and these bit-stream arithmetical units are employed to build the bit-stream artificial neuron.The function of the bit-stream artificial neuron is verified through the realization of the logic function and a linear classifier.The bit-stream perceptron based on the bit-stream artificial neuron with the pre-processed structure is proved to have the ability of nonlinear classification.The FPGA resource utilization of the bit-stream artificial neuron shows that the bit-stream ANN hardware implementation method can significantly reduce the demand of the ANN hardware resources.
文摘A new chaos control method is proposed to take advantage of chaos or avoid it. The hybrid Internal Model Control and Proportional Control learning scheme are introduced. In order to gain the desired robust performance and ensure the system's stability, Adaptive Momentum Algorithms are also developed. Through properly designing the neural network plant model and neural network controller, the chaotic dynamical systems are controlled while the parameters of the BP neural network are modified. Taking the Lorenz chaotic system as example, the results show that chaotic dynamical systems can be stabilized at the desired orbits by this control strategy.
文摘Arguably, Africa comparatively remains a huge account for narratives within the context of repository of misery and violence in the 21 st-century, an attempt to political development has posed an irresistible challenge and a disturbing necessity for Mia Couto in Voices Made Night (1990) and Bessie Head in Tales of Tenderness and Power (1989). The position of Couto as a white Mozambican writer and Head as an exiled coloured South African writer, living in her adopted country of Botswana, provides them with privileged neutrality from which to view the effect of the admixture of grinding poverty and violence as they ravage the landscapes of these countries. While Couto does not fail to incorporate the significance of power struggle between FRELIMO (Front for the Liberation of Mozambique) and RENAMO (Mozambique National Resistance) in the ~'oices Made Night, Head's articulation of the complex manipulation of power becomes a resource for constructing a discourse of nationalism in Tales of Tenderness and Power. The paper intends to focus on the correlation between power and economic development in these anthologies. The paper will further examine how political power impacts on the socio-economic well being of the local folks in the Couto's Mozambique and Head's South Africa.
文摘After athletes' intensive training and competition, they would suffer from fatigue. Therefore, the measures to recover their motor and nervous systems from the fatigue are very important. In this research, this author tries to investigate the methods to recover one' s joints and relax one' s nervous system, and detailed methods would also be provided for reference. Objective conditions, like sports fields and equipment, have become relatively satisfactory. There are high-level coaches and athletes who are carefully and scientifically chosen, so that good athletic performance is well guaranteed. To improve sports teams' comprehensive sports skills, we have to adopt and grasp some advanced training methods and skills. But after intensive training and fierce competition, athletes' motor and nervous system would suffer from fatigue, therefore, it becomes necessary for them to grasp the methods of recovery. In this research, this author tries to investigate the mechanism and methods to recover athletes' joints from the fatigue and relax their nervous system.
基金Supported by the National High Technology Research and Development Program of China(2007AA04Z193) the National Natural Science Foundation of China(60974008 60704032)
文摘For high-purity distillation processes,it is difficult to achieve a good direct product quality control using traditional proportional-integral-differential(PID)control or multivariable predictive control technique due to some difficulties,such as long response time,many un-measurable disturbances,and the reliability and precision issues of product quality soft-sensors.In this paper,based on the first principle analysis and dynamic simulation of a distillation process,a new predictive control scheme is proposed by using the split ratio of distillate flow rate to that of bottoms as an essential controlled variable.Correspondingly,a new strategy with integrated control and on-line optimization is developed,which consists of model predictive control of the split ratio,surrogate model based on radial basis function neural network for optimization,and modified differential evolution optimization algorithm. With the strategy,the process achieves its steady state quickly,so more profit can be obtained.The proposed strategy has been successfully applied to a gas separation plant for more than three years,which shows that the strategy is feasible and effective.
文摘This article compares two Latin poem dedications which may contain hidden sub-meanings and possible displays of a basic puzzle method called acrostics, each dedicated to the same nobleman. The Latin verse in 1579 by Anthony Munday follows acrostic English poems and may refer to his patron as "a lover of Pallas Athena" (the Spear-shaker of Greek mythology). The Latin verse in Robert Greene's 1584 book may contain a Latin acrostic and appears to identify Cupid, the "winged Love," as a companion of the same patron as Munday's from five years earlier. That Cupid trope appears similar to "the little love god" allusions to Cupid in several of Shakespeare's sonnets (e.g., #s 153 and 154). More than these discussions, this article explores difficulties of translating from Latin into English, or vice versa, and the pitfalls which can occur.
