In order to improve the early-age cracking resistance of concrete, different types of superplasticizers are used. Two types of polycarboxlic salt/acid superplasticizers and one retarding naphthalene superplasticizer a...In order to improve the early-age cracking resistance of concrete, different types of superplasticizers are used. Two types of polycarboxlic salt/acid superplasticizers and one retarding naphthalene superplasticizer are selected to investigate the influence of superplasticizers on the early-age cracking resistance of the concrete by using the slab test and the temperature-stress test. The results show that the polycarboxlic salt/acid superplasticizer cannot always improve the cracking resistance capacity of the concrete compared with the naphthalene superplasticizer, which is related to the chemical structure of the polycarboxlic salt/acid superplasticizer. High plastic tensile strength and dynamic elastic modulus at the early stage are beneficial to avoid cracking, and low hydration heat is also helpful. The evolutions of the drying shrilakage stress and the hydration heat temperature stress varying with time can be comprehensively evaluated by means of the slab test and the temperature stress test.展开更多
To minimize negative effects of geostress distribution on mining safety near the fault areas, the UPM40 triaxial geostress testing system was introduced to conduct in-situ geostress measurements at three sites and nin...To minimize negative effects of geostress distribution on mining safety near the fault areas, the UPM40 triaxial geostress testing system was introduced to conduct in-situ geostress measurements at three sites and nine points by the borehole stress-relief method. The results of strain?confining pressure curves show that rock masses at the three measuring sites exhibit comprehensive linear elasticity in spite of various fissures or cracks within rocks. Horizontal and vertical stress components distribute discrepantly near the fault areas, and the maximum lateral pressure coefficient is as high as 6.15. The maximum principle stress ranges from 8.01 to 14.93 MPa, and stress directions are in the range of N78.07°W?N17.55°W. Geostresses near fault areas are dominated by the horizontal tectonic stresses, while the lower values, compared to those under similar geological conditions are due to stress release by the fault. Additionally, the fault and shear stress nearby are partially responsible for asymmetric elongation and southwesterly migration of orebodies.展开更多
Based on the concept of stiffness degradation, a damage index of the whole frame and the storey is proposed for the frame seismic performance evaluation. The index is compatible with the non-linear static analysis (e...Based on the concept of stiffness degradation, a damage index of the whole frame and the storey is proposed for the frame seismic performance evaluation. The index is compatible with the non-linear static analysis (e. g. the pushover analysis), and the structural damage is considered via plastic hinges. Simultaneously, a practical approach is developed to obtain the relationships between the proposed index and earthquake intensities based on the capacity spectrum method. The proposed index is then illustrated through two low-rise reinforced concrete frames, and it is also compared with some other indices. The results indicate that the proposed index is on the safe side and not sensitive to the lateral load pattern. The storey index is helpful to reflect the storey damage and to uncover the position of the weak storey. Finally, the relationship between performance levels and damage index values is also proposed through statistical analysis for the performance-based seismic evaluation.展开更多
A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts.The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal ...A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts.The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal and oblique impacts.A square-root correction for neck bases was modified in accuracy as well as scope of applications.In addition,process of jet formation and evolution was studied to reveal internal dynamics in drop impacts.It's found that pressure gradient and vortex are coexisting and completive reasons for jet topology while the inclined angle has a significant effect on them.Mechanisms of jet formation and evolution are different in the front and back necks.With the help of PDF distribution and correction calculation,a compromise in the competition is observed.This work lays a solid foundation for further studies of dynamics in gas-liquid flows.展开更多
Ground stress is the fundamental cause of deformation and failure during underground structural engineering. Field stress measurements in the main coal bed in the Lueliang mining area were made by the bore hole, stres...Ground stress is the fundamental cause of deformation and failure during underground structural engineering. Field stress measurements in the main coal bed in the Lueliang mining area were made by the bore hole, stress relief method. From these data the ground stress distribution of the mining area was obtained. The relationship between the horizontal principal stress and the deformation and failure of a roadway is discussed with an engineering example. The results indicate that horizontal stress dominates in the shallow crust in the Ltiliang mining area. Roadways at different angles to the maximum principal stress have different levels of stress concentration. This leads to a significant difference in stability of the corresponding roadways. These research results provide an important criterion for determining roadway position and direction, stope layout, and roadway support design.展开更多
