The firing tests with clay blocks were undertaken to study thefluorine expulsion and retention char- acteristics of calcium-basedmaterials during the firing of brick clays. The results indicate thatfluorine expulsion ...The firing tests with clay blocks were undertaken to study thefluorine expulsion and retention char- acteristics of calcium-basedmaterials during the firing of brick clays. The results indicate thatfluorine expulsion begins at approx. 600-700 deg. C, and the mainportion occurs in 800-1000 deg. C. The mode of firing has someeffects on fluorine expulsion. Additives of calcium-based materialcan reduce fluorine expulsion, which is mainly attributed to theincreased formation of CaF_2 during clay firing. In addition, theoptimum addition tests of 6 calcium-based materials with higherefficiency were carried out in a brick kiln. More than 75/100fluorine is retained in the brick body and there is no adverse effecton brick product. This makes it possible for brickyard to achievenon-polluting production.展开更多
Objective： Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties but with favorable tolerability in humans. ＂Ibis analgesic also exhibits neuroprotective activities. Furthermore, flup...Objective： Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties but with favorable tolerability in humans. ＂Ibis analgesic also exhibits neuroprotective activities. Furthermore, flupirtine antagonizes glutamate- and . , 2＋ NMDA-mduced mtracellular levels of Ca and counteracts the effects of focal cerebral Lscherma. Although fluplrtme has been used to relieve pain caused by different diseases and clinical procedures, information on the safety and efficacy of flupirtine is limited. ＂fhe present study was conducted to investigate the neuroprotective effects of flupirtine on U373 malignant glioma （MG） cell lines. Methods： Cellviability and cell cycle analysis was performed by MTF assay and flow cytomet-,＇y, respectively. Results： Variations in the growth of U373 MG cells in $ mM N-methyl-D-aspartate （NMDA）, 1 mM flupirtine, and combined treatment indicated the antagonistic effects of NMDA and flupirtine on MG cell lines. The variation in the percentage of gated cellpopulation in different cell cycle phases showed significant variations after 48 h of treatment. Conclusion： Flupirtine has neuroprotective effect of on U373 MG cells, which limits its use in the pain management of brain tumors. This property warrants further studies using animal models and large-scale clinical trials.展开更多
文摘The firing tests with clay blocks were undertaken to study thefluorine expulsion and retention char- acteristics of calcium-basedmaterials during the firing of brick clays. The results indicate thatfluorine expulsion begins at approx. 600-700 deg. C, and the mainportion occurs in 800-1000 deg. C. The mode of firing has someeffects on fluorine expulsion. Additives of calcium-based materialcan reduce fluorine expulsion, which is mainly attributed to theincreased formation of CaF_2 during clay firing. In addition, theoptimum addition tests of 6 calcium-based materials with higherefficiency were carried out in a brick kiln. More than 75/100fluorine is retained in the brick body and there is no adverse effecton brick product. This makes it possible for brickyard to achievenon-polluting production.
基金supported by an intramural grant from Sri Ramachandra University,Chennai
文摘Objective： Flupirtine is a non-opioid analgesic without antipyretic or antiphlogistic properties but with favorable tolerability in humans. ＂Ibis analgesic also exhibits neuroprotective activities. Furthermore, flupirtine antagonizes glutamate- and . , 2＋ NMDA-mduced mtracellular levels of Ca and counteracts the effects of focal cerebral Lscherma. Although fluplrtme has been used to relieve pain caused by different diseases and clinical procedures, information on the safety and efficacy of flupirtine is limited. ＂fhe present study was conducted to investigate the neuroprotective effects of flupirtine on U373 malignant glioma （MG） cell lines. Methods： Cellviability and cell cycle analysis was performed by MTF assay and flow cytomet-,＇y, respectively. Results： Variations in the growth of U373 MG cells in $ mM N-methyl-D-aspartate （NMDA）, 1 mM flupirtine, and combined treatment indicated the antagonistic effects of NMDA and flupirtine on MG cell lines. The variation in the percentage of gated cellpopulation in different cell cycle phases showed significant variations after 48 h of treatment. Conclusion： Flupirtine has neuroprotective effect of on U373 MG cells, which limits its use in the pain management of brain tumors. This property warrants further studies using animal models and large-scale clinical trials.
