The ultra-stable zeolite DASY-0.0 was prepared by hydrothermal method in commercial scale. Its structure was further modified via the treatment for cleaning of pores （CP）. The zeolite samples before and after CP tre...The ultra-stable zeolite DASY-0.0 was prepared by hydrothermal method in commercial scale. Its structure was further modified via the treatment for cleaning of pores （CP）. The zeolite samples before and after CP treating were analyzed and characterized by XRF, XRD, NMR, IR, BET and DTA. The results showed that, in comparison with the conventional ultra-stable zeolite DASY-0.0 prepared by the hydrothermal process, the CP-modified zeolite SOY0 exhibited a higher relative crystallinity, a larger surface area and pore volume, a higher thermal stability and contained less amorohous non-framework A1.展开更多
The Hedgehog （Hh） signaling pathway plays important roles in developmental processes including pattern formation and tissue homeostasis. The seven-pass transmembrane receptor Smoothened （Smo） is the pivotal transd...The Hedgehog （Hh） signaling pathway plays important roles in developmental processes including pattern formation and tissue homeostasis. The seven-pass transmembrane receptor Smoothened （Smo） is the pivotal transducer in the pathway; it, and thus the pathway overall, is regulated by ubiquitin-mediated degradation, which occurs in the absence of Hh. In the presence of Hh, the ubiquitination levels of Smo are decreased, but the molecular basis for this outcome is not well understood. Here, we identify the deubiquitinase UCHL5 as a positive regulator of the Hh pathway. We provide both genetic and biochemical evidence that UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane. Strikingly, we find that Hh enhances the interaction between UCHL5 and Smo, thereby stabilizing Smo. We also find that proteasome subunit RPN13, an activator of UCHL5, could enhance the effect of UCHL5 on Smo protein level. More importantly, we find that the mammalian counterpart of UCHL5, UCH37, plays the same role in the regulation of Hh signaling by modulating hSmo ubiquitination and stability. Our findings thus identify UCHL5/UCH37 as a critical regulator of Hh signaling and potential therapeutic target for cancers.展开更多
A new 2D Eu-BTB framework(1) with stratified gridding structure of about 14.6×16.9was synthesized and characterized.Compound 1 displays excellent water stability with the pH 2–12. The luminescent investigations ...A new 2D Eu-BTB framework(1) with stratified gridding structure of about 14.6×16.9was synthesized and characterized.Compound 1 displays excellent water stability with the pH 2–12. The luminescent investigations suggest that 1 could represent a chemical sensor of PO43. with high sensitivity and selectivity. Importantly, 1 as a sensor of PO_4^(3-) can be reused at least five times.On the other hand, the catalytic investigations of 1 were carried out, indicating that 1 could be demonstrated as a recyclable catalyst for CO_2 conversion with epoxides.展开更多
文摘The ultra-stable zeolite DASY-0.0 was prepared by hydrothermal method in commercial scale. Its structure was further modified via the treatment for cleaning of pores （CP）. The zeolite samples before and after CP treating were analyzed and characterized by XRF, XRD, NMR, IR, BET and DTA. The results showed that, in comparison with the conventional ultra-stable zeolite DASY-0.0 prepared by the hydrothermal process, the CP-modified zeolite SOY0 exhibited a higher relative crystallinity, a larger surface area and pore volume, a higher thermal stability and contained less amorohous non-framework A1.
基金This work was supported by grants from the National Basic Research Program of China （2011CB943902）, the National Natural Science Foundation of China （30971679, 31071264, and 31271531）, and the Fundamental Research Funds for the Central Universities （090314380019）.
文摘The Hedgehog （Hh） signaling pathway plays important roles in developmental processes including pattern formation and tissue homeostasis. The seven-pass transmembrane receptor Smoothened （Smo） is the pivotal transducer in the pathway; it, and thus the pathway overall, is regulated by ubiquitin-mediated degradation, which occurs in the absence of Hh. In the presence of Hh, the ubiquitination levels of Smo are decreased, but the molecular basis for this outcome is not well understood. Here, we identify the deubiquitinase UCHL5 as a positive regulator of the Hh pathway. We provide both genetic and biochemical evidence that UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane. Strikingly, we find that Hh enhances the interaction between UCHL5 and Smo, thereby stabilizing Smo. We also find that proteasome subunit RPN13, an activator of UCHL5, could enhance the effect of UCHL5 on Smo protein level. More importantly, we find that the mammalian counterpart of UCHL5, UCH37, plays the same role in the regulation of Hh signaling by modulating hSmo ubiquitination and stability. Our findings thus identify UCHL5/UCH37 as a critical regulator of Hh signaling and potential therapeutic target for cancers.
基金supported by the National Natural Science Foundation of China (21571123, 21571107, 21421001)the Natural Science Foundation of Tianjin (15JCZDJC37700)+1 种基金111 Project (B12015)MOE Innovation Team (IRT13022, IRT-13R30) of China
文摘A new 2D Eu-BTB framework(1) with stratified gridding structure of about 14.6×16.9was synthesized and characterized.Compound 1 displays excellent water stability with the pH 2–12. The luminescent investigations suggest that 1 could represent a chemical sensor of PO43. with high sensitivity and selectivity. Importantly, 1 as a sensor of PO_4^(3-) can be reused at least five times.On the other hand, the catalytic investigations of 1 were carried out, indicating that 1 could be demonstrated as a recyclable catalyst for CO_2 conversion with epoxides.
