人,总要有点心气儿

在这年节当中，鞭炮长鸣，灯红遍地，喧哗中洒扫庭除，装饰点缀，出厅入店，常常脚不沾地，虽然似乎很是忙碌，可内心总有一种莫名的躁动。渐渐似乎演变成一种慌张。凝眉思量，心里一个声音悄悄说：“你又偷闲了好多时日!”是啊，我的确与我的工作远离了好多时日。我如今的生活毕竟无需“偷得”半日闲，而是毫无疑义地拥有更多闲时。在这一个月的假期里，我忙着过日子了，忙着邻里亲朋东拉西扯了．我的空间日志里却连半篇都未更新。这怎能不说是悠闲的时日呢？

CPAP结合肺泡表面活性物质治疗新生儿呼吸窘迫综合征的疗效观察

目的分析CPAP结合肺泡表面活性物质治疗新生儿呼吸窘迫综合征的临床疗效。方法选取我院2016年2月—2017年4月收治的新生儿呼吸窘迫综合征患儿40例作为研究对象。通过抽签法,将其均分为观察组和对照组,每组各20例患儿。对照组患儿采用肺泡表面活性物质进行治疗,观察组患儿采用CPAP结合肺泡表面活性物质进行治疗。结果治疗前,观察组和对照组患者PaO_2、PaCO_2、PaO_2/FiO_2和pH值比较,差异无统计学意义(P>0.05)。治疗后,观察组患者PaO_2、PaCO_2、PaO_2/FiO_2和pH值与对照组比较,差异具有统计学意义(P<0.05)。结论新生儿呼吸窘迫综合征经CPAP结合肺泡表面活性物质治疗疗效确切。

Gas emission source term estimation with 1-step nonlinear partial swarm optimization-Tikhonov regularization hybrid method

Source term identification is very important for the contaminant gas emission event. Thus, it is necessary to study the source parameter estimation method with high computation efficiency, high estimation accuracy and reasonable confidence interval. Tikhonov regularization method is a potential good tool to identify the source parameters. However, it is invalid for nonlinear inverse problem like gas emission process. 2-step nonlinear and linear PSO （partial swarm optimization）-Tikhonov regularization method proposed previously have estimated the emission source parameters successfully. But there are still some problems in computation efficiency and confidence interval. Hence, a new 1-step nonlinear method combined Tikhonov regularizafion and PSO algorithm with nonlinear forward dispersion model was proposed. First, the method was tested with simulation and experiment cases. The test results showed that 1-step nonlinear hybrid method is able to estimate multiple source parameters with reasonable confidence interval. Then, the estimation performances of different methods were compared with different cases. The estimation values with 1-step nonlinear method were close to that with 2-step nonlinear and linear PSO-Tikhonov regularization method, 1-step nonlinear method even performs better than other two methods in some cases, especially for source strength and downwind distance estimation. Compared with 2-step nonlinear method, 1-step method has higher computation efficiency. On the other hand, the confidence intervals with the method proposed in this paper seem more reasonable than that with other two methods. Finally, single PSO algorithm was compared with 1-step nonlinear PSO-Tikhonov hybrid regularization method. The results showed that the skill scores of 1-step nonlinear hybrid method to estimate source parameters were close to that of single PSO method and even better in some cases. One more important property of 1-step nonlinear PSO-Tikhonov regularization method is its reasonable confidence interval, which is not obtained by single PSO algorithm. Therefore, 1-step nonlinear hybrid regularization method proposed in this paper is a potential good method to estimate contaminant gas emission source term.

