特发性矮小症（Idiopathic short stature,ISS）是导致儿童身材矮小的最常见原因,占矮小症的60%-80%[1]。ISS是指没有明确病因的匀称性身材矮小,即身高低于同年龄、同性别儿童均值的2个标准差（-2SD）或第3百分位以下,出生身长及体质量...特发性矮小症（Idiopathic short stature,ISS）是导致儿童身材矮小的最常见原因,占矮小症的60%-80%[1]。ISS是指没有明确病因的匀称性身材矮小,即身高低于同年龄、同性别儿童均值的2个标准差（-2SD）或第3百分位以下,出生身长及体质量均正常,出生后生长速率（Growth velocity,GV）缓慢,外周血生长激素（Growth hormone,GH）激发峰值≥10μg/L,其他实验室检查无异常发现，并排除宫内发育迟缓、营养不良、各系统组织的器质性疾病、遗传代谢及染色体疾病等已知病因者。展开更多
Background: Crohn’ s disease (CD) is characterized, among other features, by intestinal malabsorption of miner als, vitamins,and various food ingredients. This may cause a suboptimal peak bone mass and thereby suscep...Background: Crohn’ s disease (CD) is characterized, among other features, by intestinal malabsorption of miner als, vitamins,and various food ingredients. This may cause a suboptimal peak bone mass and thereby susceptibility to osteoporosis at an early age. Objective: Longitudinal measurement of bone in CD during active disease and during remissi on. Design: We evaluated 24 patients with CD (16 males) 14 to 16 years of age lo ngitudinally, every 3 months over 12 months, for disease activity. Longitudinal follow- up by quantitative ultrasound measurement using a bone sonometer (Sunli ght Omnisense, Tel Aviv, Israel) that obtains axial speed of sound (SOS) was als o performed. Eight of the CD patients were in remission (R- CD), characterized by accelerated weight and height gain and near- normal erythrocyte sedimentatio n rate and serum iron. Eight patients had active CD(A- CD), and 8 patients were under treatment with oxandrolone. Results: By two- way repeated- measures ana lysis of variance, the change in SOS Z- score of tibia at 0, 6, and 12 months w as as follows: - 0.5 ± 0.2 to - 0.3 ± 0.2, - 0.6 ± 0.2 to - 1.0 ± 0. 5 and - 0.6 ± 0.2 to - 0.4 ± 0.2 in the remission, active disease, and oxa ndrolone- treated groups, respectively (P < 0.001). Similarly, the change in SO S Z- score of radius during the study was as follows: - 0.5 ± 0.3 to - 0.6 ± 0.3, - 0.6 ± 0.3 to - 1.0 ± 0.3 and - 0.6 ± 0.2 to - 0.4 ± 0.2 i n the remission, active disease, and oxandrolone- treated groups, respectively (P < 0.001). While a small change over time in patients in remission was noted, SOS decreased in patients with active disease and increased in oxandrolone- tre ated patients. Despite the fact that SOS remained in the normative range in all patients, a clear deterioration was demonstrated for patients with active diseas e. Conclusions: We conclude that longitudinal follow- up of patients with activ e disease may detect an early pattern of deterioration in quality of bone.展开更多
文摘特发性矮小症（Idiopathic short stature,ISS）是导致儿童身材矮小的最常见原因,占矮小症的60%-80%[1]。ISS是指没有明确病因的匀称性身材矮小,即身高低于同年龄、同性别儿童均值的2个标准差（-2SD）或第3百分位以下,出生身长及体质量均正常,出生后生长速率（Growth velocity,GV）缓慢,外周血生长激素（Growth hormone,GH）激发峰值≥10μg/L,其他实验室检查无异常发现，并排除宫内发育迟缓、营养不良、各系统组织的器质性疾病、遗传代谢及染色体疾病等已知病因者。
文摘Background: Crohn’ s disease (CD) is characterized, among other features, by intestinal malabsorption of miner als, vitamins,and various food ingredients. This may cause a suboptimal peak bone mass and thereby susceptibility to osteoporosis at an early age. Objective: Longitudinal measurement of bone in CD during active disease and during remissi on. Design: We evaluated 24 patients with CD (16 males) 14 to 16 years of age lo ngitudinally, every 3 months over 12 months, for disease activity. Longitudinal follow- up by quantitative ultrasound measurement using a bone sonometer (Sunli ght Omnisense, Tel Aviv, Israel) that obtains axial speed of sound (SOS) was als o performed. Eight of the CD patients were in remission (R- CD), characterized by accelerated weight and height gain and near- normal erythrocyte sedimentatio n rate and serum iron. Eight patients had active CD(A- CD), and 8 patients were under treatment with oxandrolone. Results: By two- way repeated- measures ana lysis of variance, the change in SOS Z- score of tibia at 0, 6, and 12 months w as as follows: - 0.5 ± 0.2 to - 0.3 ± 0.2, - 0.6 ± 0.2 to - 1.0 ± 0. 5 and - 0.6 ± 0.2 to - 0.4 ± 0.2 in the remission, active disease, and oxa ndrolone- treated groups, respectively (P < 0.001). Similarly, the change in SO S Z- score of radius during the study was as follows: - 0.5 ± 0.3 to - 0.6 ± 0.3, - 0.6 ± 0.3 to - 1.0 ± 0.3 and - 0.6 ± 0.2 to - 0.4 ± 0.2 i n the remission, active disease, and oxandrolone- treated groups, respectively (P < 0.001). While a small change over time in patients in remission was noted, SOS decreased in patients with active disease and increased in oxandrolone- tre ated patients. Despite the fact that SOS remained in the normative range in all patients, a clear deterioration was demonstrated for patients with active diseas e. Conclusions: We conclude that longitudinal follow- up of patients with activ e disease may detect an early pattern of deterioration in quality of bone.
