酰胺合成的研究进展

酰胺官能团是自然界中最基本的化学结构单元之一,并且广泛存在于精细化学品结构中。目前,合成酰胺的方法已被国内外所报道,包括羧酸与胺的偶联反应、醛和胺的缩合反应、以芳基卤化物和胺和CO为底物的氨基羰基化反应。随着环保的理念深入人心,酰胺的制备也逐渐趋于绿色、环保的合成方法。本文从原料的角度综述了各种合成酰胺的方法。

Enantioselective synthesis of β-amino esters bearing a quinazoline moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative

The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess （up to 99%）.