3M亲水性敷料(人工皮)用于压疮患者的效果观察

目的观察3M亲水性敷料(又称人工皮)对压疮创面的保护作用。方法将52例压疮患者随机分为观察组26例与对照组26例,观察组应用3M亲水性敷料保护创面,对照组用传统的无菌纱布保护创面,观察两组患者创面的愈合、疼痛感、创面损伤、换药次数。结果观察组和对照组比较,压疮创面肉芽生长速度提升,创面的愈合快、疼痛感减轻、损伤创面小、减少护士工作量。结论3M亲水性敷料用于保护压疮创面,能够促进压疮创面提前愈合,减轻患者痛苦,减少护理工作量。

3M人工皮亲水性敷料在压疮护理中的应用效果

目的探讨3M人工皮亲水性敷料在压疮护理中的应用效果。方法选取漯河医专一附院收治的74例压疮患者,按随机数表法分为对照组和观察组,各37例。对照组接受传统无菌纱布处理创面;观察组接受3M人工皮亲水性敷料处理创面。统计对比两组创面愈合、换药次数、换药疼痛感、创面再受损等情况。结果观察组创面愈合优良率为89.19%(33/37),高于对照组67.57%(25/37),差异有统计学意义(P<0.05);观察组换药次数少于对照组,且换药疼痛感、创面再受损发生率均低于对照组,差异有统计学意义(P<0.05)。结论 3M人工皮亲水性敷料应用于压疮患者,可减少换药次数,降低换药时损伤及疼痛感,加快创面愈合。

应用人工皮亲水性敷料预防人工耳蜗植入术后额部压疮效果观察

[目的]评价人工皮亲水性敷料对人工耳蜗植入术后压疮的预防效果。[方法]采用便利抽样法,选取某三级甲等医院耳鼻喉科行人工耳蜗植入术的双侧极重度感音神经性聋患儿300例,按入院时间分为两组。术前常规备皮,对照组术毕常规医用绷带加压包扎;观察组术毕应用人工皮亲水性敷料覆盖额部皮肤后,医用绷带加压包扎,比较两组患儿术后额部压疮的发生情况。[结果]观察组术后额部压疮发生率(1.75%)低于对照组(30.23%),两组比较差异有统计学意义(χ2=49.38,P<0.01);人工耳蜗植入术后压疮多发生于1岁~3岁患儿。[结论]1岁~3岁患儿人工耳蜗植入术后额部压疮高发,护理人员应给予更多的关注,准确评估压疮风险,及时采取预防措施。

某车型车内气味溯源研究

在常规的气味主观评价之外,采用气相色谱-质谱法(GC-MS)对某款车型气味进行溯源分析,并将主观气味评价和全谱分析方法结合,通过将主观感知与客观数据对比分析,按照全谱测试中的物质特性进行分析,初步筛选气味的风险物质。依据零部件与整车气味匹配度,识别出有气味问题的零部件。分析结果表明影响该款车型整车气味关键零件是座椅和门板,而影响两种零部件的主要材料是包覆皮革。通过对同一厂家溶剂型皮和水性皮,以及不同厂家水性皮气味的对比分析,选择了合适的水性皮。配合其他零件的部分改善,最终将整车气味等级提高至标准要求。

Human plasma protein binding of water soluble flavonoids extracted from citrus peels

The human plasma protein binding of water soluble flavonoids in the peels of five spices of citrus fruits was studied by ultrafiltration combined with HPLC.The flavonoids were extracted separately by hot and cold water,and higher total flavonoid contents were detected in the former extracts than the latter ones.All the extracts show significant scavenging abilities to both ABTS and DPPH free radicals,which indicates the health benefits of the water extracts of citrus fruits peels.For DPPH radical,the IC50values of hot extract follow as Navel orange(NO)≈Mandarin orange(MO)< Lemon(LE)< Lo tangerine(LO)< Pomelo(PO),while the rank is NO< PO<LE≈MO<LO for ABTS radical.The HPLC results reveal that the kinds and contents of the flavonoids detected in the extracts are different among the species.MO extract has the most neohesperidin dihydrochalcone of 118.76 μmol/L and quercetrin of 211.81 μmol/L of which are much more than the rest extracts.Pomelo extract has the most plentiful flavonoids of naringin with a concentration of 303.28 μmol/L.The high contents of myricetrin and dihydromyricetin which both are potent free radical scavengers may explain the highest free radical scavenging activity of the NO extract.The plasma binding rates decrease with the increasing concentrations of flavonoids,and the flavonoids having plenty hydroxyl groups on both A ring and B ring of the molecular skeleton have relative higher plasma binding rates.In addition,the plasma binding rates of flavonoids with saturated C3-C4 bond decrease significantly with the increasing concentrations.

