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轻质烃类的气相色谱组成与相对密度定量关系研究
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作者 陈海燕 《科技情报开发与经济》 2006年第19期158-159,共2页
通过收集数据建立轻质烃类色谱组成与相对密度之间的多元线性回归方程,并对方程进行验证,实现由色谱组成计算相对密度的目的。
关键词 气相色谱组成 相对密度测定 轻质烃类
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Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components 被引量:16
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作者 Han-Lin Gong Wen-Fu Tang +5 位作者 Qin Yu Jin Xiang Qing xia Guang-Yuan Chen Xi Huang Mao-Zhi Liang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第47期5992-5999,共8页
AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control gro... AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group(n=6). Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax(chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023) and AUC(rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272)of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin(P=0.0467 and 0.0005,respectively)and Tmax of chrysophanol and rheochrysidin(P=0.0101 and 0.0037,respectively) lasted longer in SAP group than in control group. CONCLUSION:SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters. 展开更多
关键词 Severe acute pancreatitis Da-Cheng-Qi Decoction Pharmacokinetics Components
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