Composite biomaterials with controllable mi- crostructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructu...Composite biomaterials with controllable mi- crostructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructure fabricated by assembly of iron oxide nanopartides during the gelation process in the presence of rotating magnetic field. It should be mentioned that the iron oxide nanoparticles here were synthesized identically following techniques of Fer- umoxytol that is the only inorganic nanodrug approved by FDA for clinical applications. The microstructure of nano- particles inside the hydrogel was ordered three-dimensionally due to the twist of the aligned chains of magnetic nano- particles which leads to the lowest state of systematic energy. The size of microstructure can be tuned from several micro- meters to tens of micrometers by changing the assembly parameters. With the increase of microstructure size, the magnetothermal anisotropy was also augmented. This result confirmed that the assembly-induced anisotropy can occur even for the several micron aggregates of nanopartides. The rotating magnetic field-assisted technique is cost-effective, simple and flexible for the fabrication of composite hydrogel with ordered microstructure. We believe it will be favorable for the quick, green and intelligent fabrication of some com- posite materials.展开更多
基金supported by the National Key Research and Development Program of China(2017YFA0104301)the Fundamental Research Funds for the Central Universitiesthe supports from Collaborative Innovation Center of Suzhou Nano Science and Technology
文摘Composite biomaterials with controllable mi- crostructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructure fabricated by assembly of iron oxide nanopartides during the gelation process in the presence of rotating magnetic field. It should be mentioned that the iron oxide nanoparticles here were synthesized identically following techniques of Fer- umoxytol that is the only inorganic nanodrug approved by FDA for clinical applications. The microstructure of nano- particles inside the hydrogel was ordered three-dimensionally due to the twist of the aligned chains of magnetic nano- particles which leads to the lowest state of systematic energy. The size of microstructure can be tuned from several micro- meters to tens of micrometers by changing the assembly parameters. With the increase of microstructure size, the magnetothermal anisotropy was also augmented. This result confirmed that the assembly-induced anisotropy can occur even for the several micron aggregates of nanopartides. The rotating magnetic field-assisted technique is cost-effective, simple and flexible for the fabrication of composite hydrogel with ordered microstructure. We believe it will be favorable for the quick, green and intelligent fabrication of some com- posite materials.
