目的:探讨动静脉二氧化碳分压差/氧含量差在预测重症肺炎并呼吸衰竭患者预后中的应用价值。方法:选取170例本院重症监护室2020年7月至2022年7月收治的患者,根据疾病类型不同分为重症肺炎并呼吸衰竭组(n=62)、单纯重症肺炎组(n=60)、单...目的:探讨动静脉二氧化碳分压差/氧含量差在预测重症肺炎并呼吸衰竭患者预后中的应用价值。方法:选取170例本院重症监护室2020年7月至2022年7月收治的患者,根据疾病类型不同分为重症肺炎并呼吸衰竭组(n=62)、单纯重症肺炎组(n=60)、单纯呼吸衰竭组(n=48)。比较各组间及重症肺炎并呼吸衰竭组不同预后患者的动静脉二氧化碳分压差及动静脉二氧化碳分压差/氧含量差及对患者预后的预测效能。结果:三组间动静脉二氧化碳分压差及动静脉二氧化碳分压差/氧含量差比较,重症肺炎并呼吸衰竭组最高,其次为单纯重症肺炎组,最后为单纯呼吸衰竭组(P<0.05)。重症肺炎并呼吸衰竭组中死亡组动静脉二氧化碳分压差及动静脉二氧化碳分压差/氧含量差均明显高于存活组(P<0.05),动静脉二氧化碳分压差/氧含量差对重症肺炎并呼吸衰竭组患者预后进行预测的受试者工作特征曲线(Receiver operating characteristic curve,ROC曲线)下的面积(Area under the curve,AUC)、灵敏度、特异度依次为0.888,77.8%,90.9%。结论:重症肺炎并呼吸衰竭患者中动静脉二氧化碳分压差/氧含量差均呈现高水平表达,通过观察其表达水平可对患者预后进行有效预测。展开更多
A SiC/ZrSiO4？SiO2 （SZS） coating was successfully fabricated on the carbon/carbon （C/C） composites by pack cementation, slurry painting and sintering to improve the anti-oxidation property and thermal shock r...A SiC/ZrSiO4？SiO2 （SZS） coating was successfully fabricated on the carbon/carbon （C/C） composites by pack cementation, slurry painting and sintering to improve the anti-oxidation property and thermal shock resistance. The anti-oxidation properties under different oxygen partial pressures （OPP） and thermal shock resistance of the SZS coating were investigated. The results show that the SZS coated sample under low OPP, corresponding to the ambient air, during isothermal oxidation was 0.54% in mass gain after 111 h oxidation at 1500 ° C and less than 0.03% in mass loss after 50 h oxidation in high OPP, corresponding to the air flow rate of 36 L/h. Additionally, the residual compressive strengths （RCS） of the SZS coated samples after oxidation for 50 h in high OPP and 80 h in low OPP remain about 70% and 72.5% of those of original C/C samples, respectively. Moreover, the mass loss of SZS coated samples subjected to the thermal cycle from 1500 ° C in high OPP to boiling water for 30 times was merely 1.61%.展开更多
目的研究中心静脉动脉二氧化碳分压差/氧含量差的比值(Pcv-aCO_(2)/Ca-cvO_(2))、中心静脉血氧饱和度(ScvO_(2))、乳酸(Lac)联合预测感染性休克患者预后的价值。方法选择2017年5月—2020年4月期间河北北方学院附属第一医院收治的感染性...目的研究中心静脉动脉二氧化碳分压差/氧含量差的比值(Pcv-aCO_(2)/Ca-cvO_(2))、中心静脉血氧饱和度(ScvO_(2))、乳酸(Lac)联合预测感染性休克患者预后的价值。方法选择2017年5月—2020年4月期间河北北方学院附属第一医院收治的感染性休克患者进行回顾性研究,液体复苏前检测0 h Pcv-aCO_(2)/Ca-cvO_(2)、0 h Sc⁃vO_(2)、0 h Lac,液体复苏后6 h检测6 h Pcv-aCO_(2)/Ca-cvO_(2)、6 h ScvO_(2)、6 h Lac并计算0~6 h Pcv-aCO_(2)/CacvO 2变化率、0~6 h ScvO_(2)变化率、0~6 h Lac清除率(LCR)。采用28 d存活或死亡作为评价预后的指标,采用Logistic回归模型生成联合预测指标的方程,采用ROC曲线分析不同指标对预后的预测价值。结果与存活的感染性休克患者比较,死亡患者的0 h Lac、0 h ScvO_(2)无明显变化,0 h Pcv-aCO_(2)/Ca-cvO_(2)、6 h Pcv-aCO_(2)/CacvO 2、6 h Lac明显增加,0~6 h Pcv-aCO_(2)/Ca-cvO_(2)变化率、6 h ScvO_(2)、0~6 h ScvO_(2)变化率、0~6 h LCR明显降低;经ROC曲线分析,0 h Pcv-aCO_(2)/Ca-cvO_(2)、6 h Pcv-aCO_(2)/Ca-cvO_(2)、0~6 h Pcv-aCO_(2)/Ca-cvO_(2)变化率、6 h Sc⁃vO_(2)、0~6 h ScvO_(2)变化率、6 h Lac、0~6 h LCR对预后具有预测价值;0~6 h Pcv-aCO_(2)/Ca-cvO_(2)变化率、0~6 h Sc⁃vO_(2)变化率、0~6 h LCR联合预测感染性休克患者预后的新指标,对预后具有预测价值且预测价值优于单一指标。结论复苏后6 h Pcv-aCO_(2)/Ca-cvO_(2)及ScvO_(2)变化率、LCR联合预测感染性休克患者的预后,联合指标的预测价值均优于单一指标。展开更多
AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2)...AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immuno-fluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAP/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, PGG induced Nrf2 nuclear translocation, which was found to be an upstream step of PGG-induced HO-1 expression, and ERK activation, of which pathway was involved in PGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION: PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-depen-dent manner, and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects.展开更多
