目的:探讨“益气清湿化瘀”法对慢性子宫内膜炎性不孕的疗效。方法:于2022年12月至2023年12月期间共纳入患者132例,其中来源于成都中医药大学附属医院60例,四川省第二中医医院36例,四川省人民医院温江医院36例,将以上患者随机按数字表法...目的:探讨“益气清湿化瘀”法对慢性子宫内膜炎性不孕的疗效。方法:于2022年12月至2023年12月期间共纳入患者132例,其中来源于成都中医药大学附属医院60例,四川省第二中医医院36例,四川省人民医院温江医院36例,将以上患者随机按数字表法以1:1分为对照组和观察组各66例。治疗组口服自拟盆炎康复汤、妇科灌肠液直肠给药联合口服盐酸多西环素,对照组口服妇科千金胶囊和盐酸多西环素,两组均治疗3个月,并随访半年。治疗结束后采用多模态超声评价患者子宫内膜容受性,并记录其治疗前后中医证候评分变化及月经改变,同时随访患者妊娠率及早期流产情况。结果:治疗组临床妊娠率29.03%,妊娠率38.70%,均高于对照组的13.11%与21.31% (P 0.05);治疗后治疗组的子宫内膜容受性的超声检查评分明显高于对照组;治疗组中医症候评分低于对照组(P Objective: To explore the efficacy of “supplementing qi, clearing dampness and removing stasis” on chronic endometritis infertility. Methods: From December 2022 to December 2023, a total of 132 patients were included, including 60 from the Hospital of Chengdu University of Traditional Chinese Medicine, 36 from the Second Hospital of Traditional Chinese Medicine of Sichuan Province, and 36 from Chengdu Wenjiang Hospital of Sichuan Provincial People’s Hospital. The above patients were randomly divided by 1:1 into the control group and 66 from the observation group according to the number table method. The treatment group received oral self-prepared pelvic inflammation rehabilitation soup, gynecological enema and rectal administration combined with oral doxycycline hydrochloride, and the control group took oral gynecological Qianjin capsule and doxycycline hydrochloride. Both groups were treated for 3 months and followed up for half a year. After the end of treatment, multimodal ultrasound was used to evaluate endometrial tolerance, and the changes of TCM syndrome score and menstrual changes before and after treatment were recorded, and the pregnancy rate and early abortion were followed up. Results: The clinical pregnancy rate in the treatment group was 29.03%, The pregnancy rate was 38.70%, Are higher than the control group of 13.11% % and 21.31% (P 0.05);the ultrasound score of endometrial receptivity in the treated group was significantly higher than that of the control group;TCM syndrome score in the treatment group than the control group (P < 0.05);the recovery rate of menstrual abnormalities, abnormal leucorrhea and pelvic pain after treatment was higher than the control group, statistically significant (P < 0.05). Conclusion: “Self-prepared pelvic inflammation rehabilitation soup, gynecological enema combined with doxycycline hydrochloride” is effective in improving endometrial receptivity of chronic endometritis infertility patients, regulating patients’ menstruation, improving TCM syndrome, and promoting fertility, which is worthy of gynecological clinical promotion and application.展开更多
目的:观察消白方结合西医常规疗法治疗脾肾气虚、湿热瘀阻型慢性肾小球肾炎(CGN)患者的临床疗效。方法:纳入120例脾肾气虚、湿热瘀阻型CGN患者[慢性肾脏病(CKD)1~2期],随机分为对照组和治疗组,每组各60例。对照组患者给予西医开放性方...目的:观察消白方结合西医常规疗法治疗脾肾气虚、湿热瘀阻型慢性肾小球肾炎(CGN)患者的临床疗效。方法:纳入120例脾肾气虚、湿热瘀阻型CGN患者[慢性肾脏病(CKD)1~2期],随机分为对照组和治疗组,每组各60例。对照组患者给予西医开放性方案治疗,治疗组患者在此基础上加用消白方口服,两组疗程均为6个月。评价两组患者的临床疗效及中医证候疗效,治疗前后检测所有患者的24 h尿蛋白定量(24 h UPro)、尿微量白蛋白/尿肌酐比值(UACR)、尿N-乙酰-β-D-葡萄糖苷酶(NAG)、尿视黄醇结合蛋白(RBP)、尿α1-微球蛋白(α1-MG)、尿β2-微球蛋白(β2-MG)及血清肌酐(Scr)和尿素氮(BUN)、肾小球滤过率估计值(eGFR)水平。结果:研究过程中,治疗组4例患者剔除或脱落,对照组5例患者剔除或脱落,最终治疗组56例、对照组55例患者纳入统计分析。(1)临床疗效:治疗后,治疗组患者的临床总有效率为92.9%,对照组为87.3%,治疗组的疗效优于对照组(P<0.05)。(2)中医证候疗效:治疗后,治疗组患者的中医证候疗效总有效率为89.3%,对照组为54.5%,治疗组的疗效优于对照组(P<0.01)。(3)实验室指标:治疗后,两组患者的24 h UPro、UACR、NAG、RBP水平较治疗前均明显降低(P<0.05),治疗组患者的α1-MG、β2-MG水平亦明显降低(P<0.05),且治疗组患者的24 h UPro、NAG、RBP、α1-MG、β2-MG水平低于对照组(P<0.05)。治疗后,治疗组患者的eGFR水平较治疗前明显升高(P<0.05)、Scr水平较治疗前明显降低(P<0.05),且治疗组患者的Scr水平低于对照组(P<0.05)。(4)相关性分析:eGFR与24 h UPro、UACR、NAG、RBP呈负相关。结论:消白方结合西医常规疗法治疗脾肾气虚、湿热瘀阻型CGN(CKD1~2期)患者,能有效改善患者的临床症状,降低尿蛋白水平,改善肾小管损伤相关指标,延缓肾功能进展。展开更多