ELEVATED SOLUBLE EPIDERMAL GROWTH FACTOR RECEPTOR LEVEL IN PITUITARY ADENOMA AND CARCINOMA

To investigate effect of the soluble epidermal growth factor receptor (sEGFR/sErbB1) level in the periph-eral blood in development, invasiveness, apoplexy of each type of pituitary tumor. Methods The sEGFR level was determined in peripheral serum from 190 patients with pituitary diseases by enzyme linked immunosobent assay. The sEGFR levels were measured in 10 pituitary Rathke’s pouch, 18 pituitary hyperplasia, 161 pituitary adenomas including 30 microadenomas, 83 large adenomas, 48 giant adenomas, 1 pituitary carcinoma, and 28 hea-lthy controls. Results In the patients with pituitary hyperplasia, microadenoma, large adenoma, giant adenoma, and pituitary carci-noma, the sEGFR level was 188.92 ± 32.62, 209.83 ± 19.01, 333.20 ± 69.33, 405.85 ± 37.38, and 617.45 fmol/mL indepen-dently. They were all significantly higher than patients with pituitary Rathke’s pouch (156.78 ± 18.24 fmol/mL, P < 0.001) and healthy control group (159.11 ± 40.50 fmol/mL, P < 0.05). The sEGFR level in pituitary carcinoma was higher than pi-tuitary adenoma. In patients with pituitary adenoma, the sEGFR level was positive correlated to the size of pituitary adeno-mas (r = 0.998), the significant difference was observed for the sEGFR level in each group of the patients with pituitary adenomas (P < 0.001). Furthermore, in patients with pituitary ACTH-secreting microadenomas, the serum sEGFR levels in invasiveness (295.00 ± 77.80 fmol/mL) was higher than that in non-invasiveness (210.60 ± 16.4 fmol/mL, P < 0.05). In pati-ents with pituitary ACTH-secreting, PRL-secreting, GH-secreting, and non-functioning large adenomas, the serum sEGFR levels in invasiveness (407.86 ± 28.50, 399.25 ± 30.10, 386.00 ± 13.08, and 369.25 ± 36.70 fmol/mL) was higher than that in non-invasiveness (335.25 ± 63.49, 300.64 ± 47.57, 297.00 ± 61.93, and 269.30 ± 25.68 fmol/mL) respectively (P < 0.05). In patients with invasive pituitary PRL-secreting, GH-secreting, and non-functioning giant adenomas, the serum sEGFR levels not significantly different in between invasiveness (417.50 ± 35.94, 409.50 ± 69.14, and 417.50 ± 44.13 fmol/mL) and non-invasiveness (386.00 ± 49.64, 417.50 ± 44.03, and 409.51 ± 35.17 fmol/mL) (P > 0.05). In patients with pituitary large adeno-mas, the sEGFR levels in pituitary apoplexy (377.48 ± 39.18 fmol/mL) was higher than that in non-pituitary apoplexy (343.18 ± 68.17 fmol/mL, P > 0.05). Conclusions The increased level of peripheral serum sEGFR is concomitant with development, proliferous size of the adenomas in patients with pituitary adenomas. In addition, the elevated levels of serum sEGFR occur in pituitary apoplexy as clinical active tumors, and the non-invasive ACTH secreting adenomas. The sEGFR levels could be differen-tiated helpfully between pituitary adenomas and non-pituitary adenomas. These data suggest that serum sEGFR could be as a referable marker of the size and activation of proliferation in pituitary adenoma.

Anti-inflammatory Activity and Antioxidant Potential of Aqueous Extracts from Stem Bark of Geoffroea decorticans

