In order to explain the special antibiotic activity of urine, various chromatographic techniques were applied to separate and purify the key component from the healthy male urine. The structure of purified component w...In order to explain the special antibiotic activity of urine, various chromatographic techniques were applied to separate and purify the key component from the healthy male urine. The structure of purified component was identified by mass spectrometry and NMR. The results indicated that the substance separated from the male urine was trimethoprim. This is the first report of trimethoprim separated from urine.展开更多
The Cu（Ⅱ）complexes of 2-aminopyrimidine were synthesized and characterized by elemental analyses,TG-DTG.The dissolution enthalpies of the[AP（s）+CuCl2·2H2O（s）]and Cu（AP） Cl2（s）in 100.00 mL 2 mol.L-1HCl ...The Cu（Ⅱ）complexes of 2-aminopyrimidine were synthesized and characterized by elemental analyses,TG-DTG.The dissolution enthalpies of the[AP（s）+CuCl2·2H2O（s）]and Cu（AP） Cl2（s）in 100.00 mL 2 mol.L-1HCl solution were measured at 298.15 K by classical solution calorimetry.The standard molar reaction enthalpy of the coondination reaction of 2-aminopyrimidine with Cu（Ⅱ）has been determined by a thermochemical cycle(ΔrH<sup>○-m=-1.92±0.27kJ·mol-1).From the result,the standard molar enthalpy of formation ΔfH<sup>○-m[Cu（AP）Cl2,s,298.15K] of Cu（AP）Cl2 has been calculated to be-297.46±1.72kJ·mol-1.展开更多
Synthesis steps of 4,5 diamino 6 hydroxy 2 mercaptopyrimidine were improved on cyclocondensation of ethyl cyanoacetate with thiourea,nitrosation and reduction to obtain the product in 89% yield with high purity on ind...Synthesis steps of 4,5 diamino 6 hydroxy 2 mercaptopyrimidine were improved on cyclocondensation of ethyl cyanoacetate with thiourea,nitrosation and reduction to obtain the product in 89% yield with high purity on industrial scale.展开更多
文摘In order to explain the special antibiotic activity of urine, various chromatographic techniques were applied to separate and purify the key component from the healthy male urine. The structure of purified component was identified by mass spectrometry and NMR. The results indicated that the substance separated from the male urine was trimethoprim. This is the first report of trimethoprim separated from urine.
文摘The Cu（Ⅱ）complexes of 2-aminopyrimidine were synthesized and characterized by elemental analyses,TG-DTG.The dissolution enthalpies of the[AP（s）+CuCl2·2H2O（s）]and Cu（AP） Cl2（s）in 100.00 mL 2 mol.L-1HCl solution were measured at 298.15 K by classical solution calorimetry.The standard molar reaction enthalpy of the coondination reaction of 2-aminopyrimidine with Cu（Ⅱ）has been determined by a thermochemical cycle(ΔrH<sup>○-m=-1.92±0.27kJ·mol-1).From the result,the standard molar enthalpy of formation ΔfH<sup>○-m[Cu（AP）Cl2,s,298.15K] of Cu（AP）Cl2 has been calculated to be-297.46±1.72kJ·mol-1.
文摘Synthesis steps of 4,5 diamino 6 hydroxy 2 mercaptopyrimidine were improved on cyclocondensation of ethyl cyanoacetate with thiourea,nitrosation and reduction to obtain the product in 89% yield with high purity on industrial scale.