文摘The Merchant of Venice (1914), as one of the greatest works by Shakespeare, is a comedy. It addresses various themes. It is much more than a study of the struggles between Christians and Jews; it also deals with love and self-sacrifice, hatred and revenge, and friendship and marriage. It is a victory of Christians against Jews. But, at a more profound level, the play is ultimately a tragedy which functions as a cautionary exposure on the social problems of prejudice, hypocrisy and the family relationships. The paper begins by addressing the prejudice that is a dominant theme throughout the play. It also contends that the hypocrisy is prevalent in Venetian society. Then, Shylock, as the tragic hero in the play is analyzed. The final part deals with the problem of family relationships. By exposing grave deficiencies in Venetian Society, the play obliges us to make a critical moral judgment on humanity and establish correct philosophy of life and values
基金Supported by the National Natural Science Foundation of China (No. 60576028) and the National High Technology Research and Development Program of China (No. 2007AA01Z2a5)
文摘To solve the excessive huge scale problem of the traditional multi-bit digital artificial neural networks (ANN) hardware implementation methods, a bit-stream ANN construction method based on direct sigma-delta (Z-A) signal processing is presented. The bit-stream adder, multiplier and fully digital X-A modulator used in the bit-stream linear ANN are implemented in a field programmable gate array (FPGA). A bit-stream linear ANN based on these bit-stream modules is presented and implemented. To verify the function and performance of the bit-stream linear ANN, the bit-stream adaptive predictor and the bit-stream adaptive noise cancellation system are presented. The predicted result of the bit-stream adaptive predictor is very close to the desired signal. Also, the bit-stream adaptive noise cancellation system removes the electric power noise effectively.
基金Supported by the National Natural Science Foundation of China(No.51505412)the Independent Study Program for Young Teachers in Yanshan University(No.14LGB004)
文摘Digital valve control servo system is studied in this paper. In order to solve the system problems of poor control precision and slow response time,a CMAC-PID( cerebellar model articulation controller-PID) compound control method is proposed. This compound controller consists of two components: one is a traditional PID for the feedback control to guarantee stability of the system; the other is the CMAC control algorithm to form a feed-forward control for achieving high control precision and short response time of the controlled plant. Then the CMAC-PID compound control method is used in the digital valve control servo system to improve its control performance. Through simulation and experiment,the proposed CMAC-PID compound control method is superior to the traditional PID control for enhancing stability and robustness,and thus this compound control can be used as a new control strategy for the digital valve control servo system.
基金Project(107021) supported by the Key Foundation of Chinese Ministry of Education Project(2009643013) supported by China Scholarship Fund
文摘In order to accurately and quickly identify the safety status pattern of coalmines,a new safety status pattern recognition method based on the extension neural network (ENN) was proposed,and the design of structure of network,the rationale of recognition algorithm and the performance of proposed method were discussed in detail.The safety status pattern recognition problem of coalmines can be regard as a classification problem whose features are defined in a range,so using the ENN is most appropriate for this problem.The ENN-based recognition method can use a novel extension distance to measure the similarity between the object to be recognized and the class centers.To demonstrate the effectiveness of the proposed method,a real-world application on the geological safety status pattern recognition of coalmines was tested.Comparative experiments with existing method and other traditional ANN-based methods were conducted.The experimental results show that the proposed ENN-based recognition method can identify the safety status pattern of coalmines accurately with shorter learning time and simpler structure.The experimental results also confirm that the proposed method has a better performance in recognition accuracy,generalization ability and fault-tolerant ability,which are very useful in recognizing the safety status pattern in the process of coal production.