Computational fluid dynamics is an efficient numerical approach for spray atomization study, but it is challenging to accurately capture the gas-liquid interface. In this work, an accurate conservative level set metho...Computational fluid dynamics is an efficient numerical approach for spray atomization study, but it is challenging to accurately capture the gas-liquid interface. In this work, an accurate conservative level set method is intro- duced to accurately track the gas-liquid interfaces in liquid atomization. To validate the capability of this method, binary drop collision and drop impacting on liquid film are investigated. The results are in good agreement with experiment observations. In addition, primary atomization (swirling sheet atomization) is studied using this method. To the swirling sheet atomization, it is found that Rayleigh-Taylor instability in the azimuthal direction causes the primary breakup of liquid sheet and complex vortex structures are clustered around the rim of the liq- uid sheet. The effects of central gas velocity and liquid-gas density ratio on atomization are also investigated. This work lays a solid foundation for further studvin~ the mechanism of s^rav atomization.展开更多
The state of deep mine rigid shaft fUrniture horizontal force calculation in China is introduced and the calculating model of horizontal force is determined. Based on the interaction between hoisting vessel and shaft ...The state of deep mine rigid shaft fUrniture horizontal force calculation in China is introduced and the calculating model of horizontal force is determined. Based on the interaction between hoisting vessel and shaft furniture, the vertical mobel test device is built and a large number of model tests and analyses are carried out. At last, the relationship between horizontal force and hoisting end load, hoisting speed or bunton level interval is gained. The three parameters horizontal force calculating equation of beep mine rigid shaft furniture is given and it can guide the design and calculation of shaft engineering.展开更多
Objective:To find out how to overcome resistance during multiple myeloma(MM) treatment through establishing a multidrug resistant human multiple myeloma cell line and investigating its biological features.Methods:The ...Objective:To find out how to overcome resistance during multiple myeloma(MM) treatment through establishing a multidrug resistant human multiple myeloma cell line and investigating its biological features.Methods:The parent cell line MOLP-2 was exposed to different concentrations of melphalan and a melphalan-resistant cell line MOLP-2/R was identified by continuous stepwise selection.The cell morphology and growth curves were examined.Protein levels of P-gp, MRP and FANCD2 monoubiquitination were checked by Western blotting.The IC50 of melphalan and resistance index(RI) were detected by MTT assay.Results:A melphalan-resistant cell line MOLP-2/R was finally identified.The RI of MOLP-2/R cells to melphalan was 6.03.Besides melphalan it was cross resistant to other chemotherapeutic agents, including ADM, CTX, DDP and VP-16.The multiplication time was postponed(P < 0.05).Studies showed that FANCD2 protein monoubiquitination was enhanced, but the levels of P-gp and MRP expressions in the MOLP-2/R cells were similar with the parent cells.Conclusion:MOLP-2/R cell line may serve as an ideal model for exploring the mechanism of MDR.Over-expression of FANCD2 protein monoubiquitination might contribute to acquired drug resistance in MOLP-2/R cell line.展开更多
The RMR system is still very much applied in rock mechanics engineering context. It is based on the evaluation of six weights to obtain a final rating. To obtain the final rating a considerable amount of information i...The RMR system is still very much applied in rock mechanics engineering context. It is based on the evaluation of six weights to obtain a final rating. To obtain the final rating a considerable amount of information is needed concerning the rock mass which can be difficult to obtain in some projects or project stages at least with accuracy. In 2007 an alternative classification scheme based on the RMR, the Hierarchical Rock Mass Rating(HRMR) was presented. The main feature of this system was the adaptation to the level of knowledge existent about the rock mass to obtain the classification of the rock mass since it followed a decision tree approach. However, the HRMR was only valid for hard rock granites with low fracturing degrees. In this work, the database was enlarged with approximately 40% more cases considering other types of granite rock masses including weathered granites and based on this increased database the system was updated. Granite formations existent in the north of Portugal including Porto city are predominantly granites. Some years ago a light rail infrastructure was built in the city of Porto and surrounding municipalities which involved considerable challenges due to the high heterogeneity levels of the granite formations and the difficulties involved in their geomechanical characterization. In this work it is intended to provide also a contribution to improve the characterization of these formations with special emphasis to the weathered horizons. A specific subsystem applicable to the weathered formations was developed. The results of the validation of these systems are presented and show acceptable performances in identifying the correct class using less information than with the RMR system.展开更多
