Based on the serial-parallel model of single-layer board and the lamination theory, the forces exerted on different layers of the high-pressure hose and the resulting deformations were analyzed when the hose was radia...Based on the serial-parallel model of single-layer board and the lamination theory, the forces exerted on different layers of the high-pressure hose and the resulting deformations were analyzed when the hose was radially stretched. An equation was proposed to calculate the anisotropic elastic constant of the composite layer with the wound steel wires. Furthermore, the finite element analysis （FEA） model of the high-pressure hose was established, followed by a simulation of the forces that act on different layers, and their deformations. The simulation results show that the stress imposed on the inner reinforced layer and external reinforced layer of the high-pressure hose are approximately 150 MPa and 115 MPa, respectively, in the presence of inner pressure. The stress of the rubber coating and polyethylene coating is lower. The lowest stress occurs on the inner surface of the high-pressure hose and the rubber coating between the two composite layers. The deformation of the rubber layer in the inner surface of the high-pressure hose decreases gradually along the radial direction from the inner surface to the external surface. The deformation of the reinforced composite layer is less than that of the external surface of the rubber coating. The equivalent stress of the reinforced composite layer is higher than that caused by the inner pressure, due to the presence of both inner pressure and axial tension.展开更多
With the high-quality development of urban buildings,higher requirements are come up with for lateral bearing capacity of laterally loaded piles.Consequently,a more accurate analysis to predict the lateral response of...With the high-quality development of urban buildings,higher requirements are come up with for lateral bearing capacity of laterally loaded piles.Consequently,a more accurate analysis to predict the lateral response of the pile within an allowable displacement is an important issue.However,the current p-y curve methods cannot fully take into account the pile-soil interaction,which will lead to a large calculation difference.In this paper,a new analytical p-y curve is established and a finite difference method for determining the lateral response of pile is proposed,which can consider the separation effect of pile-soil interface and the coefficient of circumferential friction resistance.In particular,an analytical expression is developed to determine the compressive soil pressure by dividing the compressive soil pressure into two parts:initial compressive soil pressure and increment of compressive soil pressure.In addition,the relationship between compressive soil pressure and horizontal displacement of the pile is established based on the reasonable assumption.The correctness of the proposed method is verified through four examples.Based on the verified method,a parametric analysis is also conducted to investigate the influences of factors on lateral response of the pile,including internal friction angle,pile length and elastic modulus of pile.展开更多
Rainfall, runoff(surface runoff and interflow) and soil loss were recorded from 2002 to2005 in an experiment with four treatments on sloping red soil land in southern China. Treatments consisted of bare sloping ground...Rainfall, runoff(surface runoff and interflow) and soil loss were recorded from 2002 to2005 in an experiment with four treatments on sloping red soil land in southern China. Treatments consisted of bare sloping ground(control check, CK),interplanting with soybean in spring or radish in autumn(I), level terrace(i.e., grass planted on the riser and bunds built at the edge of a bench terrace)(II), and level terraces of orchards with Bahia grass planted on the riser(III). The surface runoff and erosion in treatment II and III during the four years were low despite the occurrence of potentially erosive rains. By contrast, the CK plot had both the highest surface runoff coefficient and the highest sediment yield among all the plots. The surface runoff and soil erosion of the CK plot significantly differed from that of the treatment plots(p < 0.05). Additionally,Significant differences between the interflow of the CK plot and that of the treatment plots was found from April to August(p < 0.05). However, no significant differences between the CK and treatment plots were found from January to March and September to December. The order of the plots in terms of surface runoff coefficients and soil losses was: CK > I > III > II, whereas their order in terms of interflow was II > III > I > CK. The effects of treatment II were excellent, indicating that level terrace(i.e., grass planted on the riser and bunds built at the edge of a bench terrace) can be an excellent practice for soil and water conservation on sloping red soil land. Soil loss in southern China can be reduced through the widespread use of this approach.展开更多