EFFECTS OF ALFENTANIL AND ESMOLOL ON HEMODYNAMIC AND CATECHOLAMINE RESPONSE TO TRACHEAL INTUBATION

Objective.To compare the effects of alfentanil and esmolol on hemodynamic and catecholamine response to tracheal intubation. Methods.Thirty five adult patients were randomly allocated to one of three groups,Group A(control group),Group B(esmolol group)and Group C(alfentanil group).The patients received either 2 mg/kg esmolol(in Group B)or 30 μg/kg alfentanil(in Group C)before intubation.Tracheal intubation was performed with 4 mg/kg thiopental and 0 1 mg/kg vecuronium and 3% isoflurane.Systolic blood pressure(SBP),diastolic blood pressure(DBP),mean blood pressure(MBP),heart rate(HR),norepinephrine(NE),epinephrine(E)and dopamine(DA)were measured before and after intubation. Results.The control group had a baseline SBP of 149±23 mmHg while Groups B,C had a baseline SBP of 148±23,and 150±21mmHg,respectively(P>0 05).Three min after tracheal intubation,the control group SBP increased to 160±30 mmHg and Group B remained at the baseline level,147±5 mmHg,and Group C significantly decreased to 91±22 mmHg(P<0 01).Two min after intubation HR in Group B increased significantly but 3 min after intubation HR in Groups B and C were significantly lower than that of control group(P<0 05).NE in Groups A and B increased significantly to 5 75±3 51 and 6 75±3 30 nmol/L 3 min after intubation(P<0 01).In Group C,3 min after intubation NE was not significantly different from the baseline but E decreased significantly(P<0 01). Conclusion.2 mg/kg esmolol can moderate the hemodynamic response to tracheal intubation to a certain extent and 30μg/kg alfentanil can completely attenuate the hemodynamic and catecholamine responses.

Coordination and nursing care of pediatric patients undergoing double balloon enteroscopy

AIM:To review safety,efficacy,and proper nursing care of double-balloon enteroscopy (DBE) in pediatric patients with small intestinal disease.METHODS:Our study included 37 patients with abdominal pain,diarrhea,passage of blood in the stools,and other symptoms,who underwent DBE from December 2006 to July 2010.DBE was retrograde in 36 procedures,antegrade in six,and from both ends in five.The diagnostic significance and salient points in nursing care are discussed in this article.RESULTS:At least one lesion was discovered in 28 out of 37 patients,which yielded a positive diagnosis in 75.7% of cases.Good bowel preparation and skilled nursing care not only shortened the procedure time,but could also alleviate patient discomfort and enhance the quality of examination.No serious procedure-related complications were observed in any cases.CONCLUSION:DBE is a new modality of endoscopic procedure that improves the standard of diagnosis and treatment of small bowel diseases in children.Good nursing care is essential to the successful execution of the procedure.

THE STUDY ON RELATED GENES IN THE NEOPLASTIC TRANSFORMATION OF IMMORTALIZED HUMAN FETAL TRACHEAL FIBROBLAST CELLS INDUCED BY IRRADIATION

In this study, we investigated the genes related to the transformation of immortalized human fetal tracheal fibroblast cell line induced by alpha particles by means of differential display mRNA method. The result revealed that there were 23 DNA fragments that were expressed intensively in alphaSHTF cells (SHTF cells forming clone on agar after irradiated by alpha particles emitted by 238Pu) only and not in SHTF (SV40-immortalized human fetal tracheal fibroblast) cells. Northern dot confirmed two fragments, C17-5, C23-1 which showed intensive mRNA expression in alphaSHTF cells, but not in SHTF cells. The length of the C17-5 fragment was 310bp. Searching in BLAST database revealed that the C17-5 fragment might be an unknown sequence.

Analysis of interprovincial trade embodied carbon emissions in Beijing-Tianjin-Hebei and surrounding provinces: based on constructed MRIO Model

The interprovincial trade embodied carbon emissions plays an important role in the national emission reduction target among China's provinces. Furthermore, it will affect the smooth start-up of the national carbon trade market as well as the implementation of targets in 2030 for dealing with the climate change. Based on constructed MRIO model, this paper analyzes the embodied carbon emission trade flows among Beijing, Tianjin, Hebei and surrounding regions such as Shanxi, Shaanxi, and Inner Mongolia. The results indicate that six provinces have formed different patterns of carbon trade balance, where Beijing, Tianjin, and Hebei provinces are in a deficit position, while the other three provinces are in a surplus position.Beijing, Tianjin, and Hebei have transferred part of the carbon emissions to the other three provinces, which shows greater heterogeneity among various provinces and provincial different sectors. On basis of the conclusions, this paper puts forward some suggestions on provincial decomposition, responsibility distribution, and provincial collaborative reduction for national emission reduction targets.