AIM： To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde （MDA, an indicator of oxidative stress） and nonenzymic antioxidants in...AIM： To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde （MDA, an indicator of oxidative stress） and nonenzymic antioxidants in children with acute hepatitis A. METHODS： Whole blood MDA and reduced glutathione （GSH）, serum β-carotene, retinol, vitamin E and vitamin C levels were studied in 19 （10 females, 9 males） children with acute hepatitis A and in 29 （β females, 16 males） healthy control subjects. RESULTS： There was a statistically significant difference between patients and controls for all parameters （P 〈 0.05）. Lipid peroxidation marker MDA was significantly elevated （P 〈 0.001）, while antioxidants β-carotene, retinol and GSH were significantly decreased （all P 〈 0.001） in patients compared to healthy subjects. In addition, o-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls （P 〈 0.05, P 〈 0.01, respectively）. CONCLUSION： Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A.展开更多
Using the orthogonal experimental design method involving three factors and three levels, the flexural strength and the compressive strength of copolymer grouting material were studied with different compositions of w...Using the orthogonal experimental design method involving three factors and three levels, the flexural strength and the compressive strength of copolymer grouting material were studied with different compositions of water-cement ratio （mass fraction of water to cement）, epoxy resin content, and waterborne epoxy curing agent content. By orthogonal range and variance analysis, the orders of three factors to influence the strength, the significance levels of different factors, and the optimized compound ratio scheme of copolymer grouting material mixture at different curing ages were determined. An empirical relationship among the strength of copolymer grouting material, the water-cement ratio, the epoxy resin content, and the waterborne epoxy curing agent content was established by multivariate regression analysis. The results indicate that water-cement ratio is the most principal and significant influencing factor on the strength. Epoxy resin content and waterbome epoxy curing agent content also have a significant influence on the strength. But epoxy resin content has a greater influence on the 7-day and 28-day flexural strength, and waterborne epoxy curing agent content has a greater influence on the 3-day flexural strength and the compressive strength. The copolymer grouting material with water-cement ratio of 0.4, epoxy resin content of 8% （mass fraction） and waterbome epoxy curing agent content of 2% （mass fraction） is the best one for repairing of cement concrete pavement. The flexural strength and the compressive strength have good correlation, and the ratio of compressive strength to flexural strength is between 1.0 and 3.3.展开更多