Presented is a new testing system based on using the factor models and self-organizing feature maps as well as the method of filtering undesirable environment influence. Testing process is described by the factor mode...Presented is a new testing system based on using the factor models and self-organizing feature maps as well as the method of filtering undesirable environment influence. Testing process is described by the factor model with simplex structure, which represents the influences of genetics and environmental factors on the observed parameters - the answers to the questions of the test subjects in one case and for the time, which is spent on responding to each test question to another. The Monte Carlo method is applied to get sufficient samples for training self-organizing feature maps, which are used to estimate model goodness-of-fit measures and, consequently, ability level. A prototype of the system is implemented using the Raven's Progressive Matrices (Advanced Progressive Matrices) - an intelligence test of abstract reasoning. Elimination of environment influence results is performed by comparing the observed and predicted answers to the test tasks using the Kalman filter, which is adapted to solve the problem. The testing procedure is optimized by reducing the number of tasks using the distribution of measures to belong to different ability levels after performing each test task provided the required level of conclusion reliability is obtained.展开更多
This paper introduced the recent study and application of composite pulse jigging theory in China. The paper has shown many features of the composite pulse jigging cycle with the experiment data from the site jigs.
The continuum-based(CB)shell theory is combined with the extended finite element method(X-FEM)in this paper to model crack propagation in shells under static and dynamic situations.Both jump function and asymptotic cr...The continuum-based(CB)shell theory is combined with the extended finite element method(X-FEM)in this paper to model crack propagation in shells under static and dynamic situations.Both jump function and asymptotic crack tip solution are adopted for describing the discontinuity and singularity of the crack in shells.Level set method(LSM)is used to represent the crack surface and define the enriched shape functions.Stress intensity factors(SIFs)are calculated by the displacement interpolation technique to prove the capability of the method and the maximum strain is applied for the fracture criterion.Also,an efficient integration scheme for the CB shell element with cracks is proposed.展开更多
As a popular meshfree particle method,the smoothed particle hydrodynamics(SPH) has suffered from not being able to di-rectly implement the solid boundary conditions.This influences the SPH approximation accuracy and h...As a popular meshfree particle method,the smoothed particle hydrodynamics(SPH) has suffered from not being able to di-rectly implement the solid boundary conditions.This influences the SPH approximation accuracy and hinders its further de-velopment and application to engineering and scientific problems.In this paper,a coupled dynamic solid boundary treatment(SBT) algorithm has been proposed,after investigating the features of existing SPH SBT algorithms.The novelty of the cou-pled dynamic SBT algorithm includes a new repulsive force between approaching fluid and solid particles,and a new numeri-cal approximation scheme for estimating field functions of virtual solid particles.The new SBT algorithm has been examined with three numerical examples including a typical dam-break flow,a dam-break flow with a sharp-edged obstacle,and a water entry problem.It is demonstrated that SPH with this coupled dynamic boundary algorithm can lead to accurate results with smooth pressure field,and that the new SBT algorithm is also suitable for complex and even moving solid boundaries.展开更多