文摘目的:探讨“益气清湿化瘀”法对慢性子宫内膜炎性不孕的疗效。方法:于2022年12月至2023年12月期间共纳入患者132例,其中来源于成都中医药大学附属医院60例,四川省第二中医医院36例,四川省人民医院温江医院36例,将以上患者随机按数字表法以1:1分为对照组和观察组各66例。治疗组口服自拟盆炎康复汤、妇科灌肠液直肠给药联合口服盐酸多西环素,对照组口服妇科千金胶囊和盐酸多西环素,两组均治疗3个月,并随访半年。治疗结束后采用多模态超声评价患者子宫内膜容受性,并记录其治疗前后中医证候评分变化及月经改变,同时随访患者妊娠率及早期流产情况。结果:治疗组临床妊娠率29.03%,妊娠率38.70%,均高于对照组的13.11%与21.31% (P 0.05);治疗后治疗组的子宫内膜容受性的超声检查评分明显高于对照组;治疗组中医症候评分低于对照组(P Objective: To explore the efficacy of “supplementing qi, clearing dampness and removing stasis” on chronic endometritis infertility. Methods: From December 2022 to December 2023, a total of 132 patients were included, including 60 from the Hospital of Chengdu University of Traditional Chinese Medicine, 36 from the Second Hospital of Traditional Chinese Medicine of Sichuan Province, and 36 from Chengdu Wenjiang Hospital of Sichuan Provincial People’s Hospital. The above patients were randomly divided by 1:1 into the control group and 66 from the observation group according to the number table method. The treatment group received oral self-prepared pelvic inflammation rehabilitation soup, gynecological enema and rectal administration combined with oral doxycycline hydrochloride, and the control group took oral gynecological Qianjin capsule and doxycycline hydrochloride. Both groups were treated for 3 months and followed up for half a year. After the end of treatment, multimodal ultrasound was used to evaluate endometrial tolerance, and the changes of TCM syndrome score and menstrual changes before and after treatment were recorded, and the pregnancy rate and early abortion were followed up. Results: The clinical pregnancy rate in the treatment group was 29.03%, The pregnancy rate was 38.70%, Are higher than the control group of 13.11% % and 21.31% (P 0.05);the ultrasound score of endometrial receptivity in the treated group was significantly higher than that of the control group;TCM syndrome score in the treatment group than the control group (P < 0.05);the recovery rate of menstrual abnormalities, abnormal leucorrhea and pelvic pain after treatment was higher than the control group, statistically significant (P < 0.05). Conclusion: “Self-prepared pelvic inflammation rehabilitation soup, gynecological enema combined with doxycycline hydrochloride” is effective in improving endometrial receptivity of chronic endometritis infertility patients, regulating patients’ menstruation, improving TCM syndrome, and promoting fertility, which is worthy of gynecological clinical promotion and application.
文摘目的:观察消白方结合西医常规疗法治疗脾肾气虚、湿热瘀阻型慢性肾小球肾炎(CGN)患者的临床疗效。方法:纳入120例脾肾气虚、湿热瘀阻型CGN患者[慢性肾脏病(CKD)1~2期],随机分为对照组和治疗组,每组各60例。对照组患者给予西医开放性方案治疗,治疗组患者在此基础上加用消白方口服,两组疗程均为6个月。评价两组患者的临床疗效及中医证候疗效,治疗前后检测所有患者的24 h尿蛋白定量(24 h UPro)、尿微量白蛋白/尿肌酐比值(UACR)、尿N-乙酰-β-D-葡萄糖苷酶(NAG)、尿视黄醇结合蛋白(RBP)、尿α1-微球蛋白(α1-MG)、尿β2-微球蛋白(β2-MG)及血清肌酐(Scr)和尿素氮(BUN)、肾小球滤过率估计值(eGFR)水平。结果:研究过程中,治疗组4例患者剔除或脱落,对照组5例患者剔除或脱落,最终治疗组56例、对照组55例患者纳入统计分析。(1)临床疗效:治疗后,治疗组患者的临床总有效率为92.9%,对照组为87.3%,治疗组的疗效优于对照组(P<0.05)。(2)中医证候疗效:治疗后,治疗组患者的中医证候疗效总有效率为89.3%,对照组为54.5%,治疗组的疗效优于对照组(P<0.01)。(3)实验室指标:治疗后,两组患者的24 h UPro、UACR、NAG、RBP水平较治疗前均明显降低(P<0.05),治疗组患者的α1-MG、β2-MG水平亦明显降低(P<0.05),且治疗组患者的24 h UPro、NAG、RBP、α1-MG、β2-MG水平低于对照组(P<0.05)。治疗后,治疗组患者的eGFR水平较治疗前明显升高(P<0.05)、Scr水平较治疗前明显降低(P<0.05),且治疗组患者的Scr水平低于对照组(P<0.05)。(4)相关性分析:eGFR与24 h UPro、UACR、NAG、RBP呈负相关。结论:消白方结合西医常规疗法治疗脾肾气虚、湿热瘀阻型CGN(CKD1~2期)患者,能有效改善患者的临床症状,降低尿蛋白水平,改善肾小管损伤相关指标,延缓肾功能进展。
