To compare effect of high-frequency oscillation ventilation （HFOV） and conventional mandatory ventilation （CMV） on lung injury development in rabbit with acute respiratory distress syndrome （ ARDS）. Methods Anim...To compare effect of high-frequency oscillation ventilation （HFOV） and conventional mandatory ventilation （CMV） on lung injury development in rabbit with acute respiratory distress syndrome （ ARDS）. Methods Animals that underwent saline lung lavage to produce lung injury were randomized to one of the two treatment groups （ HFOV or CMV, n =6）. PaCO2 was maintained between 35 -45mmHg and arterial oxygen saturation （ SaO2 ） was maintain 〉 88% by adjusting corresponding ventilator parameters. Ventilation period was 6h. Lung fluids were aspirated before and at the end of ventilation for cell analysis. Then the animals were euthanized, lung tissue was removed for wet/dry weight measurement, light and electron microscopic examination. Besults The difference of artery blood gas analyses（pH, PaO2, PaCO2 ） between HFOV and CMV was insignificant. The difference between HFOV and CMV in cytological examination of lung fluids, wet/dry weight measurement was also insignificant. But compared with CMV, HFOV not only reduced the area of lung injury, but also reduced lung injury score in light and electron microscopic examination. Conclusion When same artery blood gas analysis was obtained, HFOV significantly reduced lung injury development in ARDS animal than CMV. As a lung protection strategy, HFOV can be used in the treatment of ARDS.展开更多
Laser was coupled into an optical fiber,on which covered a layer of well-aligned carbon nanotubes(CNTs)serving as cathode,to tune the field emission of the cathode.CNT arrays as field emission cathode were synthesized...Laser was coupled into an optical fiber,on which covered a layer of well-aligned carbon nanotubes(CNTs)serving as cathode,to tune the field emission of the cathode.CNT arrays as field emission cathode were synthesized by chemical vapor deposition(CVD)on a naked fiber core.When the laser was coupled into the fiber,the turn-on voltage(Vto at a current density of 1 mA cm?2)decreased from 1.0 to 0.9 kV and the emission current density increased from 0.83 mA cm?2(at a 1 kV bias voltage)to3.04 mA cm?2 on 40μm diameter fiber.A photon absorption mechanism is attributed to the field emission improvement.The estimated effective work function of CNT arrays on the optical fiber decrease from 4.89 to 4.29 eV.The results show the possibility of constructing a waveguide type laser modulated field emission cathode.展开更多
文摘To compare effect of high-frequency oscillation ventilation （HFOV） and conventional mandatory ventilation （CMV） on lung injury development in rabbit with acute respiratory distress syndrome （ ARDS）. Methods Animals that underwent saline lung lavage to produce lung injury were randomized to one of the two treatment groups （ HFOV or CMV, n =6）. PaCO2 was maintained between 35 -45mmHg and arterial oxygen saturation （ SaO2 ） was maintain 〉 88% by adjusting corresponding ventilator parameters. Ventilation period was 6h. Lung fluids were aspirated before and at the end of ventilation for cell analysis. Then the animals were euthanized, lung tissue was removed for wet/dry weight measurement, light and electron microscopic examination. Besults The difference of artery blood gas analyses（pH, PaO2, PaCO2 ） between HFOV and CMV was insignificant. The difference between HFOV and CMV in cytological examination of lung fluids, wet/dry weight measurement was also insignificant. But compared with CMV, HFOV not only reduced the area of lung injury, but also reduced lung injury score in light and electron microscopic examination. Conclusion When same artery blood gas analysis was obtained, HFOV significantly reduced lung injury development in ARDS animal than CMV. As a lung protection strategy, HFOV can be used in the treatment of ARDS.
基金supported by the National Natural Science Foundation of China(Grant Nos.91123018,61172041,61172040,50975226,and 60801022)the National Hi-Tech Research and Development Program of China("863"Project)(Grant No.2008AA03A314)the Fundamental Research Funds for the Central Universities
文摘Laser was coupled into an optical fiber,on which covered a layer of well-aligned carbon nanotubes(CNTs)serving as cathode,to tune the field emission of the cathode.CNT arrays as field emission cathode were synthesized by chemical vapor deposition(CVD)on a naked fiber core.When the laser was coupled into the fiber,the turn-on voltage(Vto at a current density of 1 mA cm?2)decreased from 1.0 to 0.9 kV and the emission current density increased from 0.83 mA cm?2(at a 1 kV bias voltage)to3.04 mA cm?2 on 40μm diameter fiber.A photon absorption mechanism is attributed to the field emission improvement.The estimated effective work function of CNT arrays on the optical fiber decrease from 4.89 to 4.29 eV.The results show the possibility of constructing a waveguide type laser modulated field emission cathode.
