Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apoli...Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apolipoprotein E （APOE） genotype as well as sex could influence the functional outcomes of the treatments. Methods： For a period of 16 weeks, separate groups of male and female mice expressing either the human APOE3 or APOE4 isoforms were fed either a control diet （NIH-31） or the control diet supplemented with vitamins E and C （1.12 IU/g diet a-tocopheryl acetate and 1.65 mg/g ascorbic acid）. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure cognitive and affective function. Results： There was no effect of genotype or treatment on the learning performance in the Morris water maze. In the discriminated avoidance task, APOE4 mice performed better in learning the discrimination component of the task. Overall, exercise improved performance of APOE4 and APOE3 mice on various aspects of the active avoidance task. Antioxidant supplementation improved performance only in the APOE4 mice. On the test for anxiety, APOE4 mice spent more time in the open arms and supplementation with antioxidant reversed that effect. Conclusion： Exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOE4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.展开更多
Sense-oriented reasoning （SOR） was analyzed by comparing the reasoning of tribal and modem societies on a specific subject, the conception and birth of a child. Tribal societies have beliefs, which are difficult to ...Sense-oriented reasoning （SOR） was analyzed by comparing the reasoning of tribal and modem societies on a specific subject, the conception and birth of a child. Tribal societies have beliefs, which are difficult to understand by modem societies. Their reasoning becomes understandable only when considering that their observations are limited to the macrocosm. Modem societies have access to the microcosm with a microscope, where different biological mechanisms for the conception of a child were discovered. Since the tribes＇ macroscopical observations were different, their conclusions became necessarily different. The inheritance problem can only be solved by genes at the microscopic level, to which tribal societies had no access. With observations limited to the macrocosm, tribes logically invoked invisible child-spirits of ancestors wanting to be reincarnated in children of the same tribe. Besides the different access to observation, the reasoning of both societies is similar and built around the investigation of a final sense. Reasoning progresses after a phase without any quest for sense through three progressive levels： （1） primary sense, （2） corrected sense, and （3） verified sense. In tribal societies, reasoning is interrupted at the primary sense level when it seems consistent with their general beliefs and traditions. This resembles coherentist theories of epistemic justification, in which justification is only a function of coherence between beliefs. Tribal societies realize the input problem of these theories, since they have no access to the microcosm and also illustrate the Gettier problem. Modem societies progress to the higher levels of corrected and verified sense reasoning, even if inconsistent with their prior beliefs. They initially imagined genes as a hypothetic missing link for inheritance, which relies on a start observation concerning the character of ancestors to the target observation, the similarity with the character of children. If the missing link is definitely verified, it shows a chain of justified beliefs between both observations, allowing the initially hypothetic missing link to be retrospectively considered as the real cause. The SOR of modem societies resembles the extemalist version of foundationalism of epistemic justification, in which the necessary non-inferential justification is represented by the target observation.展开更多
The cognition of low-carbon tourism among tourists is closely related to education level.In this study,the degree of coordination of low-carbon cognition with different educational levels is assessed by the coupling m...The cognition of low-carbon tourism among tourists is closely related to education level.In this study,the degree of coordination of low-carbon cognition with different educational levels is assessed by the coupling model in Wutai Mountain,and the effect of each factor on low-carbon cognition is analyzed by the geographical detector.The results show that:(1)The six cognition aspects of low-carbon tourism gradually transition from the level of intermediate coordination to good coordination with the advancement of the education level.Both the low-level and lower-level tourists belong to the lag type of low-carbon visiting cognition,and the higher-level tourists belong to the lag type of low-carbon shopping cognition,while the high-level tourists show the lag type of low-carbon food cognition.(2)According to the individual factors and interactive effects in the geographical detector,each impacting factor has a decisive effect on tourists’cognition of low-carbon tourism,and the effect of any two factors after interaction shows either a double-factor or nonlinear enhancement.The findings of this study provide valuable practical implications for helping tourism destinations to educate tourists and improve their low-carbon tourism options.At the same time,this study will provide theoretical standards for measuring tourists’cognition of low-carbon tourism,so as to enrich and improve the theoretical research related to low-carbon tourism.展开更多
Objective： To study the relative specificity of Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） in improving the cognitive function of patients with vascular dementia （VD）. Method： Fifty VD cases were ran...Objective： To study the relative specificity of Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） in improving the cognitive function of patients with vascular dementia （VD）. Method： Fifty VD cases were randomized into 5 groups, which were treated with routine points, routine points plus Baihui （GV 20）, routine points plus Shuigou （GV 26）, routine points plus Shenmen （HT 7）, and routine points plus the above-mentioned three points together respectively. The scale of elderly cognitive function （SECF） was measured before and after the treatment for statistical management. Results： The total score of SECF was markedly increased after Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） were added to the routine points, more specifically, with addition of Baihui （GV 20）, the patients with VD got increased scores in such aspects as orientation, instant memory, long-term anamnesis, animal names, cancellation and calculation, and classification and analogy; with addition of Shuigou （GV 26）, the patients with VD got increased scores in such aspects as orientation, cancellation and calculation, and classification and analogy; with addition of Shenmen （HT 7）, the patients with VD got increased scores in such aspects as digital scope, animal names, and classification and analogy. Conclusion： Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） could improve the cognitive function of patients with VD, and the combination of the three points got the best result despite their respective specificity.展开更多