The research of the motion and deformation of the RBCs is important to reveal the mechanism of blood diseases. A numerical method has been developed with level set formulation for elastic membrane immersed in incompre...The research of the motion and deformation of the RBCs is important to reveal the mechanism of blood diseases. A numerical method has been developed with level set formulation for elastic membrane immersed in incompressible fluid. The numerical model satisfies mass and energy conservation without the leaking problems in classical Immersed Boundary Method(IBM), at the same time, computing grid we used can be much smaller than the general literatures. The motion and deformation of a red blood cell(including pathological & normal status) in microvascular flow are simulated. It is found that the Reynolds number and membrane's stiffness play an important role in the transmutation and oscillation of the elastic membrane. The normal biconcave shape of the RBC is propitious to create high deformation than other pathological shapes. With reduced viscosity of the interior fluid both the velocity of the blood and the deformability of the cell reduced. With increased viscosity of the plasma both the velocity of the blood and the deformability of the cell reduced. The tank treading of the RBC membrane is observed at low enough viscosity contrast in shear flow. The tank tread fixed inclination angle of the cell depends on the shear ratio and viscosity contrast, which can be compared with the experimental observation well.展开更多
基金International Collaborative Research Project of Sika Technology AG of Switzerland,the Traffic Scientific Research Project in Jiangsu Province (No. 2010Y01)
文摘In order to improve the early-age cracking resistance of concrete, different types of superplasticizers are used. Two types of polycarboxlic salt/acid superplasticizers and one retarding naphthalene superplasticizer are selected to investigate the influence of superplasticizers on the early-age cracking resistance of the concrete by using the slab test and the temperature-stress test. The results show that the polycarboxlic salt/acid superplasticizer cannot always improve the cracking resistance capacity of the concrete compared with the naphthalene superplasticizer, which is related to the chemical structure of the polycarboxlic salt/acid superplasticizer. High plastic tensile strength and dynamic elastic modulus at the early stage are beneficial to avoid cracking, and low hydration heat is also helpful. The evolutions of the drying shrilakage stress and the hydration heat temperature stress varying with time can be comprehensively evaluated by means of the slab test and the temperature stress test.
基金Projects(50934002,51104011)supported by the National Natural Science Foundation of ChinaProject(2012BAB08B02)supported by the National Key Technologies R&D Program during the 12th Five-year Plan of China
文摘To minimize negative effects of geostress distribution on mining safety near the fault areas, the UPM40 triaxial geostress testing system was introduced to conduct in-situ geostress measurements at three sites and nine points by the borehole stress-relief method. The results of strain?confining pressure curves show that rock masses at the three measuring sites exhibit comprehensive linear elasticity in spite of various fissures or cracks within rocks. Horizontal and vertical stress components distribute discrepantly near the fault areas, and the maximum lateral pressure coefficient is as high as 6.15. The maximum principle stress ranges from 8.01 to 14.93 MPa, and stress directions are in the range of N78.07°W?N17.55°W. Geostresses near fault areas are dominated by the horizontal tectonic stresses, while the lower values, compared to those under similar geological conditions are due to stress release by the fault. Additionally, the fault and shear stress nearby are partially responsible for asymmetric elongation and southwesterly migration of orebodies.
基金The National Basic Research Program of China(973 Program)(No.2007CB714200)
文摘Based on the concept of stiffness degradation, a damage index of the whole frame and the storey is proposed for the frame seismic performance evaluation. The index is compatible with the non-linear static analysis (e. g. the pushover analysis), and the structural damage is considered via plastic hinges. Simultaneously, a practical approach is developed to obtain the relationships between the proposed index and earthquake intensities based on the capacity spectrum method. The proposed index is then illustrated through two low-rise reinforced concrete frames, and it is also compared with some other indices. The results indicate that the proposed index is on the safe side and not sensitive to the lateral load pattern. The storey index is helpful to reflect the storey damage and to uncover the position of the weak storey. Finally, the relationship between performance levels and damage index values is also proposed through statistical analysis for the performance-based seismic evaluation.
基金Supported by the National Natural Science Foundation of China(91541202,51276163)
文摘A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts.The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal and oblique impacts.A square-root correction for neck bases was modified in accuracy as well as scope of applications.In addition,process of jet formation and evolution was studied to reveal internal dynamics in drop impacts.It's found that pressure gradient and vortex are coexisting and completive reasons for jet topology while the inclined angle has a significant effect on them.Mechanisms of jet formation and evolution are different in the front and back necks.With the help of PDF distribution and correction calculation,a compromise in the competition is observed.This work lays a solid foundation for further studies of dynamics in gas-liquid flows.
