Aim To develop a concise method for the synthesis of bicyclic azasugar and thiosugar with novel scaffold. Methods The two primary hydroxyl groups of compound 1 were selectively protected with tosyl cloloride in pyridi...Aim To develop a concise method for the synthesis of bicyclic azasugar and thiosugar with novel scaffold. Methods The two primary hydroxyl groups of compound 1 were selectively protected with tosyl cloloride in pyridine, followed by ring-closure with sodium sulfide or primary amine to form the oxy-bridged bicyclic molecules in good yields. Results Two bicyclic azasugars and a thiosugar were produced from L-sorbose in several steps. Conclusion The described procedures provide an efficient method to synthesize bicyclic azasugar and thiosugar with novel scaffold as potential glycosidase inhibitors.展开更多
Removal of SO2 and NOx by pulsed corona combined with in situ alkali absorption was experimentally investigated.In the reactor,a plate-wire-plate combination is devised for generating pulsed corona and then alkaline a...Removal of SO2 and NOx by pulsed corona combined with in situ alkali absorption was experimentally investigated.In the reactor,a plate-wire-plate combination is devised for generating pulsed corona and then alkaline absorbent slurries were introduced into the reactor by a continuous band conveying system to capture the gaseous reaction products.It was found that both SO2 and NO could be removed by corona combined with in situ alkali absorption.The removal of SO2 increased to 75%with the corona discharge,compared with 60%removal only with Ca(OH)2 absorption.About 40%removal of NO was reached by pulsed corona combined with in situ Ca(OH)2 absorption.It was found that SO2 and NO in the gas stream are oxidized to SO3 and NO2 by pulsed corona respectively,and then absorbed by the alkali in the reactor.The removals of SO2 as well as NO were higher with Ca(OH)2 as the absorbent,compared with using CaCO3 or ZnO.展开更多
基金We thank the National Science Foundation of China(NSFC,N0.20372003)for financial support.
文摘Aim To develop a concise method for the synthesis of bicyclic azasugar and thiosugar with novel scaffold. Methods The two primary hydroxyl groups of compound 1 were selectively protected with tosyl cloloride in pyridine, followed by ring-closure with sodium sulfide or primary amine to form the oxy-bridged bicyclic molecules in good yields. Results Two bicyclic azasugars and a thiosugar were produced from L-sorbose in several steps. Conclusion The described procedures provide an efficient method to synthesize bicyclic azasugar and thiosugar with novel scaffold as potential glycosidase inhibitors.
基金Supported by the Science and Technology Development Project of Zhejiang Province(2007C13085)Hangzhou City(20070733B28)
文摘Removal of SO2 and NOx by pulsed corona combined with in situ alkali absorption was experimentally investigated.In the reactor,a plate-wire-plate combination is devised for generating pulsed corona and then alkaline absorbent slurries were introduced into the reactor by a continuous band conveying system to capture the gaseous reaction products.It was found that both SO2 and NO could be removed by corona combined with in situ alkali absorption.The removal of SO2 increased to 75%with the corona discharge,compared with 60%removal only with Ca(OH)2 absorption.About 40%removal of NO was reached by pulsed corona combined with in situ Ca(OH)2 absorption.It was found that SO2 and NO in the gas stream are oxidized to SO3 and NO2 by pulsed corona respectively,and then absorbed by the alkali in the reactor.The removals of SO2 as well as NO were higher with Ca(OH)2 as the absorbent,compared with using CaCO3 or ZnO.