Objectives： The aim of the study is to evaluate the cognitive-enhancing effects of hydrolysate of polyga- lasaponin （HPS） on senescence accelerate mouse P8 （SAMP8） mice, an effective Alzheimer＇s disease （AD） m...Objectives： The aim of the study is to evaluate the cognitive-enhancing effects of hydrolysate of polyga- lasaponin （HPS） on senescence accelerate mouse P8 （SAMP8） mice, an effective Alzheimer＇s disease （AD） model, and to research the relevant mechanisms. Methods： The cognitive-enhancing effects of HPS on SAMP8 mice were assessed using Morris water maze （MWM） and step-through passive avoidance tests. Then N-methyl-D-aspartate （NMDA） receptor subunit expression for both the cortex and hippocampus of mice was observed using Western blot- ting. Results： HPS （25 and 50 mg/kg） improved the escape rate and decreased the escape latency and time spent in the target quadrant for the SAMP8 mice in the MWM after oral administration of HPS for 10 d. Moreover, it decreased error times in the passive avoidance tests. Western blotting showed that HPS was able to reverse the levels of NMDAR1 and NMDAR2B expression in the cortex or hippocampus of model mice. Conclusions： The present study suggested that HPS can improve cognitive deficits in SAMP8 mice, and this mechanism might be associated with NMDA receptor （NMDAR）-related pathways.展开更多
OBJECTIVE:To observe the effects of Compound Danshen Tablets(CDST) on spatial cognition and expression of brain b-amyloid precursor protein(β-APP) in a rat model of Alzheimer's disease.METHODS:The rat model of Al...OBJECTIVE:To observe the effects of Compound Danshen Tablets(CDST) on spatial cognition and expression of brain b-amyloid precursor protein(β-APP) in a rat model of Alzheimer's disease.METHODS:The rat model of Alzheimer's disease(AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage.Rat behavior was monitored using the Morris water maze,and the expression of β-APP in rat brain tissue was detected via immunohistochemistry.RESULTS:CDST significantly improved spatial cognition and decreased β-APP expression in the cortex and hippocampus(P<0.05,P<0.01).CONCLUSIONS:CDST can significantly improve spatial cognition in a rat model of AD.This observation is possibly related to a reduction in β-APP ex-pression in the rat brain.展开更多
基金supported by grant MRG-10-173988 and donation from the Pine Family Foundation
文摘Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apolipoprotein E （APOE） genotype as well as sex could influence the functional outcomes of the treatments. Methods： For a period of 16 weeks, separate groups of male and female mice expressing either the human APOE3 or APOE4 isoforms were fed either a control diet （NIH-31） or the control diet supplemented with vitamins E and C （1.12 IU/g diet a-tocopheryl acetate and 1.65 mg/g ascorbic acid）. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure cognitive and affective function. Results： There was no effect of genotype or treatment on the learning performance in the Morris water maze. In the discriminated avoidance task, APOE4 mice performed better in learning the discrimination component of the task. Overall, exercise improved performance of APOE4 and APOE3 mice on various aspects of the active avoidance task. Antioxidant supplementation improved performance only in the APOE4 mice. On the test for anxiety, APOE4 mice spent more time in the open arms and supplementation with antioxidant reversed that effect. Conclusion： Exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOE4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.
文摘Sense-oriented reasoning （SOR） was analyzed by comparing the reasoning of tribal and modem societies on a specific subject, the conception and birth of a child. Tribal societies have beliefs, which are difficult to understand by modem societies. Their reasoning becomes understandable only when considering that their observations are limited to the macrocosm. Modem societies have access to the microcosm with a microscope, where different biological mechanisms for the conception of a child were discovered. Since the tribes＇ macroscopical observations were different, their conclusions became necessarily different. The inheritance problem can only be solved by genes at the microscopic level, to which tribal societies had no access. With observations limited to the macrocosm, tribes logically invoked invisible child-spirits of ancestors wanting to be reincarnated in children of the same tribe. Besides the different access to observation, the reasoning of both societies is similar and built around the investigation of a final sense. Reasoning progresses after a phase without any quest for sense through three progressive levels： （1） primary sense, （2） corrected sense, and （3） verified sense. In tribal societies, reasoning is interrupted at the primary sense level when it seems consistent with their general beliefs and traditions. This resembles coherentist theories of epistemic justification, in which justification is only a function of coherence between beliefs. Tribal societies realize the input problem of these theories, since they have no access to the microcosm and also illustrate the Gettier problem. Modem societies progress to the higher levels of corrected and verified sense reasoning, even if inconsistent with their prior beliefs. They initially imagined genes as a hypothetic missing link for inheritance, which relies on a start observation concerning the character of ancestors to the target observation, the similarity with the character of children. If the missing link is definitely verified, it shows a chain of justified beliefs between both observations, allowing the initially hypothetic missing link to be retrospectively considered as the real cause. The SOR of modem societies resembles the extemalist version of foundationalism of epistemic justification, in which the necessary non-inferential justification is represented by the target observation.