基金supported by the National Natural Science Foundation of China (No. 50874103)the National Basic Research Program of China (No. 2010CB226805)+1 种基金the Natural Science Foundation of Jiangsu Province (No. BK2008135)the Open Foundation of State Key Laboratory of Geomechanics and Deep Underground Engineering (No. SKLGDUEK0905)
文摘Ground stress is the fundamental cause of deformation and failure during underground structural engineering. Field stress measurements in the main coal bed in the Lueliang mining area were made by the bore hole, stress relief method. From these data the ground stress distribution of the mining area was obtained. The relationship between the horizontal principal stress and the deformation and failure of a roadway is discussed with an engineering example. The results indicate that horizontal stress dominates in the shallow crust in the Ltiliang mining area. Roadways at different angles to the maximum principal stress have different levels of stress concentration. This leads to a significant difference in stability of the corresponding roadways. These research results provide an important criterion for determining roadway position and direction, stope layout, and roadway support design.
基金the National Natural Science Foundation of China(51176170,51276163)the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(LR12E06001)supported by the Fundamental Research Funds for the Central Universities
文摘Computational fluid dynamics is an efficient numerical approach for spray atomization study, but it is challenging to accurately capture the gas-liquid interface. In this work, an accurate conservative level set method is intro- duced to accurately track the gas-liquid interfaces in liquid atomization. To validate the capability of this method, binary drop collision and drop impacting on liquid film are investigated. The results are in good agreement with experiment observations. In addition, primary atomization (swirling sheet atomization) is studied using this method. To the swirling sheet atomization, it is found that Rayleigh-Taylor instability in the azimuthal direction causes the primary breakup of liquid sheet and complex vortex structures are clustered around the rim of the liq- uid sheet. The effects of central gas velocity and liquid-gas density ratio on atomization are also investigated. This work lays a solid foundation for further studvin~ the mechanism of s^rav atomization.
文摘The state of deep mine rigid shaft fUrniture horizontal force calculation in China is introduced and the calculating model of horizontal force is determined. Based on the interaction between hoisting vessel and shaft furniture, the vertical mobel test device is built and a large number of model tests and analyses are carried out. At last, the relationship between horizontal force and hoisting end load, hoisting speed or bunton level interval is gained. The three parameters horizontal force calculating equation of beep mine rigid shaft furniture is given and it can guide the design and calculation of shaft engineering.
文摘Objective:To find out how to overcome resistance during multiple myeloma(MM) treatment through establishing a multidrug resistant human multiple myeloma cell line and investigating its biological features.Methods:The parent cell line MOLP-2 was exposed to different concentrations of melphalan and a melphalan-resistant cell line MOLP-2/R was identified by continuous stepwise selection.The cell morphology and growth curves were examined.Protein levels of P-gp, MRP and FANCD2 monoubiquitination were checked by Western blotting.The IC50 of melphalan and resistance index(RI) were detected by MTT assay.Results:A melphalan-resistant cell line MOLP-2/R was finally identified.The RI of MOLP-2/R cells to melphalan was 6.03.Besides melphalan it was cross resistant to other chemotherapeutic agents, including ADM, CTX, DDP and VP-16.The multiplication time was postponed(P < 0.05).Studies showed that FANCD2 protein monoubiquitination was enhanced, but the levels of P-gp and MRP expressions in the MOLP-2/R cells were similar with the parent cells.Conclusion:MOLP-2/R cell line may serve as an ideal model for exploring the mechanism of MDR.Over-expression of FANCD2 protein monoubiquitination might contribute to acquired drug resistance in MOLP-2/R cell line.
文摘The RMR system is still very much applied in rock mechanics engineering context. It is based on the evaluation of six weights to obtain a final rating. To obtain the final rating a considerable amount of information is needed concerning the rock mass which can be difficult to obtain in some projects or project stages at least with accuracy. In 2007 an alternative classification scheme based on the RMR, the Hierarchical Rock Mass Rating(HRMR) was presented. The main feature of this system was the adaptation to the level of knowledge existent about the rock mass to obtain the classification of the rock mass since it followed a decision tree approach. However, the HRMR was only valid for hard rock granites with low fracturing degrees. In this work, the database was enlarged with approximately 40% more cases considering other types of granite rock masses including weathered granites and based on this increased database the system was updated. Granite formations existent in the north of Portugal including Porto city are predominantly granites. Some years ago a light rail infrastructure was built in the city of Porto and surrounding municipalities which involved considerable challenges due to the high heterogeneity levels of the granite formations and the difficulties involved in their geomechanical characterization. In this work it is intended to provide also a contribution to improve the characterization of these formations with special emphasis to the weathered horizons. A specific subsystem applicable to the weathered formations was developed. The results of the validation of these systems are presented and show acceptable performances in identifying the correct class using less information than with the RMR system.