文摘The methanolic extract of red seaweed Kappaphycus alvarezii was evaluated against three different cancer cell lines to study for its antiproliferative effect. Lung cancer cell line (NCIH 460), Colon cancer cell line (HCT 116) and Glial cell carcinoma (U 251) are the three selected cell lines investigated in this study. Different concentrations of methanol extract (0.01, 0.10, 1.00, 10.00 and 100.00 lag/mL respectively) of Kappaphycus alvarezii were prepared and screened by quantitative MTT (Microculture Tetrazolium) (3-(4, 5-dimethylthiazol)-2, 5-diphenyltetrazolium bromide) assay. MTT assay are the colorimetric assay which was applied to assess the viability and proliferation of cancer cells to determine the cytotoxicity of methanol extract ofK. alvarezii. The MTT test is based on the enzymatic reduction of the tetrazolium salt (MTT) to formazon crystals exclusively in living metabolically active cells developed purple color complex which was directly proportional to the viability of cells. To elucidate the in-vitro anticancer activity the Lethal Concentration (LC50), Growth Inhibition (GI50) and Total Growth Inhibition (TGI) of the extract were investigated individually for each cancer celt line. Analysis of the extract has shown good cytotoxicity in all tested cancer cell lines, with an IC50 of 55 μg/mL against NCIH460 and U251, 65 μg/mL for HCT116 respectively. GI50 was found to be 5 μg/mL for NCIH 460 and 10 μg/mL for HCT 116 and U251 cell lines. TGI was 19 μg/mL for NCIH 460, 29 μg/mL for HCT 116 and 25 μg/mL for U 251 cell lines. The cytotoxicity of the extract were significantly high in Lung Cancer Cell line (NCIH 460) when compared to Colon Cancer Cell line (HCT 116) and Glial Cell Carcinoma (U251) in the following order NCIH 460 〉 HCT 116 〉 U251.
基金Supported by the National Nature Science Foundation of China(No.61304205,61203273,61103086,41301037)the Open Funding Project of State Key Laboratory of Virtual Reality Technology and Systems,Beihang University(No.BUAA-VR-13KF-04)+1 种基金Jiangsu Ordinary University Science Research Project(No.13KJB120007)Innovation and Entrepreneurship Training Project of College Students(No.201410300153,201410300165)
文摘A comprehensive quantification method of fatigue degree is proposed concerning subjective and objective quantifications.Using the fatigue degree test software,fatigue degree is objectively quantified by analyzing the reaction and operation abilities of drivers about traffic signals.By comparison experiment with that EEG signal based,multivariate statistical analysis and fusion identification based on BP neural network(BPNN) results show that the experimental procedure is simple and practical,and the proposed method can reveal the correlation between fatigue feature parameters and fatigue degree in theory,and also can achieve accurate and reliable quantification of fatigue degree,especially under the associated action of multiple fatigue feature parameters.
基金Supported by the National Natural Science Foundation of China:Effect of Moxibustion on"Longevity Gene"SIRT1 Regulation in Aged Mice(No.81403449)NSFC Project:Effect of Moxibustion and its Therapeutic Factors on Mitochondrial Energy Metabolism and Apotosis Pathyway in APP/PS1Transgenic Alzheimer's Disease Mouse Model(No.81574068)National Program on Key Basic Research Project(973 Program):the Study of Components and Mechanisms of Artemisia and the Product and Moxibustion and Safety Evaluation(No.2009CB522906)
文摘OBJECTIVE: To evaluate the effects that inhalation of the combustion products of the traditional Chinese herb Aiye(Folium Artemisiae Argyi) has on the central nervous system.METHODS: Forty Kunming mice(half male) were randomly assigned(n = 10/group) to a control group(C) or one of three moxa smoke concentration groups(% opacity): low(L1; 0.4%), medium(M1; 2%), and high(H1; 15%). Mice in the latter three groups were exposed to moxa smoke in a dynamic gas exposure cabinet for 20 min per day for7 days. Mice in control group were placed in the same cabinet without any intervention. For the sleep experiments, another 50 mice were divided into five groups of 10 mice each: a saline-injected control group, L1 + pentobarbital sodium(PS)-injected group, M1+PS group, H1(15%)+PS group,and a positive control group(10 mg/kg, chlorpromazine, p.o.). The weight, general activities, locomotor activities, rotarod performance, sleep duration,and sleeping rate induced by a subthreshold dose of pentobarbital sodium were recorded in the mice,and the composition of moxa smoke was analyzed using headspace gas chromatography(GC-HS).RESULTS: A low concentration of smoke significantly decreased the frequency of locomotor activities and the time for which the mice remaining on the rotarod; however, a high smoke concentration significantly prolonged the pentobarbital-induced sleeping time and sleeping rate.CONCLUSION: The concentration-dependent relaxing effects of moxa smoke on the Central Nervous System(CNS) were confirmed. Moreover, GC-HS analysis showed that the component present in the highest concentration in moxa smoke was eucalyp-tol, an essential oil well recognized for its soothing effects on the CNS. This may therefore be accountable for the sedative effects of moxa smoke.