Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expa...Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expansive soil is caused by the swell-shrinking.The stress is defined as "moisture-change stress" and is adopted to analyze swell-shrinkage deformation based on the elasticity mechanics theory.The state when the total stress becomes equal to the soil tensile strength is considered as the cracking criterion as moisture-change increases.Then,the initial cracking mechanism due to evaporation is revealed as follows:Different rates of moisture loss at different depths result in greater shrinkage deformation on the surface while there is smaller shrinkage deformation at the underlayer in expansive soil;cracks will grow when the nonuniform shrinkage deformation increases to a certain degree.A theoretical model is established,which may be used to calculate the stress caused by moisture-change.The depth of initial cracks growing is predicted by the proposed model in expansive soil,A series of laboratory tests are carried out by exposing expansive soil samples with different moisture-changes.The process of crack propagation is investigated by resistivity method.The test results show good consistency with the predicted results by the proposed theoretical model.展开更多
Currently,deformations along the central axis of specimens were usually measured under fixed environmental conditions. Seldom were the effects of environmental factors on the drying-shrinkage deformation of cement-bas...Currently,deformations along the central axis of specimens were usually measured under fixed environmental conditions. Seldom were the effects of environmental factors on the drying-shrinkage deformation of cement-based ma-terial considered. For this paper,the drying-shrinkage deformation at different w/b ratios and different additions to mor-tars was investigated under different environments at a temperature of 20 ℃ and humidity ranging from 100% to 50%. The specimens were cured in water for 28 days before measurement. The results illustrate that mortar shows much less shrinkage under various drying conditions when a lower w/b ratio is adopted. With a decrease in relative humidity the speed of drying-shrinkage becomes gradually lower. The addition of silica fume reduces the drying-shrinkage of mortar under higher relative humidity,because the pore structure of mortar with silica fume becomes more refined. The addi-tion of fly ash increases the total porosity and the volume of coarse pores in the mortar. The drying-shrinkage of mortar under different conditions increases with the addition of more of fly ash.展开更多
AIM： To evaluate the role of nitric oxide （NO） in the motor disorders of the dilated uninflamed mid-colon （DUMC） from trinitrobenzene sulfonic acid （TNBS）-induced acute distal colitis in rats. METHODS： Colitis...AIM： To evaluate the role of nitric oxide （NO） in the motor disorders of the dilated uninflamed mid-colon （DUMC） from trinitrobenzene sulfonic acid （TNBS）-induced acute distal colitis in rats. METHODS： Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration. Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase （MPO） and nitric oxide synthase （NOS） activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-L- arginine （L-NNA）. Pharmacological characterization of electric field stimulation （EFS）-evoked contractile responses was also performed. RESULTS： In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity. Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats. Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachyldnergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls. CONCLUSION： The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. 2005 The WJG Press and Elsevier Inc. All rights reserved展开更多
Glacier variations in the Tibetan Plateau and surrounding mountain ranges in China affect the livelihood of over one billion people who depend on water from the Yellow, Yangtze, Brahmaputra, Ganges and Indus rivers or...Glacier variations in the Tibetan Plateau and surrounding mountain ranges in China affect the livelihood of over one billion people who depend on water from the Yellow, Yangtze, Brahmaputra, Ganges and Indus rivers originating in these areas. Based on the results of the present study and published literature, we found that the glaciers shrank ：5.7% in area from 1963 to 20：0 with an annual area change of -0.33%. The shrinkage generally decreased from peripheral mountain ranges to the interior of Tibet. The linear trends of annual air temperature and precipitation at 147 stations were 0.36℃（10a）^-1 and 8.96 mm （10a）^-1 respectively from 1961 to 2010. The shrinkage of glaciers was well correlated with the rising temperature and the spatial patterns of the shrinkage were influenced by other factors superimposed on the rising temperature such as glacier size, type, elevation, debris cover and precipitation.展开更多
