Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the resul...Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.展开更多
1877年1月15日,在当时匈牙利的克劳森堡(今属罗马尼亚,称克卢日)出版了一本与众不同的杂志。杂志前言宣称它只有一个"天职",就是"传播美的圣谕"。这就是简称为"ACLU"的世界第一本比较文学杂志。这个事业...1877年1月15日,在当时匈牙利的克劳森堡(今属罗马尼亚,称克卢日)出版了一本与众不同的杂志。杂志前言宣称它只有一个"天职",就是"传播美的圣谕"。这就是简称为"ACLU"的世界第一本比较文学杂志。这个事业的主要开创者是梅茨尔(Hugo von Metzl,1846—1908)。他出身于匈牙利的一个日耳曼民族家庭,母语是德语,但自小就学习匈牙利语、罗马尼亚语、英语、法语等数种欧洲语言。以后他在德国的来比锡和海德堡学习哲学、日耳曼学。1872年以论文《文科中学教学法中哲学的地位。展开更多
本文为戴地安新著《希腊人与我们》(Les grecs et nous)的纲领性导言,也是他多年来从事古希腊宗教研究的一个方法论总结,提出了以比较人类学方法研究古希腊文明的论点。作者反对从西方中心论的角度看待希腊文明,而主张历史学的取向与人...本文为戴地安新著《希腊人与我们》(Les grecs et nous)的纲领性导言,也是他多年来从事古希腊宗教研究的一个方法论总结,提出了以比较人类学方法研究古希腊文明的论点。作者反对从西方中心论的角度看待希腊文明,而主张历史学的取向与人类学的取向相结合,把希腊宗教文化放在世界多元文化的格局下来研究。展开更多
基金supported by the National Natural Science Foundation of China (31123005)the Chinese Academy of Sciences (Y002731071)the National Basic Research Program of China (2009CB941300)
文摘Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.
文摘1877年1月15日,在当时匈牙利的克劳森堡(今属罗马尼亚,称克卢日)出版了一本与众不同的杂志。杂志前言宣称它只有一个"天职",就是"传播美的圣谕"。这就是简称为"ACLU"的世界第一本比较文学杂志。这个事业的主要开创者是梅茨尔(Hugo von Metzl,1846—1908)。他出身于匈牙利的一个日耳曼民族家庭,母语是德语,但自小就学习匈牙利语、罗马尼亚语、英语、法语等数种欧洲语言。以后他在德国的来比锡和海德堡学习哲学、日耳曼学。1872年以论文《文科中学教学法中哲学的地位。
文摘本文为戴地安新著《希腊人与我们》(Les grecs et nous)的纲领性导言,也是他多年来从事古希腊宗教研究的一个方法论总结,提出了以比较人类学方法研究古希腊文明的论点。作者反对从西方中心论的角度看待希腊文明,而主张历史学的取向与人类学的取向相结合,把希腊宗教文化放在世界多元文化的格局下来研究。
