Objective To study the effect of fluvastatin on changes of serum C-reactive protein(CRP) and soluable intercellular adhesion molecule-1(sICAM-1),soluabe vas-cular cell adhesion molecule-1(sVCAM-1) contents in patients...Objective To study the effect of fluvastatin on changes of serum C-reactive protein(CRP) and soluable intercellular adhesion molecule-1(sICAM-1),soluabe vas-cular cell adhesion molecule-1(sVCAM-1) contents in patients with acute coronary syndrome(ACS). Methods 109 patients with ACS were randomly divided into fluvastatin-treated group(55 cases) and conventional therapy group (54 cases). The contents of serum CRP (with immunoturbidity method), sICAM-1,sVCAM-1 (with ELISA) were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM-1, sVCAM-1 were significantly higher in the patients with ACS than controls(P<0.01). ②After treatment,the levels of serum CRP, sICAM-1,sVCAM-1 in patients with fluvastatin decreased significantly(P<0.01), but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .展开更多
目的:探讨氟伐他丁对各级慢性心力衰竭患者心功能及C反应蛋白(CRP)的影响。方法:37例患者按美国纽约心脏学会(American New York Heart Academy,NYHA)分级分为心功能Ⅱ、Ⅲ、Ⅳ级组,所有患者在正规抗心力衰竭治疗基础上加用氟伐他丁40 m...目的:探讨氟伐他丁对各级慢性心力衰竭患者心功能及C反应蛋白(CRP)的影响。方法:37例患者按美国纽约心脏学会(American New York Heart Academy,NYHA)分级分为心功能Ⅱ、Ⅲ、Ⅳ级组,所有患者在正规抗心力衰竭治疗基础上加用氟伐他丁40 mg.d-1,连续口服10个月,在加用氟伐他丁治疗前后做心脏彩超检查,并测定CRP水平。结果:治疗10个月后,各级心力衰竭患者CRP水平较加药前下降,心功能有所改善。结论:氟伐他丁能降低炎症因子CRP水平,改善心功能,尤其对NYHAⅣ级心力衰竭患者心功能改善明显。展开更多
文摘Objective To study the effect of fluvastatin on changes of serum C-reactive protein(CRP) and soluable intercellular adhesion molecule-1(sICAM-1),soluabe vas-cular cell adhesion molecule-1(sVCAM-1) contents in patients with acute coronary syndrome(ACS). Methods 109 patients with ACS were randomly divided into fluvastatin-treated group(55 cases) and conventional therapy group (54 cases). The contents of serum CRP (with immunoturbidity method), sICAM-1,sVCAM-1 (with ELISA) were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM-1, sVCAM-1 were significantly higher in the patients with ACS than controls(P<0.01). ②After treatment,the levels of serum CRP, sICAM-1,sVCAM-1 in patients with fluvastatin decreased significantly(P<0.01), but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .
文摘目的:探讨氟伐他丁对各级慢性心力衰竭患者心功能及C反应蛋白(CRP)的影响。方法:37例患者按美国纽约心脏学会(American New York Heart Academy,NYHA)分级分为心功能Ⅱ、Ⅲ、Ⅳ级组,所有患者在正规抗心力衰竭治疗基础上加用氟伐他丁40 mg.d-1,连续口服10个月,在加用氟伐他丁治疗前后做心脏彩超检查,并测定CRP水平。结果:治疗10个月后,各级心力衰竭患者CRP水平较加药前下降,心功能有所改善。结论:氟伐他丁能降低炎症因子CRP水平,改善心功能,尤其对NYHAⅣ级心力衰竭患者心功能改善明显。