文摘Presented is a new testing system based on using the factor models and self-organizing feature maps as well as the method of filtering undesirable environment influence. Testing process is described by the factor model with simplex structure, which represents the influences of genetics and environmental factors on the observed parameters - the answers to the questions of the test subjects in one case and for the time, which is spent on responding to each test question to another. The Monte Carlo method is applied to get sufficient samples for training self-organizing feature maps, which are used to estimate model goodness-of-fit measures and, consequently, ability level. A prototype of the system is implemented using the Raven's Progressive Matrices (Advanced Progressive Matrices) - an intelligence test of abstract reasoning. Elimination of environment influence results is performed by comparing the observed and predicted answers to the test tasks using the Kalman filter, which is adapted to solve the problem. The testing procedure is optimized by reducing the number of tasks using the distribution of measures to belong to different ability levels after performing each test task provided the required level of conclusion reliability is obtained.
文摘This paper introduced the recent study and application of composite pulse jigging theory in China. The paper has shown many features of the composite pulse jigging cycle with the experiment data from the site jigs.
基金supported by the National Natural Science Foundation of China(Grant No.11372157)
文摘The continuum-based(CB)shell theory is combined with the extended finite element method(X-FEM)in this paper to model crack propagation in shells under static and dynamic situations.Both jump function and asymptotic crack tip solution are adopted for describing the discontinuity and singularity of the crack in shells.Level set method(LSM)is used to represent the crack surface and define the enriched shape functions.Stress intensity factors(SIFs)are calculated by the displacement interpolation technique to prove the capability of the method and the maximum strain is applied for the fracture criterion.Also,an efficient integration scheme for the CB shell element with cracks is proposed.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10942004, 11172306)the National Defense Innovation Funds of the Chinese Academy of Sciences (Grant No. Y175031XML)
文摘As a popular meshfree particle method,the smoothed particle hydrodynamics(SPH) has suffered from not being able to di-rectly implement the solid boundary conditions.This influences the SPH approximation accuracy and hinders its further de-velopment and application to engineering and scientific problems.In this paper,a coupled dynamic solid boundary treatment(SBT) algorithm has been proposed,after investigating the features of existing SPH SBT algorithms.The novelty of the cou-pled dynamic SBT algorithm includes a new repulsive force between approaching fluid and solid particles,and a new numeri-cal approximation scheme for estimating field functions of virtual solid particles.The new SBT algorithm has been examined with three numerical examples including a typical dam-break flow,a dam-break flow with a sharp-edged obstacle,and a water entry problem.It is demonstrated that SPH with this coupled dynamic boundary algorithm can lead to accurate results with smooth pressure field,and that the new SBT algorithm is also suitable for complex and even moving solid boundaries.
基金supported by the National Key Project of Scientific and Technical Supporting Programs of China(Grant No.2014BAI11B06)the National Natural Science Foundation of China(Grant No.11172156)
文摘The research of the motion and deformation of the RBCs is important to reveal the mechanism of blood diseases. A numerical method has been developed with level set formulation for elastic membrane immersed in incompressible fluid. The numerical model satisfies mass and energy conservation without the leaking problems in classical Immersed Boundary Method(IBM), at the same time, computing grid we used can be much smaller than the general literatures. The motion and deformation of a red blood cell(including pathological & normal status) in microvascular flow are simulated. It is found that the Reynolds number and membrane's stiffness play an important role in the transmutation and oscillation of the elastic membrane. The normal biconcave shape of the RBC is propitious to create high deformation than other pathological shapes. With reduced viscosity of the interior fluid both the velocity of the blood and the deformability of the cell reduced. With increased viscosity of the plasma both the velocity of the blood and the deformability of the cell reduced. The tank treading of the RBC membrane is observed at low enough viscosity contrast in shear flow. The tank tread fixed inclination angle of the cell depends on the shear ratio and viscosity contrast, which can be compared with the experimental observation well.