Graphite oxide(GO) was prepared by the pressurized oxidation method and incorporated into polyimide(PI) matrix to fabricate high-k composite films by in-situ polymerization and subsequent thermal treatment. The result...Graphite oxide(GO) was prepared by the pressurized oxidation method and incorporated into polyimide(PI) matrix to fabricate high-k composite films by in-situ polymerization and subsequent thermal treatment. The results show that the as-prepared GO had good dispersion and compatibility in PI matrix due to the introduction of abundant oxygen-containing functional groups during the oxidation. The residual graphitic domains and the thermal treatment induced reduction of GO further enhanced the dielectric permittivity of the resulting GO–PI composites. The dielectric permittivity of the GO–PI composites exhibited a typical percolation behavior with a percolation threshold of 0.0347 of volume ratio and a critical exponent of 0.837. Near the percolation threshold, the dielectric permittivity of the GO–PI composite increased to 108 at 10~2 Hz and was 26 times that of the pure PI.展开更多
Achillea millefolium （Asteraceae） is a permanent herb highly recognized in traditional medicine for its anti-oxidant and anti-inflammation properties. However, studies on phytochemical constituents of A. millefoli...Achillea millefolium （Asteraceae） is a permanent herb highly recognized in traditional medicine for its anti-oxidant and anti-inflammation properties. However, studies on phytochemical constituents of A. millefolium underlying these properties are scarce. The present work focuses on examining the effect of methanol extract of A. millefolium L. on total and differential blood cells account on albino male mice. The results showed the methanol extract increased the account of lymphocyte, and monocyte cells, and total account as well as this extract showed high decrease in the oxidative stress of MTX after the interfere between the extract and MTX due to increase in the leucocyte cells compared with controls. Concluded from these results that methanol extract of A. millefolium has ability enhancement in leucocyte cells in the blood and it has detoxification effect of MTX.展开更多
文摘目的:探讨动静脉二氧化碳分压差/氧含量差在预测重症肺炎并呼吸衰竭患者预后中的应用价值。方法:选取170例本院重症监护室2020年7月至2022年7月收治的患者,根据疾病类型不同分为重症肺炎并呼吸衰竭组(n=62)、单纯重症肺炎组(n=60)、单纯呼吸衰竭组(n=48)。比较各组间及重症肺炎并呼吸衰竭组不同预后患者的动静脉二氧化碳分压差及动静脉二氧化碳分压差/氧含量差及对患者预后的预测效能。结果:三组间动静脉二氧化碳分压差及动静脉二氧化碳分压差/氧含量差比较,重症肺炎并呼吸衰竭组最高,其次为单纯重症肺炎组,最后为单纯呼吸衰竭组(P<0.05)。重症肺炎并呼吸衰竭组中死亡组动静脉二氧化碳分压差及动静脉二氧化碳分压差/氧含量差均明显高于存活组(P<0.05),动静脉二氧化碳分压差/氧含量差对重症肺炎并呼吸衰竭组患者预后进行预测的受试者工作特征曲线(Receiver operating characteristic curve,ROC曲线)下的面积(Area under the curve,AUC)、灵敏度、特异度依次为0.888,77.8%,90.9%。结论:重症肺炎并呼吸衰竭患者中动静脉二氧化碳分压差/氧含量差均呈现高水平表达,通过观察其表达水平可对患者预后进行有效预测。
基金Project supported by the Nonferrous Metal Oriented Advanced Structural Materials and Manufacturing Cooperative Innovation Center,ChinaProject(51205417)supported by the National Natural Science Foundation of China
文摘A SiC/ZrSiO4？SiO2 （SZS） coating was successfully fabricated on the carbon/carbon （C/C） composites by pack cementation, slurry painting and sintering to improve the anti-oxidation property and thermal shock resistance. The anti-oxidation properties under different oxygen partial pressures （OPP） and thermal shock resistance of the SZS coating were investigated. The results show that the SZS coated sample under low OPP, corresponding to the ambient air, during isothermal oxidation was 0.54% in mass gain after 111 h oxidation at 1500 ° C and less than 0.03% in mass loss after 50 h oxidation in high OPP, corresponding to the air flow rate of 36 L/h. Additionally, the residual compressive strengths （RCS） of the SZS coated samples after oxidation for 50 h in high OPP and 80 h in low OPP remain about 70% and 72.5% of those of original C/C samples, respectively. Moreover, the mass loss of SZS coated samples subjected to the thermal cycle from 1500 ° C in high OPP to boiling water for 30 times was merely 1.61%.