The phenomenon of aggradation due to sediment accumulation upstream reservoirs had been studied in this research. For this purpose, groups of experiments were conducted in a laboratory with 25 m long, 0.80 m wide and ...The phenomenon of aggradation due to sediment accumulation upstream reservoirs had been studied in this research. For this purpose, groups of experiments were conducted in a laboratory with 25 m long, 0.80 m wide and 0.70 m deep channel. A block was built at the end of the channel to work as a dam to impound water. The channel was supplied with drainage pipes on both sides to release water out in a manner similar to what happens in reservoirs. The bed of the channel was filled with sand of 0.80 mm median sieve diameter and 0.72 geometric standard deviation. The slope was 0.0093 for all experiments. Two sizes of sand were used representing the sediment. The median diameter and geometric standard deviation of the first were 0.365 mm and 0.46 mm, respectively. The second sample had 0.65 mm median diameter and 0.67 standard deviation. A total of 70 experiments were conducted in two groups to examine effects of sediment transport rate, particle size of sediment and flow velocity on aggradation characteristics. The results showed that there was a strong linear direct relationship between aggradation elements （length and depth） with the rate of sediment transport. Groups of dimensionless parameters affecting the aggradation characteristics were used to develop empirical equations to predict the length, maximum depth of aggradation and predict transient bed profile. The results of empirical approach were compared with the measurement data and previous numerical method. The results indicated that the percentage error was 19% to 31% for length of aggradation and -21% to 26% for maximum depth of aggradation. The results also showed that the sediment materials were deposited closer to the body of the dam when the released water from the dam is higher than the inflow.展开更多
The impacts of future climate change on streamflow of the Dongliao River Watershed located in Jilin Prov-ince, China have been evaluated quantitatively by using a general circulation model （HadCM3） coupled with the ...The impacts of future climate change on streamflow of the Dongliao River Watershed located in Jilin Prov-ince, China have been evaluated quantitatively by using a general circulation model （HadCM3） coupled with the Soil and Water Assessment Tool （SWAT） hydrological model. The model was calibrated and validated against the historical monitored data from 2005 to 2009. The streamflow was estimated by downscaling HadCM3 outputs to the daily mean temperature and precipitation series, derived for three 30-year time slices, 2020s, 2050s and 2080s. Results suggest that daily mean temperature increases with a changing rate of 0.435~C per decade, and precipitation decreases with a changing rate of 0.761 mm per decade. Compared with other seasons, the precipitation in summer shows significant downward trend, while a significant upward trend in autumn. The annual streamflow demonstrates a general down-ward trend with a decreasing rate of 0.405 m^3/s per decade. The streamflow shows significant downward and upward trends in summer and in autumn, respectively. The decreasing rate of streamflow in summer reaches 1.97 m^3/s per decade, which contributes primarily to the decrease of streamflow. The results of this work would be of great benifit to the design of economic and social development planning in the study area.展开更多
Niemann-Pick type C2(NPC2) is a lysosome luminal protein that functions in concert with NPC1 to mediate egress of lowdensity lipoprotein-derived cholesterol from lysosome. The nuclear factor kappa B subunit 2(NF-κB2)...Niemann-Pick type C2(NPC2) is a lysosome luminal protein that functions in concert with NPC1 to mediate egress of lowdensity lipoprotein-derived cholesterol from lysosome. The nuclear factor kappa B subunit 2(NF-κB2) protein is a component of NF-κB transcription factor complex critically implicated in immune and inflammatory responses. Here, we report that NF-κB2 regulates intracellular cholesterol transport by controlling NPC2 expression. RNAi-mediated disruption of NF-κB2, as well as other signaling members of the non-canonical NF-κB pathway, caused intracellular cholesterol accumulation. Blockage of the non-canonical NF-κB pathway suppressed NPC2 expression, whereas Lymphotoxin β receptor(LTβR) activation or Baff receptor(BaffR) stimulation up-regulated the mRNA abundance and protein level of NPC2. Further, NF-κB2 activated NPC2 transcription through direct binding to its promoter region. We also observed cholesterol accumulation in NF-κB2-deficient zebrafish embryo and NF-κB2 mutant mice. Collectively, these data identify a regulatory role for the non-canonical NF-κB pathway in intracellular cholesterol trafficking and suggest a link between cholesterol transport and immune system.展开更多
