Background: Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first-line treatment for acne vulgaris (AV). However, these combinations could have a suboptimal s...Background: Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first-line treatment for acne vulgaris (AV). However, these combinations could have a suboptimal skin tolerability. Recently, a new formulation of hydrogen peroxide (HP) 1%in stabilized cream (Crystacide.; Mipharm,Milan, Italy) became available. A previous clinical study has shown that HP cream monotherapy presents a better skin tolerability in comparison with BP in patients with mild AV. Objectives: To evaluate the tolerability and the efficacy of combination therapy with HP cream and adapalene 0.1%gel in comparison with the combination of BP 4%cream and adapalene 0.1%gel in the treatment of mild to moderate AV. Methods: In a randomized, investigator-blinded trial, 52 patients (mean ±SD age 25 ±6 years; 19 men and 33 women) with AV were randomly assigned to HP cream and adapalene gel (group HP +A) or to BP cream and adapalene gel (group BP +A), for eight consecutive weeks. Efficacy was assessed by total (TL), inflammatory (IL) and noninflammatory (NL) lesion counts performed at baseline and weeks 4 and 8. Tolerability was assessed by evaluating skin erythema, burning and dryness at weeks 4 and 8. Results: All patients completed the study. At baseline, the mean ±SD numbers of TL, IL and NL were 44 ±9, 25 ±7 and 19 ±6 in group HP +A and 40 ±9, 21 ±7 and 19 ±9 in group BP +A, respectively. At the end of the treatment period, TL, IL and NL were reduced by 93%, 92%and 95%, respectively, in groupHP +A and by 88%, 86%and 90%, respectively, in group BP +A. A significantly (P = 0.0025) greater reduction in NL was observed in group HP +A in comparison with group BP +A. Tolerability was significantly better in group HP +A in comparison with group BP+A (P = 0.02). Skin dryness and burning sensation were more frequent in group BP +A. Conclusions: The combination of adapalene and HP cream is an effective topical treatment regimen in mild to moderate AV. This combination has shown a better tolerability profile in comparison with the combination of BP and adapalene.展开更多
文摘Background: Combination therapy with antiseptics such as benzoyl peroxide (BP) and topical retinoids is widely used as first-line treatment for acne vulgaris (AV). However, these combinations could have a suboptimal skin tolerability. Recently, a new formulation of hydrogen peroxide (HP) 1%in stabilized cream (Crystacide.; Mipharm,Milan, Italy) became available. A previous clinical study has shown that HP cream monotherapy presents a better skin tolerability in comparison with BP in patients with mild AV. Objectives: To evaluate the tolerability and the efficacy of combination therapy with HP cream and adapalene 0.1%gel in comparison with the combination of BP 4%cream and adapalene 0.1%gel in the treatment of mild to moderate AV. Methods: In a randomized, investigator-blinded trial, 52 patients (mean ±SD age 25 ±6 years; 19 men and 33 women) with AV were randomly assigned to HP cream and adapalene gel (group HP +A) or to BP cream and adapalene gel (group BP +A), for eight consecutive weeks. Efficacy was assessed by total (TL), inflammatory (IL) and noninflammatory (NL) lesion counts performed at baseline and weeks 4 and 8. Tolerability was assessed by evaluating skin erythema, burning and dryness at weeks 4 and 8. Results: All patients completed the study. At baseline, the mean ±SD numbers of TL, IL and NL were 44 ±9, 25 ±7 and 19 ±6 in group HP +A and 40 ±9, 21 ±7 and 19 ±9 in group BP +A, respectively. At the end of the treatment period, TL, IL and NL were reduced by 93%, 92%and 95%, respectively, in groupHP +A and by 88%, 86%and 90%, respectively, in group BP +A. A significantly (P = 0.0025) greater reduction in NL was observed in group HP +A in comparison with group BP +A. Tolerability was significantly better in group HP +A in comparison with group BP+A (P = 0.02). Skin dryness and burning sensation were more frequent in group BP +A. Conclusions: The combination of adapalene and HP cream is an effective topical treatment regimen in mild to moderate AV. This combination has shown a better tolerability profile in comparison with the combination of BP and adapalene.