In the present work we investigated, for the first time, the anti-inflammatory activity and the antioxidant properties of aqueous and ethanolic extracts, obtained from stem bark of Geoffroea decorticans （Gill. ex Hook. et Am.） Burk. （Fabaceae）. G. decorticans, commonly known as ＂chafiar＂ or ＂chafiarcillo＂, is a traditional argentinean plant used as emollient, balsamic, antitussive, expectorant and anti-inflammatory. The stem bark was collected from San Francisco del Monte de Oro, San Luis, Argentina. Anti-inflammatory activity was evaluated by carrageenan-induced paw edema in rats. Antioxidant activity was tested using 1,1-Diphenyl-2-picrylhydrazyl radical-scavenging activity （DPPH）, 2,2＂-Azino-bis（3-ethylbenzthiazoline-6-sulphonic acid） radical scavenging activity （ABTS） and ferric ion-reducing power （RP-Fe） assays. Aqueous extract 10% p/v showed anti-inflammatory activity （3h, 48% inhibition, 5h 37% inhibition and 7h 17% inhibition） and antioxidant activity （DPPH, ICs0 （mg/mL） = 0.098 =1： 0.032; ABTS, ICs0 （mg/mL） = 0.022 ~ 0.343, RP-Fe IC50 （mg/mL） = 1.124 ~ 0.146）. In the other hand, the ethanolic extract 5% p/v, presented anti-inflammatory activity （3h, 34% inhibition, 5h 38% inhibition and 7h 35% inhibition） and antioxidant activity （DPPH, IC50 （mg/mL） = 0.133 q- 0.027; ABTS, IC50 （mg/mL） = 0.086 ＋ 0.262, RP-Fe IC50 （mg/mL） = 7.089 ± 0.104）. These results suggest that, also fruits, the aqueous and ethanolic extracts from the stem bark of G. decorticans present significant anti-inflammatory activity and antioxidant properties.

Study on the preparation and properties of sunscreen O/W/Si multiple emulsion

To solve the greasiness and irritation risks brought about by organic sun-screening agents in sunscreen emulsions,in this work,a sunscreen O/W/Si multiple emulsion was prepared by two-step emulsification method,in which the outer oil phase was silicone oil and the inner oil phase was solid lipid nanoparticles coated with organic sun-screening agent.Several influencing factors on the formation and stability of the emulsion were analyzed,including inorganic salts,the volume fraction of outer oil phase(silicone oil),and the dosage of W/O emulsifier.The in vitro sunscreen performance,water resistance and skin permeability of different types of sunscreen emulsions were further studied.The results showed that the sunscreen O/W/Si multiple emulsion containing 22.5%silicone oil,2.5%emulsifier and 0.2%NaCl had the best stability under the experimental conditions.The SPF value and water resistance of sunscreen O/W/Si multiple emulsion were slightly higher than those of sunscreen W/O emulsion,but significantly higher than those of sunscreen O/W emulsion.Compared with sunscreen W/O emulsion,the in vitro transdermal permeability of organic sun-screening agent in sunscreen O/W/Si multiple emulsion was reduced by approximately 60%,indicative of higher safety and good application prospect in sunscreen cosmetics.

Therapeutic Observation on Combined Acupuncture and Medication for Recurrent Facial Dermatitis

Objective: To observe the clinical efficacy of acupoint injection plus medication in treating recurrent facial dermatitis(RFD). Methods: Fifty-eight patients with RFD were randomized into a treatment group and a control group, 29 in each. The treatment group was intervened by acupoint injection with BCG-PSN plus oral administration of Fexofenadine Hydrochloride, and the control group was by Fexofenadine Hydrochloride only. The clinical efficacies were compared between the two groups, and a follow-up study was conducted to investigate the recurrence rate. Results: The total effective rate was 96.6% in the treatment group versus 65.5% in the control group, and the difference was statistically significant(P<0.01). Of the cured and improved patients in the treatment group, the recurrence rates were 10.7%, 25.0%, and 32.1% respectively 3 months, 6 months, and 12 months after treatment, versus 31.6%, 36.8%, and 73.7% in the control group, and the differences were statistically significant(P<0.05). Conclusion: Acupoint injection plus medication is an effective method in treating RFD.

Neuroprotective effects of nimodipine and MK-801 on acute infectious brain edema induced by injection of pertussis bacilli to neocortex of rats