The potential applications of superparamagnetic iron oxide nanoparticles （SPIONs） in several nanomedical fields have attract- ed intense interest based on the cell-nano interaction. However, the mechanisms underlyin...The potential applications of superparamagnetic iron oxide nanoparticles （SPIONs） in several nanomedical fields have attract- ed intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways： The SPIONs were distributed to daughter cells during mito- sis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage hut affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool.展开更多
文摘Based on the serial-parallel model of single-layer board and the lamination theory, the forces exerted on different layers of the high-pressure hose and the resulting deformations were analyzed when the hose was radially stretched. An equation was proposed to calculate the anisotropic elastic constant of the composite layer with the wound steel wires. Furthermore, the finite element analysis （FEA） model of the high-pressure hose was established, followed by a simulation of the forces that act on different layers, and their deformations. The simulation results show that the stress imposed on the inner reinforced layer and external reinforced layer of the high-pressure hose are approximately 150 MPa and 115 MPa, respectively, in the presence of inner pressure. The stress of the rubber coating and polyethylene coating is lower. The lowest stress occurs on the inner surface of the high-pressure hose and the rubber coating between the two composite layers. The deformation of the rubber layer in the inner surface of the high-pressure hose decreases gradually along the radial direction from the inner surface to the external surface. The deformation of the reinforced composite layer is less than that of the external surface of the rubber coating. The equivalent stress of the reinforced composite layer is higher than that caused by the inner pressure, due to the presence of both inner pressure and axial tension.
基金Project(52068004)supported by the National Natural Science Foundation of ChinaProject(2018JJA160134)supported by the Natural Science Foundation of Guangxi Province,ChinaProject(AB19245018)supported by Key Research Projects of Guangxi Province,China。
文摘With the high-quality development of urban buildings,higher requirements are come up with for lateral bearing capacity of laterally loaded piles.Consequently,a more accurate analysis to predict the lateral response of the pile within an allowable displacement is an important issue.However,the current p-y curve methods cannot fully take into account the pile-soil interaction,which will lead to a large calculation difference.In this paper,a new analytical p-y curve is established and a finite difference method for determining the lateral response of pile is proposed,which can consider the separation effect of pile-soil interface and the coefficient of circumferential friction resistance.In particular,an analytical expression is developed to determine the compressive soil pressure by dividing the compressive soil pressure into two parts:initial compressive soil pressure and increment of compressive soil pressure.In addition,the relationship between compressive soil pressure and horizontal displacement of the pile is established based on the reasonable assumption.The correctness of the proposed method is verified through four examples.Based on the verified method,a parametric analysis is also conducted to investigate the influences of factors on lateral response of the pile,including internal friction angle,pile length and elastic modulus of pile.
基金funded by the National Science and Technique Sustentation Project (Grant No. 2012BAJ25B01)
文摘Rainfall, runoff(surface runoff and interflow) and soil loss were recorded from 2002 to2005 in an experiment with four treatments on sloping red soil land in southern China. Treatments consisted of bare sloping ground(control check, CK),interplanting with soybean in spring or radish in autumn(I), level terrace(i.e., grass planted on the riser and bunds built at the edge of a bench terrace)(II), and level terraces of orchards with Bahia grass planted on the riser(III). The surface runoff and erosion in treatment II and III during the four years were low despite the occurrence of potentially erosive rains. By contrast, the CK plot had both the highest surface runoff coefficient and the highest sediment yield among all the plots. The surface runoff and soil erosion of the CK plot significantly differed from that of the treatment plots(p < 0.05). Additionally,Significant differences between the interflow of the CK plot and that of the treatment plots was found from April to August(p < 0.05). However, no significant differences between the CK and treatment plots were found from January to March and September to December. The order of the plots in terms of surface runoff coefficients and soil losses was: CK > I > III > II, whereas their order in terms of interflow was II > III > I > CK. The effects of treatment II were excellent, indicating that level terrace(i.e., grass planted on the riser and bunds built at the edge of a bench terrace) can be an excellent practice for soil and water conservation on sloping red soil land. Soil loss in southern China can be reduced through the widespread use of this approach.