Dietary treatment of colic caused by excess gas in infants:Biochemical evidence

AIM:To evaluate the impact of feeding colicky infants with an adapted formula on the hydrogen breath test and clinical symptoms.METHODS:Hydrogen expiration was measured by SC MicroLyzer gas chromatography at inclusion and 15 d after treatment with an adapted low-lactose formula in 20 colicky infants.RESULTS:All babies were symptomatic:85% with excess gas,75% with abnormal feeding pattern,and 85% with excessive crying.The hydrogen breath test at inclusion was abnormal:35 ± 3.1 ppm.After 15 d feeding with an adapted low-lactose formula,crying and flatulence decreased in 85% of patients (P < 0.001).For infants in whom no decrease of gas was reported,crying was still reduced (P < 0.01).Moreover,the feeding pattern was improved in 50% of infants when it was initially considered as abnormal.Finally,the hydrogen breath test decreased significantly (10 ± 2.5 ppm,P < 0.01).CONCLUSION:This study showed an association between clinical improvement and evidence of decreased levels of hydrogen when the infants were fed with a specially designed,low-lactose formula.

Carbon Footprint Analysis for Baby Strollers

The increasing awareness of climate change has led organizations to demand a standard procedure to measure and communicate greenhouse gas(GHG) emissions linked to their products or services.The publicly available specification PAS 2050 has been developed in response to broad community and industry desire for a consistent method-carbon footprint for assessing the life cycle GHG emissions of goods and services.Specifically,this paper illustrates the implementation of carbon footprint for a baby stroller in accordance with PAS 2050.A fial value of 321 kg per one stroller including package was calculated.Moreover,the study led to identify raw materials production of the stroller as the main source of GHS emissions where efforts need to focus for emission reduction opportunities.This case study is hoped to be a starting point for organizations to benefit from the increasing application of carbon footprint assessment.

The effect of different inflation volumes of laryngeal mask airway on efficacy of closed circuit controlled ventilation in pediatric cancer patients

Objective： The laryngeal mask airway （LMA） is an established way for airway control during spontaneous ventila- tion. Its ability to deliver positive pressure ventilation without leakage especially in low flow states is still controversy. The aim of this study is to test the possibility of using LMA in pediatric closed circuit controlled ventilation, and to find out the optimum cuff volume to perform closed system ventilation. Methods： Twenty children scheduled for elective surgeries were enrolled in a crossover study. Laryngeal mask airway was used. In stage I, the cuff was inflated with the maximum volume of air as rec- ommended by the manufacturers. Adjustment of volume of air inflated into the LMA cuff to the minimum volume to obtain the effective seal was done at stage II. The leak pressure, intracuff pressure and the leak volume were measured in both stages. Results： The cuff filling volume was significantly lower compared to the maximum cuff inflation volume in stage I. Leakage values showed significantly less values in stage II of the study with smaller cuff inflation volumes. The airway leakage pressure was significantly lower in stage fl in comparison to stage I. Cuff inflation pressure in stage I showed marked elevation which dropped significantly after adjustment of cuff volume in stage I1. Conclusion： Laryngeal mask airway is an effective tool to provide closed circuit controlled ventilation in pediatrics. Inflation of the cuff by the minimum volume of air needed to reach the just sealing pressure is suggested to minimize the leakage volume.

Modeling the Flow Regime Near the Source in Underwater Gas Releases

Recent progress in calculating gas bubble sizes in a plume, based on phenomenological approaches using the release conditions is a significant improvement to make the gas plume models self-reliant. Such calculations require details of conditions Near the Source of Plume （NSP）; （i.e. the plume/jet velocity and radius near the source）, which inspired the present work. Determining NSP conditions for gas plumes are far more complex than that for oil plumes due to the substantial density difference between gas and water. To calculate NSP conditions, modeling the early stage of the plume is important. A novel method of modeling the early stage of an underwater gas release is presented here. Major impact of the present work is to define the correct NSP conditions for underwater gas releases, which is not possible with available methods as those techniques are not based on the physics of flow region near the source of the plume/jet. We introduce super Gaussian profiles to model the density and velocity variations of the early stages of plume, coupled with the laws of fluid mechanics to define profile parameters. This new approach, models the velocity profile variation from near uniform, across the section at the release point to Gaussian some distance away. The comparisons show that experimental data agrees well with the computations.