基金Supported by Program for the Philosophy and Social Sciences Research of Higher Learning Institutions of Shanxi(2023W064)。
文摘The cognition of low-carbon tourism among tourists is closely related to education level.In this study,the degree of coordination of low-carbon cognition with different educational levels is assessed by the coupling model in Wutai Mountain,and the effect of each factor on low-carbon cognition is analyzed by the geographical detector.The results show that:(1)The six cognition aspects of low-carbon tourism gradually transition from the level of intermediate coordination to good coordination with the advancement of the education level.Both the low-level and lower-level tourists belong to the lag type of low-carbon visiting cognition,and the higher-level tourists belong to the lag type of low-carbon shopping cognition,while the high-level tourists show the lag type of low-carbon food cognition.(2)According to the individual factors and interactive effects in the geographical detector,each impacting factor has a decisive effect on tourists’cognition of low-carbon tourism,and the effect of any two factors after interaction shows either a double-factor or nonlinear enhancement.The findings of this study provide valuable practical implications for helping tourism destinations to educate tourists and improve their low-carbon tourism options.At the same time,this study will provide theoretical standards for measuring tourists’cognition of low-carbon tourism,so as to enrich and improve the theoretical research related to low-carbon tourism.
文摘Objective： To study the relative specificity of Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） in improving the cognitive function of patients with vascular dementia （VD）. Method： Fifty VD cases were randomized into 5 groups, which were treated with routine points, routine points plus Baihui （GV 20）, routine points plus Shuigou （GV 26）, routine points plus Shenmen （HT 7）, and routine points plus the above-mentioned three points together respectively. The scale of elderly cognitive function （SECF） was measured before and after the treatment for statistical management. Results： The total score of SECF was markedly increased after Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） were added to the routine points, more specifically, with addition of Baihui （GV 20）, the patients with VD got increased scores in such aspects as orientation, instant memory, long-term anamnesis, animal names, cancellation and calculation, and classification and analogy; with addition of Shuigou （GV 26）, the patients with VD got increased scores in such aspects as orientation, cancellation and calculation, and classification and analogy; with addition of Shenmen （HT 7）, the patients with VD got increased scores in such aspects as digital scope, animal names, and classification and analogy. Conclusion： Baihui （GV 20）, Shuigou （GV 26） and Shenmen （HT 7） could improve the cognitive function of patients with VD, and the combination of the three points got the best result despite their respective specificity.
基金Project supported by the Medicinal Science and Technology Research Project(No.BWS11J052)the Ministry of Science and Technology of China(No.2012ZX09J12201)the Department of Science and Technology of Xinjiang Uygur Autonomous Region,China(No.201491174)
文摘Objectives： The aim of the study is to evaluate the cognitive-enhancing effects of hydrolysate of polyga- lasaponin （HPS） on senescence accelerate mouse P8 （SAMP8） mice, an effective Alzheimer＇s disease （AD） model, and to research the relevant mechanisms. Methods： The cognitive-enhancing effects of HPS on SAMP8 mice were assessed using Morris water maze （MWM） and step-through passive avoidance tests. Then N-methyl-D-aspartate （NMDA） receptor subunit expression for both the cortex and hippocampus of mice was observed using Western blot- ting. Results： HPS （25 and 50 mg/kg） improved the escape rate and decreased the escape latency and time spent in the target quadrant for the SAMP8 mice in the MWM after oral administration of HPS for 10 d. Moreover, it decreased error times in the passive avoidance tests. Western blotting showed that HPS was able to reverse the levels of NMDAR1 and NMDAR2B expression in the cortex or hippocampus of model mice. Conclusions： The present study suggested that HPS can improve cognitive deficits in SAMP8 mice, and this mechanism might be associated with NMDA receptor （NMDAR）-related pathways.
基金Supported by the National Science and Technology "12th Five-years" Major Special-purpose Foundation (No 2011ZX09201-201-01)
文摘OBJECTIVE:To observe the effects of Compound Danshen Tablets(CDST) on spatial cognition and expression of brain b-amyloid precursor protein(β-APP) in a rat model of Alzheimer's disease.METHODS:The rat model of Alzheimer's disease(AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage.Rat behavior was monitored using the Morris water maze,and the expression of β-APP in rat brain tissue was detected via immunohistochemistry.RESULTS:CDST significantly improved spatial cognition and decreased β-APP expression in the cortex and hippocampus(P<0.05,P<0.01).CONCLUSIONS:CDST can significantly improve spatial cognition in a rat model of AD.This observation is possibly related to a reduction in β-APP ex-pression in the rat brain.