文摘The phenomenon of aggradation due to sediment accumulation upstream reservoirs had been studied in this research. For this purpose, groups of experiments were conducted in a laboratory with 25 m long, 0.80 m wide and 0.70 m deep channel. A block was built at the end of the channel to work as a dam to impound water. The channel was supplied with drainage pipes on both sides to release water out in a manner similar to what happens in reservoirs. The bed of the channel was filled with sand of 0.80 mm median sieve diameter and 0.72 geometric standard deviation. The slope was 0.0093 for all experiments. Two sizes of sand were used representing the sediment. The median diameter and geometric standard deviation of the first were 0.365 mm and 0.46 mm, respectively. The second sample had 0.65 mm median diameter and 0.67 standard deviation. A total of 70 experiments were conducted in two groups to examine effects of sediment transport rate, particle size of sediment and flow velocity on aggradation characteristics. The results showed that there was a strong linear direct relationship between aggradation elements （length and depth） with the rate of sediment transport. Groups of dimensionless parameters affecting the aggradation characteristics were used to develop empirical equations to predict the length, maximum depth of aggradation and predict transient bed profile. The results of empirical approach were compared with the measurement data and previous numerical method. The results indicated that the percentage error was 19% to 31% for length of aggradation and -21% to 26% for maximum depth of aggradation. The results also showed that the sediment materials were deposited closer to the body of the dam when the released water from the dam is higher than the inflow.
基金Under the auspices of Major Science and Technology Program for Water Pollution Control and Treatment(No.2009ZX07526-006-04-01)
文摘The impacts of future climate change on streamflow of the Dongliao River Watershed located in Jilin Prov-ince, China have been evaluated quantitatively by using a general circulation model （HadCM3） coupled with the Soil and Water Assessment Tool （SWAT） hydrological model. The model was calibrated and validated against the historical monitored data from 2005 to 2009. The streamflow was estimated by downscaling HadCM3 outputs to the daily mean temperature and precipitation series, derived for three 30-year time slices, 2020s, 2050s and 2080s. Results suggest that daily mean temperature increases with a changing rate of 0.435~C per decade, and precipitation decreases with a changing rate of 0.761 mm per decade. Compared with other seasons, the precipitation in summer shows significant downward trend, while a significant upward trend in autumn. The annual streamflow demonstrates a general down-ward trend with a decreasing rate of 0.405 m^3/s per decade. The streamflow shows significant downward and upward trends in summer and in autumn, respectively. The decreasing rate of streamflow in summer reaches 1.97 m^3/s per decade, which contributes primarily to the decrease of streamflow. The results of this work would be of great benifit to the design of economic and social development planning in the study area.
基金supported by National Natural Science Foundation of China (91754102, 31771568, 31701030, 31601147, 31600651)111 Project of Ministry of Education of China (B16036)Natural Science Foundation of Hubei Province (2016CFA012)
文摘Niemann-Pick type C2(NPC2) is a lysosome luminal protein that functions in concert with NPC1 to mediate egress of lowdensity lipoprotein-derived cholesterol from lysosome. The nuclear factor kappa B subunit 2(NF-κB2) protein is a component of NF-κB transcription factor complex critically implicated in immune and inflammatory responses. Here, we report that NF-κB2 regulates intracellular cholesterol transport by controlling NPC2 expression. RNAi-mediated disruption of NF-κB2, as well as other signaling members of the non-canonical NF-κB pathway, caused intracellular cholesterol accumulation. Blockage of the non-canonical NF-κB pathway suppressed NPC2 expression, whereas Lymphotoxin β receptor(LTβR) activation or Baff receptor(BaffR) stimulation up-regulated the mRNA abundance and protein level of NPC2. Further, NF-κB2 activated NPC2 transcription through direct binding to its promoter region. We also observed cholesterol accumulation in NF-κB2-deficient zebrafish embryo and NF-κB2 mutant mice. Collectively, these data identify a regulatory role for the non-canonical NF-κB pathway in intracellular cholesterol trafficking and suggest a link between cholesterol transport and immune system.
基金supported by the National Basic Research Program of China,Ministry of Science and Technology of China (Grant Nos. 2006CB933202 and 2011CB933504) the National High Technology Research and Development Program of China (Grant No. 2008AA02Z425)a grant from the National Natural Science Foundation of China (Grant No.81071072)
文摘The potential applications of superparamagnetic iron oxide nanoparticles （SPIONs） in several nanomedical fields have attract- ed intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways： The SPIONs were distributed to daughter cells during mito- sis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage hut affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool.
