目的在围麻醉期和危重患者的通气中，高浓度氧吸入可引起肺泡不张，肺内分流率增加，长时间应用可引起肺实质损害。研究观察术后麻醉恢复期不同吸入氧浓度通气对拔管前氧储备和肺换气功能的影响，为通气选择合适的吸入氧浓度提供依据。...目的在围麻醉期和危重患者的通气中，高浓度氧吸入可引起肺泡不张，肺内分流率增加，长时间应用可引起肺实质损害。研究观察术后麻醉恢复期不同吸入氧浓度通气对拔管前氧储备和肺换气功能的影响，为通气选择合适的吸入氧浓度提供依据。方法152例不吸烟的全麻择期手术患者，进入麻醉恢复室（post anesthesia care unit，PACU）后接呼吸机，通气模式为同步间歇指令通气，调节吸入氧浓度为35％，进行肺活量膨肺的肺复原操作，操作结束后，呼吸机调回同步间歇指令通气模式。根据完全随机的原则分为4组（每组38例）：0．35吸入氧浓度（fraction of inspired oxygen in nitrogen，FiO2）组，0．50FiO2组，0．75FiO2组，1．0FiO2组。通气5min，停止通气。当血氧饱和度下降至90％，接上呼吸机。穿刺抽取足背动脉血，并根据公式计算肺内分流率（Qs／Qt）和氧合指数（PaO2/FiO2）。结果0．35FiO2组0．50Fi02组，0．75FiO2组和1．0FiO2组的无通气时限分别为（129±42）、（178±61）、（340±152）、（421±153）S（P〈0．001）。1．0FiO2组的无通气时限高于0．75F102组，但差异无统计学意义。1．0FiO2组的无通气时限明显高于0．35FiO2组和0．50FiO2组（P〈0．005）；0．75FiO2组的无通气时限非常明显高于0．35F1O2组和0．50FiO2组（P〈0．005）。0．50FiO2组的无通气时限高于0．35F1O2组，但差异无统计学意义。0．35FiO2组0．50FiO2组，0．75FiO2组的肺内分流率分别为（4．1±1．1）、（4．6±1．3）、（5．1±2．5）％，均明显低于1．0FiO2组（13．1±4．5）％（P〈0．001）。0．35FiO2组，0．50FiO2组和0．75FiO2组氧合指数分别为（494±75）、（523±70）、（536±80），明显高于1．0FiO2组（423±94，P〈0．005）。结论吸人0．75的氧能够改善肺换气功能，但无通气时限减少。展开更多
As one of the most promising next-generation energy storage devices,the lithium-metal battery has been extensively investigated.However,safety issues and undesired lithium dendrite growth hinder its development.The ap...As one of the most promising next-generation energy storage devices,the lithium-metal battery has been extensively investigated.However,safety issues and undesired lithium dendrite growth hinder its development.The application of solid-state electrolytes has attracted increasing attention as they can solve safety issues and show great potential to inhibit the growth of lithium dendrites.Polyethylene oxide(PEO)-based electrolytes are very promising due to their enhanced safety and excellent flexibility.However,they suffer from low ionic conductivity at room temperature and cannot effectively inhibit lithium dendrites at high temperatures due to the intrinsic semicrystalline properties and poor mechanical strength.In this work,a novel coral-like Li_(6.25)Al_(0.25)La_(3)Zr_(2)O_(12)(C-LALZO)is synthesized to serve as an active ceramic filler in PEO.The PEO with LALZO coral(PLC)exhibits increased ionic conductivity and mechanical strength,which leads to uniform deposition/stripping of lithium metal.The Li symmetric cells with PLC do not cause a short circuit after cycling for 1500 h at 60℃.The assembled LiFePO_(4)/PLC/Li batteries display excellent cycling stability at both 60 and 50℃.This work reveals that the electrochemical properties of the composite electrolyte can be effectively improved by tuning the microstructure of the filler,such as the C-LALZO architecture.展开更多