基金Project(2006BAB04A10) supported by the National Science and Technology Pillar Program during the 11th Five Year Plan of ChinaProject(51008117) supported by the National Natural Science Foundation of China
文摘Swelling and shrinkage due to moisture-change is one of the characteristics of the expansive soil,which is similar to the behavior of most materials under thermal effect,If the deformation is restricted,stress in expansive soil is caused by the swell-shrinking.The stress is defined as "moisture-change stress" and is adopted to analyze swell-shrinkage deformation based on the elasticity mechanics theory.The state when the total stress becomes equal to the soil tensile strength is considered as the cracking criterion as moisture-change increases.Then,the initial cracking mechanism due to evaporation is revealed as follows:Different rates of moisture loss at different depths result in greater shrinkage deformation on the surface while there is smaller shrinkage deformation at the underlayer in expansive soil;cracks will grow when the nonuniform shrinkage deformation increases to a certain degree.A theoretical model is established,which may be used to calculate the stress caused by moisture-change.The depth of initial cracks growing is predicted by the proposed model in expansive soil,A series of laboratory tests are carried out by exposing expansive soil samples with different moisture-changes.The process of crack propagation is investigated by resistivity method.The test results show good consistency with the predicted results by the proposed theoretical model.
基金Projects 2005AA332010 supported by the State High Technology Development Program (863) of China50408016 by the National Natural Science Foundation of China.
文摘Currently,deformations along the central axis of specimens were usually measured under fixed environmental conditions. Seldom were the effects of environmental factors on the drying-shrinkage deformation of cement-based ma-terial considered. For this paper,the drying-shrinkage deformation at different w/b ratios and different additions to mor-tars was investigated under different environments at a temperature of 20 ℃ and humidity ranging from 100% to 50%. The specimens were cured in water for 28 days before measurement. The results illustrate that mortar shows much less shrinkage under various drying conditions when a lower w/b ratio is adopted. With a decrease in relative humidity the speed of drying-shrinkage becomes gradually lower. The addition of silica fume reduces the drying-shrinkage of mortar under higher relative humidity,because the pore structure of mortar with silica fume becomes more refined. The addi-tion of fly ash increases the total porosity and the volume of coarse pores in the mortar. The drying-shrinkage of mortar under different conditions increases with the addition of more of fly ash.
文摘AIM： To evaluate the role of nitric oxide （NO） in the motor disorders of the dilated uninflamed mid-colon （DUMC） from trinitrobenzene sulfonic acid （TNBS）-induced acute distal colitis in rats. METHODS： Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS. Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration. Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase （MPO） and nitric oxide synthase （NOS） activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-L- arginine （L-NNA）. Pharmacological characterization of electric field stimulation （EFS）-evoked contractile responses was also performed. RESULTS： In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity. Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats. Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachyldnergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls. CONCLUSION： The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. 2005 The WJG Press and Elsevier Inc. All rights reserved
基金supported by the National Science Foundation of China (Grant Nos. 40871057 and 41271024)CAAS Project Innovation (2016-2020)+1 种基金IARRP (2016-637-1)Tianjin Philosophy and Social Science Planning Project (TJGL15-028)
文摘Glacier variations in the Tibetan Plateau and surrounding mountain ranges in China affect the livelihood of over one billion people who depend on water from the Yellow, Yangtze, Brahmaputra, Ganges and Indus rivers originating in these areas. Based on the results of the present study and published literature, we found that the glaciers shrank ：5.7% in area from 1963 to 20：0 with an annual area change of -0.33%. The shrinkage generally decreased from peripheral mountain ranges to the interior of Tibet. The linear trends of annual air temperature and precipitation at 147 stations were 0.36℃（10a）^-1 and 8.96 mm （10a）^-1 respectively from 1961 to 2010. The shrinkage of glaciers was well correlated with the rising temperature and the spatial patterns of the shrinkage were influenced by other factors superimposed on the rising temperature such as glacier size, type, elevation, debris cover and precipitation.