Anteroposterior cricoid split interposition costal cartilage grafts for laryngotracheal stenosis in children

Objective: To investigate the effects of anteroposterior cricoid spliting interposition costal grafting for moderate and severe laryngotracheal stenosis in children. Methods: From 1995 to 2005, 87 children (aged 1. 2 to 14 years) with moderate and severe glottic and subglottic stenosis were retrospectively studied. They were operated with cricoid spliting laryngotracheal reconstruction in our hospital. All of 87 patients were tracheostomy-dependent before surgery. Results: Eighty-five patients (95%) were successfully decannnulated and got an effective phonation. The follow-up time was more than 5 years. The effect of operation was satisfactory and the growth and development of children was normal. Conclusion: Anteroposterior cricoid split interposition costal cartilage graft is a safe and effective treatment method for moderate and severe glottic and subglottic stenosis in children.

Prof.Xiao Shaoqin's Experience in Acupuncture Treatment

Having been engaged in TCM for 50 years, Prof. Xiao Shaoqin has got rich experience in acupuncture. The author has pursued advanced studies for 3 years under his guidance, and has learned a lot from him. The following is a report of Prof. Xiao Shaoqin's experience for treating 3 typical eases.

A Report for the Therapeutic Effects of Asthma Plaster in the Treatment of 139 Asthmatic Children

In June 1994, asthma plaster was developed, which has proved effective in the treatment of cold-type asthma by applying it on some acupoints, which are known to be good for asthma.

Comparative Study of the Impact of Climate Variability on Prevalence of Urinary Schistosomiasis： Cases at Sunyani Regional Hospital and among School Children in Atronie, Sunyani

A study has been conducted to determine the impact of climate variability on Schistosoma haematobium infection among patients and school children in Sunyani between 2006 and 2009. Urine samples from the subjects were collected and examined in the laboratory using the Filteration technique for the detection and quantification ofSchistosoma haematobium eggs. The prevalence rate of urinary schistosomiasis at the Sunyani Regional Hospital for 2006, 2007, 2008 and 2009 were found to be 0.24%, 0.55%, 0.55% and 0.75% respectively while that for Methodist Junior High School in 2008 and 2009 were 60.1% and 60.3% respectively. A decrease in the relative humidity and average annual rainfall were identified as factors contributory to the increase in urinary schistosomiasis prevalence rate. The temperature values obtained throughout the study period did not have any significant effect on the prevalence rate. The temperature values, however, were those that enhanced cercarial incubation （15-35 ℃） with a resultant increase in shedding of cercariae leading to more infections among water contacts. The infection rate due to the stream Amama was 20.1%, while that due to river Tano was 36.6%. The highest risk group was children aged 15-19 years. Praziquantel was administered to treat the infection, producing a cure rate of 93%. Recognition of urinary schistosomiasis as a public health problem in Ghana is the main challenge to prevention and control of the disease.

Treatment of Pediatric Diseases by the Method of Evacuating the Bowels to Remove the Internal Heat

Evacuating the bowels to remove internal heat is one of the major therapeutic principles in treating pediatric diseases. Since the children are incapable of controlling in take of milk or food, the accumulated foodstuffs in the body will impede the spleen and stomach in digestion and transportation. In addition, children are easy to be attacked by exopathogens, because their organs are tender and do not fully develop. Once an exopathogen gets into the interior, it will transform into heat. However, simple measures of eliminating the heat often fail in the treatment of some critical and emergent pediatric cases. We have treated such cases by the method of evacuating bowels to remove the internal heat with miracle effects and would like to share our experience with our colleagues. The following are some examples.