文摘目的研究中心静脉动脉二氧化碳分压差/氧含量差的比值(Pcv-aCO_(2)/Ca-cvO_(2))、中心静脉血氧饱和度(ScvO_(2))、乳酸(Lac)联合预测感染性休克患者预后的价值。方法选择2017年5月—2020年4月期间河北北方学院附属第一医院收治的感染性休克患者进行回顾性研究,液体复苏前检测0 h Pcv-aCO_(2)/Ca-cvO_(2)、0 h Sc⁃vO_(2)、0 h Lac,液体复苏后6 h检测6 h Pcv-aCO_(2)/Ca-cvO_(2)、6 h ScvO_(2)、6 h Lac并计算0~6 h Pcv-aCO_(2)/CacvO 2变化率、0~6 h ScvO_(2)变化率、0~6 h Lac清除率(LCR)。采用28 d存活或死亡作为评价预后的指标,采用Logistic回归模型生成联合预测指标的方程,采用ROC曲线分析不同指标对预后的预测价值。结果与存活的感染性休克患者比较,死亡患者的0 h Lac、0 h ScvO_(2)无明显变化,0 h Pcv-aCO_(2)/Ca-cvO_(2)、6 h Pcv-aCO_(2)/CacvO 2、6 h Lac明显增加,0~6 h Pcv-aCO_(2)/Ca-cvO_(2)变化率、6 h ScvO_(2)、0~6 h ScvO_(2)变化率、0~6 h LCR明显降低;经ROC曲线分析,0 h Pcv-aCO_(2)/Ca-cvO_(2)、6 h Pcv-aCO_(2)/Ca-cvO_(2)、0~6 h Pcv-aCO_(2)/Ca-cvO_(2)变化率、6 h Sc⁃vO_(2)、0~6 h ScvO_(2)变化率、6 h Lac、0~6 h LCR对预后具有预测价值;0~6 h Pcv-aCO_(2)/Ca-cvO_(2)变化率、0~6 h Sc⁃vO_(2)变化率、0~6 h LCR联合预测感染性休克患者预后的新指标,对预后具有预测价值且预测价值优于单一指标。结论复苏后6 h Pcv-aCO_(2)/Ca-cvO_(2)及ScvO_(2)变化率、LCR联合预测感染性休克患者的预后,联合指标的预测价值均优于单一指标。
基金Supported by the Korean Research Foundation Grant(KRF-2004-005-200038)
文摘AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immuno-fluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAP/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, PGG induced Nrf2 nuclear translocation, which was found to be an upstream step of PGG-induced HO-1 expression, and ERK activation, of which pathway was involved in PGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION: PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-depen-dent manner, and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects.
文摘AIM： To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde （MDA, an indicator of oxidative stress） and nonenzymic antioxidants in children with acute hepatitis A. METHODS： Whole blood MDA and reduced glutathione （GSH）, serum β-carotene, retinol, vitamin E and vitamin C levels were studied in 19 （10 females, 9 males） children with acute hepatitis A and in 29 （β females, 16 males） healthy control subjects. RESULTS： There was a statistically significant difference between patients and controls for all parameters （P 〈 0.05）. Lipid peroxidation marker MDA was significantly elevated （P 〈 0.001）, while antioxidants β-carotene, retinol and GSH were significantly decreased （all P 〈 0.001） in patients compared to healthy subjects. In addition, o-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls （P 〈 0.05, P 〈 0.01, respectively）. CONCLUSION： Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A.
基金Projects(40728003, 40772180, 40802064) supported by the National Natural Science Foundation of ChinaProject (07JJ4012) supported by the Hunan Provincial Natural Science Foundation of China+1 种基金project (20080430680) supported by China Postdoctoral Science FoundationProject(B308) supported by Shanghai Leading Academic Discipline Project
文摘Using the orthogonal experimental design method involving three factors and three levels, the flexural strength and the compressive strength of copolymer grouting material were studied with different compositions of water-cement ratio （mass fraction of water to cement）, epoxy resin content, and waterborne epoxy curing agent content. By orthogonal range and variance analysis, the orders of three factors to influence the strength, the significance levels of different factors, and the optimized compound ratio scheme of copolymer grouting material mixture at different curing ages were determined. An empirical relationship among the strength of copolymer grouting material, the water-cement ratio, the epoxy resin content, and the waterborne epoxy curing agent content was established by multivariate regression analysis. The results indicate that water-cement ratio is the most principal and significant influencing factor on the strength. Epoxy resin content and waterbome epoxy curing agent content also have a significant influence on the strength. But epoxy resin content has a greater influence on the 7-day and 28-day flexural strength, and waterborne epoxy curing agent content has a greater influence on the 3-day flexural strength and the compressive strength. The copolymer grouting material with water-cement ratio of 0.4, epoxy resin content of 8% （mass fraction） and waterbome epoxy curing agent content of 2% （mass fraction） is the best one for repairing of cement concrete pavement. The flexural strength and the compressive strength have good correlation, and the ratio of compressive strength to flexural strength is between 1.0 and 3.3.
