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家兔氟尿嘧啶胃左动脉灌注与静脉化疗药物动力学比较 被引量:2
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作者 申宝忠 杨光 尚鸣异 《介入放射学杂志》 CSCD 2002年第6期449-452,共4页
目的 评价氟尿嘧啶动物胃左动脉灌注和外周静脉化疗药物动力学的基础实验比较。方法 实验家兔 18只 ,随机分 6个时间组 ,由胃左动脉注入氟尿嘧啶 (按 5 0mg/kg) ,于不同时间点 ,留取门静脉及外周静脉血 ,同时处死动物 ,取部分胃组织... 目的 评价氟尿嘧啶动物胃左动脉灌注和外周静脉化疗药物动力学的基础实验比较。方法 实验家兔 18只 ,随机分 6个时间组 ,由胃左动脉注入氟尿嘧啶 (按 5 0mg/kg) ,于不同时间点 ,留取门静脉及外周静脉血 ,同时处死动物 ,取部分胃组织。血样及组织样经处理后采用高效液相色谱测定 ,对照组由耳缘静脉注入氟尿嘧啶 (5 0mg/kg) ,不同时间取血和组织 ,同上处理后测定。 结果 两种途径给药后的门静脉及外周静脉的药时曲线均为 5min达到高峰值 ,之后迅速下降 ,30min后下降缓慢 ,符合二室模型 ;动脉灌注组门静脉血药浓度明显高于外周血药浓度 ,亦明显高于静脉注药组的门静脉浓度 ,而且持续时间较长 ;5min后动脉灌注组胃组织药物浓度 11倍于静脉给药组 ,2h后两者浓度接近。结论 经胃左动脉灌注在门静脉及胃组织中的药物浓度在较长时间内维持相对高的水平 ,而且能使局部药物相对集中 。 展开更多
关键词 氟尿嘧定 药物动力学 化疗
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大肠癌术后早期5-Fu腹腔化疗的临床研究
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作者 王立义 侯国瑞 《基层医学论坛》 2003年第10期882-883,共2页
目的探讨大肠癌术后早期大剂量大容积5-Fu 腹腔化疗(IPC)的可行性和疗效。方法全组62例结、直肠癌患者,共接受 54疗程770次 IPC。化疗期间观察毒性反应、对肝功影响及并发症等。随访6~42个月,平均16个月。结果全组无严重毒副作用和并... 目的探讨大肠癌术后早期大剂量大容积5-Fu 腹腔化疗(IPC)的可行性和疗效。方法全组62例结、直肠癌患者,共接受 54疗程770次 IPC。化疗期间观察毒性反应、对肝功影响及并发症等。随访6~42个月,平均16个月。结果全组无严重毒副作用和并发症。随访结果与同期其它化疗方法差异有显著性(P<0.05)。结论 IPC 简便易行、安全,是结、直肠癌术后早期有前途的辅助化疗措施。 展开更多
关键词 结、直肠癌 5-氟尿嘧定 腹腔化疗
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Synthesis and stability evaluation of 5-FU-acetic podophyllic ester as anti-tumor agent
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作者 向蓉 张辅民 +1 位作者 倪京满 田瑄 《Journal of Chinese Pharmaceutical Sciences》 CAS 2007年第1期47-50,共4页
Aim To study a new anti-cancer drug 5-FU-acetic podophyllic ester derivatized from podophyllotoxin. Methods A novel derivative of podophyllotoxin was synthesized. Its inhibitory effects against P-388, A-549, Bel-7402 ... Aim To study a new anti-cancer drug 5-FU-acetic podophyllic ester derivatized from podophyllotoxin. Methods A novel derivative of podophyllotoxin was synthesized. Its inhibitory effects against P-388, A-549, Bel-7402 and HL-60 in vitro were tested. The stability tests under different kinds of conditions were carried out. Results The novel derivative showed stronger inhibitory activities against P-388, A-549 and Bel-7402 in vitro than VP-16. The novel derivative was found to be stable at 60 ℃ and 4500 1x light in solid-state, but was less stable in humid condition. It was more stable in methanol (4 ℃ ) and chloroform (25 ℃ ) than in methanol (25 ℃), and less stable in artificial gastric juice ( AGJ, 37 ℃ ). Its stabilities were decreased while increasing the pH of buffer solutions. Conclusion These results could provide useful information for further study of this compound. 展开更多
关键词 Podophyllotoxin 5-FLUOROURACIL Anti-tumor activity STABILITIES
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Increased sensitivity of colorectal cancer cell lines with microsatellite instability to 5-fluorouracil in vitro
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作者 陈修煦 来茂德 黄琼 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第7期1048-1052,151-152,共5页
OBJECTIVE: To study the relationship between sensitivity to 5-FU and the status of a panel of microsatellite loci in three human colon cancer cell lines. METHODS: Cell viability in several concentrations of 5-FU was a... OBJECTIVE: To study the relationship between sensitivity to 5-FU and the status of a panel of microsatellite loci in three human colon cancer cell lines. METHODS: Cell viability in several concentrations of 5-FU was assessed by the MTT test. Expression of hMSH2 and hMLH1 in LoVo, SW480 and SW1116 cells were analyzed by immunocytochemical staining.Ten mononucleotide and dinucleotide microsatellite loci were analyzed by the PCR-SSLP-silver staining method. RESULTS: By MTT assay, it showed that LoVo cells were more sensitive than SW480 and SW1116 cells (0.8 micromol/L,2.2 micromol/L and 1.9 micromol/L, respectively, P 展开更多
关键词 DNA-Binding Proteins Microsatellite Repeats Antimetabolites Antineoplastic Base Pair Mismatch Carrier Proteins Colorectal Neoplasms DNA Repair Fluorouracil Humans Immunohistochemistry MutS Homolog 2 Protein Neoplasm Proteins Nuclear Proteins Polymerase Chain Reaction Proto-Oncogene Proteins Tumor Cells Cultured
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