TEMPORAL EXPRESSION OF NOTCH RECEPTORS DURING LUNG DEVELOPMENT IN RAT

Objective To investigate the temporal expression of Notch receptors in developing lungs of rats and to explore the regulating role of Notch in lung development. Methods We studied the expression of Notch1,2,3 isforms in embryonic days 18,20,21 and postnatal days 1,4,7,14, 21 rat lungs. Six rats of each group were used to assess lung histologic changes by HE staining and expression of Notch in lungs by immunohistochemistry. Total RNA was extracted by Trizol reagent from the frozen lung tissues. mRNA levels of Notch were measured by reverse transcription polymerase chain reaction (RT-PCR). Results It is showed that Notch_ 1-3 mainly localized in the airway surface epithelium、alveolar epithelium during the psdueoglandular stage, and reached the peaks at canalicular period. The expression patterns of Notch_ 1-3 were changed with the fetal age. Conclusion These results support multiple roles for Notch1,2,and 3 receptor activation during lung development, probably not only modulating the process of branching morphogenesis but also involved in determining the cell differentiation fate in fetal alveolar epithelium.

Treatment of Cough and Dyspnea due to Acute Bronchitis by Plaster for Cough and Dyspnea——A Report of 735 Cases

In the light of the theory of treating the internal disease externally, an externally used plaster for treating cough and dyspnea due to acute bronchitis (Ke Chuan Yi Tie Kang [symbol: see text]-[symbol: see text]) was successfully applied to 735 cases of acute bronchitis (the treatment group), with the other 423 cases treated with routine western drugs as controls. The results showed that the cure rate in the treatment group was significantly higher than that in the control group (P

CLINICAL OBSERVATION ON 25 CASES OF HORMONE DEPENDENT BRONCHIAL ASTHMA TREATED BY ACUPUNCTURE

The clinical observation revealed that the asthmatic symptoms in most of the patients began to be improved after several acupuncture treatments with the dosage of the drug gradually reduced. Generally, the dose of cortisone per os was decreased by 2 mg every 10 days, while that of aerosol was controlled by the patients themselves according to the condition of the disease. The symptoms in most of the patients were markedly improved after 15 treatments, but the treatment should be continued for another 10 times to consolidate the curative effect. Thus, each asthmatic patient needs to receive approximately 30 sessions of acupuncture treatment, lasting about 3 months. Thereafter, in order to prevent its relapse, the treatment should be administered 10 times each year in the summer season. It is worthy to be mentioned that, in this series, there was a female patient who suffered from anaphylactic asthma induced by dog's hair. She received 10 sessions of acupuncture treatment with no any improvement. In this case, the acupuncture treatment should not be given any longer. There were another two children patients aged 5 and 7 years respectively, for them the above method of acupuncture treatment was difficult to be used. Therefore, the auricular pressing method combined with cupping was adopted instead. The auricular points selected were Shenmen, Lung, Large Intestine, sensitive point, Pingchuan, Subcortex, and Kidney. 5 points were used each time, and pressed with the seeds of Vaccaria which were changed every 3 days. The patients were asked to press each of the points themselves 3 times a day (each time by 20 pressings). And Dazhui (Du 14), Feishu (UB 13), Pishu (UB 20) and Shenshu (UB 23) were cupped for 5 min. each time. The auricular pressing and cupping therapies may also be added for adult patients to strengthen the curative effect. The 25 cases of hormone dependent bronchial asthma were treated by acupuncture, yielding a markedly effective rate of 56% with a total effective rate of 96%, indicating that good therapeutic results can also be expected in the western countries for those cases who have already been treated with hormones.

遥里空间:关于茶的仪式感

去年年初,遥里茶事开业,到现在已经一年多时日。在一个城市里,茶空间就像是一个“精神堡垒”,由茶叶,技法,物件的逐渐发酵,到美学,文化的相互交融,最终影响到人的内心和生活态度。成都是泡在茶里的,只是早年茶馆遍街的市井形态已悄然逝去,留下零星点缀,比如彭镇茶馆、鹤鸣茶社。去的人,与其说是追忆过去,不如说是过过“复古”的新鲜劲儿。更多新兴的茶空间赶着趟儿的逐渐兴起,风格各异,又少了那么些地气儿。