Objective: To explore the mechanism and type of acute infectious brain edema induced by injection of pertussis bacilli (PB) in rat neocortex, to study the neuroprotective effect of non-competitive antagonist of N-methl-D-aspartate ( NMDA ) receptor ( MK-801 ) and antagonist of Ca 2+ channels ( nimodipine )on brain edema, and to investigate the relationship between percentage of water content and cytosolic free calcium concentration ( i) in synaptosomes or content of Evans Blue (EB). Methods: 95 SD rats were randomly divided into five groups, ie, normal control group, sham-operated control group, PB group, nimodipine treatment group and MK-801 pretreatment group. The acute infectious brain edema was induced by injection of PB into the rats. Quantitative measurements of water content and the concentration of EB were performed. i was determined in calcium fluorescent indication Fura-2/AM loaded neuronal synaptosome with a spectrofluorophotometer. To observe the effect of MK-801 and nimodipine, we administered MK-801 48 hours and 24 hours before the injection of PB in MK-801 pretreatment group, and nimodipine after the injection of PB in nimodipine treatment group. The specific binding of NMDA receptor was measured with -MK-801 in the neuronal membrane of cerebral cortex. Results: The levels of water content and EB content of brain tissues, and i in the neuronal synaptosomes increased more significantly in the PB-injected cerebral hemisphere in the PB group than those of normal control group and sham-operated control group (P< 0.05). The water content and i increased with the duration of infectious brain edema. Nimodipine administered after the injection of PB could significantly decrease the water content, EB and i (P< 0.05). MK-801 could significantly decrease the water content, EB and i in 4 h and 24 h groups (P< 0.05). The Kd values were 30.5 nmol/L ±3.0 nmol/L and 42.1 nmol/L ±4.2 nmol/L in PB group and NS group respectively (P< 0.05), and Bmax were 0.606 pmol/mg.pro ±0.087 pmol/mg.pro and 0.623 pmol/mg.pro ±0.082 pmol/mg.pro respectively, without statistical significance (P> 0.05). Conclusions: The changes in the permeability of blood-brain barrier (BBB) and Ca 2+-overload may participate in the pathogenesis of infectious brain edema. Treatment with nimodipine can dramatically reduce the damage of brain edema and demonstrate neuroprotective effect on brain edema by inhibiting the excess of Ca 2+ influx and reducing the permeability of BBB. MK-801 pretreatment may inhibit the delayed Ca 2+ influx into the neurons. The infectious brain edema is not only cytotoxic brain edema (intracellular edema) but also vasogenic brain edema (extracellular edema) followed by earlier BBB breakdown, so infectious brain edema is complicated with brain edema.

Energy-dissipative dual-crosslinked hydrogels for dynamically super-tough sensors

In the fields of electronic skin and soft wearable sensors,intrinsically stretchable conductors undergo rapid development;however,practical applications of artificial skinlike materials/devices have not been realized because of the difficulty in combining the electromechanical properties and sensing performance.Contrarily,insoluble inorganic conductive domains in the hydrogel matrix are generally incompatible with surrounding elastic networks,decreasing the mechanical strength.Usually,the hydrogels are vulnerable either to severe mechanical stimuli or large deformation,especially when notches are induced.In this study,based on an energy-dissipative dual-crosslinked conductive hydrogel,a mechanically durable and super-tough strain sensor was developed.The highly soft yet dynamically tough hydrogel demonstrated high ionic conductivity(30.2 mS cm^(-1)),ultrastretchability(>600%strain),and superior linear dependence of strain sensitivity with a maximum gauge factor of 1.2 at 500%strain.Because of these advantageous synergistic effects,the resultant hydrogel strain sensor demonstrated reliable and stable detection of a large range of human motion and subtle vibrations.Moreover,it impressively exhibited super toughness that could endure consecutive treading pressure and even retain normal operation after 20 times of car run-over on the road.These demonstrations highly confirm the sensor’s superior mechanical durability and reliability,displaying great potential in developing next-generation mechanically adaptable sensors.

Effect of total phosphorous pollution on cavitation pressure characteristics of working water used in turbines

Many experiments have proven that with increasing silt and gas(out-of-phase media)content in water,the cavitation characteristics change and the cavitation pressure increases.Currently,many large reservoirs in China are polluted by total phosphorus(TP)and other chemical contaminants because of the use of phosphate fertilizer runoff from agriculture.However,research regarding how chemical pollutants(in the form of out-of-phase media)affect the cavitation pressure characteristics of water is sparse.In this paper,the Goupitan Hydropower Station,the largest hydropower reservoir on the Wujiang River,which is heavily polluted by TP,is taken as an example to evaluate the effects of chemical pollution on water cavitation pressure characteristics.In this study,the cavitation pressure characteristics of polluted and clean water are compared.The results show that the cavitation pressure of water polluted by chemicals is larger than that of clean water.In a hydraulic power generation system,cavitation and cavitation erosion are likely to occur earlier in runners when the fluid is polluted.These results are of great importance to further studies of cavitation theory and can directly influence the arrangement of turbines in practical engineering.