基金Project(2013JSJJ002)supported by the Faculty Research Fund of Central South University,China
文摘Graphite oxide(GO) was prepared by the pressurized oxidation method and incorporated into polyimide(PI) matrix to fabricate high-k composite films by in-situ polymerization and subsequent thermal treatment. The results show that the as-prepared GO had good dispersion and compatibility in PI matrix due to the introduction of abundant oxygen-containing functional groups during the oxidation. The residual graphitic domains and the thermal treatment induced reduction of GO further enhanced the dielectric permittivity of the resulting GO–PI composites. The dielectric permittivity of the GO–PI composites exhibited a typical percolation behavior with a percolation threshold of 0.0347 of volume ratio and a critical exponent of 0.837. Near the percolation threshold, the dielectric permittivity of the GO–PI composite increased to 108 at 10~2 Hz and was 26 times that of the pure PI.
文摘Achillea millefolium （Asteraceae） is a permanent herb highly recognized in traditional medicine for its anti-oxidant and anti-inflammation properties. However, studies on phytochemical constituents of A. millefolium underlying these properties are scarce. The present work focuses on examining the effect of methanol extract of A. millefolium L. on total and differential blood cells account on albino male mice. The results showed the methanol extract increased the account of lymphocyte, and monocyte cells, and total account as well as this extract showed high decrease in the oxidative stress of MTX after the interfere between the extract and MTX due to increase in the leucocyte cells compared with controls. Concluded from these results that methanol extract of A. millefolium has ability enhancement in leucocyte cells in the blood and it has detoxification effect of MTX.
文摘目的探讨动静脉二氧化碳分压差/氧含量差[P(v-a)CO2/C(a-v)O2]在早期重症急性胰腺炎(severe acute pancreatitis,SAP)患者中的预后评估价值.方法自2017年8月至2018年10月连续性纳入78例SAP患者,根据患者治疗后P(v-a)CO2/C(a-v)O2是否上升分为两组,研究组(上升组,n=32例)和对照组(下降组,n=46例).比较两组一般临床资料,病程中器官功能障碍并发症发生率、临床预后及氧代谢指标,并评估氧代谢指标对患者的预测价值.结果研究组病情危重度、CT评分、胰腺坏死范围及APACHEⅡ评分明显高于对照组(P<0.05);同时病程中研究组休克、急性呼吸窘迫综合征、急性肾损伤、胰腺坏死组织感染(IPN)等并发症发生率明显高于对照组(P<0.05).且与对照组比较,研究组IPN发生更早、ICU及住院天数更长、病死率更高(P<0.05).治疗前两组P(v-a)CO2/C(a-v)O2差异无统计学意义,但研究组治疗后P(v-a)CO2/C(a-v)O2(mm Hg/mL:2.51±1.37 vs.1.91±1.29,P=0.031)以及治疗前后P(v-a)CO2和乳酸明显高于对照组(P<0.05).多因素Logistics回归分析发现,治疗前患者住院死亡危险因素为P(v-a)CO2(P=0.017)及血乳酸(P=0.021),治疗后为P(v-a)CO2(P=0.009)、P(v-a)CO2/C(a-v)O2(P=0.019)及血乳酸(P=0.023).ROC曲线提示,治疗前P(v-a)CO2对SAP死亡预测价值最高,曲线下面积为0.762,最佳诊断界值为7.69 mm Hg;治疗后P(v-a)CO2/C(a-v)O2对SAP死亡预测价值最高,曲线下面积为0.840,最佳诊断界值为2.05 mm Hg/mL.结论P(v-a)CO2/C(a-v)O2在早期SAP患者预后评估中具有良好的临床应用价值,值得临床推广.