文摘目的在围麻醉期和危重患者的通气中，高浓度氧吸入可引起肺泡不张，肺内分流率增加，长时间应用可引起肺实质损害。研究观察术后麻醉恢复期不同吸入氧浓度通气对拔管前氧储备和肺换气功能的影响，为通气选择合适的吸入氧浓度提供依据。方法152例不吸烟的全麻择期手术患者，进入麻醉恢复室（post anesthesia care unit，PACU）后接呼吸机，通气模式为同步间歇指令通气，调节吸入氧浓度为35％，进行肺活量膨肺的肺复原操作，操作结束后，呼吸机调回同步间歇指令通气模式。根据完全随机的原则分为4组（每组38例）：0．35吸入氧浓度（fraction of inspired oxygen in nitrogen，FiO2）组，0．50FiO2组，0．75FiO2组，1．0FiO2组。通气5min，停止通气。当血氧饱和度下降至90％，接上呼吸机。穿刺抽取足背动脉血，并根据公式计算肺内分流率（Qs／Qt）和氧合指数（PaO2/FiO2）。结果0．35FiO2组0．50Fi02组，0．75FiO2组和1．0FiO2组的无通气时限分别为（129±42）、（178±61）、（340±152）、（421±153）S（P〈0．001）。1．0FiO2组的无通气时限高于0．75F102组，但差异无统计学意义。1．0FiO2组的无通气时限明显高于0．35FiO2组和0．50FiO2组（P〈0．005）；0．75FiO2组的无通气时限非常明显高于0．35F1O2组和0．50FiO2组（P〈0．005）。0．50FiO2组的无通气时限高于0．35F1O2组，但差异无统计学意义。0．35FiO2组0．50FiO2组，0．75FiO2组的肺内分流率分别为（4．1±1．1）、（4．6±1．3）、（5．1±2．5）％，均明显低于1．0FiO2组（13．1±4．5）％（P〈0．001）。0．35FiO2组，0．50FiO2组和0．75FiO2组氧合指数分别为（494±75）、（523±70）、（536±80），明显高于1．0FiO2组（423±94，P〈0．005）。结论吸人0．75的氧能够改善肺换气功能，但无通气时限减少。
基金supported by the School Research Startup Expenses of Harbin Institute of Technology(Shenzhen)(DD29100027)the National Natural Science Foundation of China(52002094)+2 种基金China Postdoctoral Science Foundation(2019M661276)Guangdong Basic and AppliedBasic Research Foundation(2019A1515110756)the High-level Talents Discipline Construction Fund of Shandong University(31370089963078)。
文摘As one of the most promising next-generation energy storage devices,the lithium-metal battery has been extensively investigated.However,safety issues and undesired lithium dendrite growth hinder its development.The application of solid-state electrolytes has attracted increasing attention as they can solve safety issues and show great potential to inhibit the growth of lithium dendrites.Polyethylene oxide(PEO)-based electrolytes are very promising due to their enhanced safety and excellent flexibility.However,they suffer from low ionic conductivity at room temperature and cannot effectively inhibit lithium dendrites at high temperatures due to the intrinsic semicrystalline properties and poor mechanical strength.In this work,a novel coral-like Li_(6.25)Al_(0.25)La_(3)Zr_(2)O_(12)(C-LALZO)is synthesized to serve as an active ceramic filler in PEO.The PEO with LALZO coral(PLC)exhibits increased ionic conductivity and mechanical strength,which leads to uniform deposition/stripping of lithium metal.The Li symmetric cells with PLC do not cause a short circuit after cycling for 1500 h at 60℃.The assembled LiFePO_(4)/PLC/Li batteries display excellent cycling stability at both 60 and 50℃.This work reveals that the electrochemical properties of the composite electrolyte can be effectively improved by tuning the microstructure of the filler,such as the C-LALZO architecture.
