In order to study the interaction between various fouling particles and ballast,a multi-layer and multi-scale discrete element model(DEM)including the sleeper,ballast bed and the surface layer of subgrade was develope...In order to study the interaction between various fouling particles and ballast,a multi-layer and multi-scale discrete element model(DEM)including the sleeper,ballast bed and the surface layer of subgrade was developed.Two typical fouling particles,the hard particles(sand)and soft ones(coal fines),are considered.A support stiffness test of the ballast bed under various fouling conditions was conducted to calibrate the microscopic parameters of the contact model.With the model,the influence of fouling particles on the mechanical behavior and deformation of the ballast bed was analyzed from macro and micro perspectives.The results show that the increase in the strength of the fouling particles enlarges the stiffness of the ballast bed.Hard particles increase the uniformity coefficient of the contact force bondγof ballast by 50.4%.Fouling particles increase the average stress in the subgrade,soft particles by 2 kPa and hard particles by 1 kPa.Hard particles can reduce the elasticity,plastic deformation and energy dissipation in the track structure.As the fouling particle changes from hard to soft,the proportion of the settlement in ballast bed increases to 40.5%and surface layer of swbgrade settlement decreases to 59.5%.Thus,the influence of fouling particles should be considered carefully in railway design and maintenance.展开更多
Arsenic-contaminated drinking water is a public health problem in countries such as Taiwan, Bangladesh, United States, Mexico, Argentina, and Chile. The chronic ingestion of arsenic-contaminated drinking water increas...Arsenic-contaminated drinking water is a public health problem in countries such as Taiwan, Bangladesh, United States, Mexico, Argentina, and Chile. The chronic ingestion of arsenic-contaminated drinking water increases the risk for ischemic heart disease, cerebrovascular disease, and prevalence of hypertension. Although toxic arsenic effects are controversial, there is evidence that a high concentration of arsenic may induce hypertension through increase in vascular tone and resistance. Vascular tone is regulated by the rhythmic contractions of the blood vessels, generated by calcium oscillations in the cytosol of vascular smooth muscle cells. To regulate the cytosolic calcium oscillations, the membrane oscillator model involves the participation of Ca2+ channels, calcium-activated K+ channels, Na+/Ca2+exchange, plasma membrane Ca2+-ATPase, and the Na+/K+-ATPase. However, little is known about the role of K+ uptake by sodium transporters [Na+/K+-ATPase or Na+-K+-2Cl-(NKCC1)] on the rhythmic contractions.Vascular rhythmic contractions, or vasomotion are a local mechanism to regulate vascular resistance andblood flow. Since vascular rhythmic contractions of blood vessels are involved in modulating the vascular resistance, the blood flow, and the systemic pressure,we suggest a model explaining the participation of the sodium pump and NKCC1 co-transporter in low dose arsenic exposure effects on vasomotion and vascular dysfunction.展开更多
[Objective]The aim was to introduce T-DNA into watermelon for its molecular marker research.[Method]Based on the method of foreign DNA introduced to Arabidopsis thaliana via dipping flowers,the stigma smear was used t...[Objective]The aim was to introduce T-DNA into watermelon for its molecular marker research.[Method]Based on the method of foreign DNA introduced to Arabidopsis thaliana via dipping flowers,the stigma smear was used to transfer T-DNA into watermelon and its molecular marker research was carried out.[Result]The ideal transformed species was ZXG01078 for the highest fruit setting rate and the most deviant seedlings.The best concentration of kanamycin for treating watermelon seeds was 500-700 mg/L with differences among the species.The best position was spire leaf or young leaf and the best concentration of kanamycin for treating the watermelon leaf was 4 000-8 000 mg/L with no significant difference among species.The steadily variation appearing of growing pointless and conjoined twin seedlings indicated that the normal growth had been interfered by foreign DNA in the progeny.[Conclusion]This study had provided basis for the further research on watermelon.展开更多
基金Project(51978045) supported by the National Natural Science Foundation of ChinaProject([2017]7) supported by Shenshuo Science and Technology Development Project,China。
文摘In order to study the interaction between various fouling particles and ballast,a multi-layer and multi-scale discrete element model(DEM)including the sleeper,ballast bed and the surface layer of subgrade was developed.Two typical fouling particles,the hard particles(sand)and soft ones(coal fines),are considered.A support stiffness test of the ballast bed under various fouling conditions was conducted to calibrate the microscopic parameters of the contact model.With the model,the influence of fouling particles on the mechanical behavior and deformation of the ballast bed was analyzed from macro and micro perspectives.The results show that the increase in the strength of the fouling particles enlarges the stiffness of the ballast bed.Hard particles increase the uniformity coefficient of the contact force bondγof ballast by 50.4%.Fouling particles increase the average stress in the subgrade,soft particles by 2 kPa and hard particles by 1 kPa.Hard particles can reduce the elasticity,plastic deformation and energy dissipation in the track structure.As the fouling particle changes from hard to soft,the proportion of the settlement in ballast bed increases to 40.5%and surface layer of swbgrade settlement decreases to 59.5%.Thus,the influence of fouling particles should be considered carefully in railway design and maintenance.
文摘Arsenic-contaminated drinking water is a public health problem in countries such as Taiwan, Bangladesh, United States, Mexico, Argentina, and Chile. The chronic ingestion of arsenic-contaminated drinking water increases the risk for ischemic heart disease, cerebrovascular disease, and prevalence of hypertension. Although toxic arsenic effects are controversial, there is evidence that a high concentration of arsenic may induce hypertension through increase in vascular tone and resistance. Vascular tone is regulated by the rhythmic contractions of the blood vessels, generated by calcium oscillations in the cytosol of vascular smooth muscle cells. To regulate the cytosolic calcium oscillations, the membrane oscillator model involves the participation of Ca2+ channels, calcium-activated K+ channels, Na+/Ca2+exchange, plasma membrane Ca2+-ATPase, and the Na+/K+-ATPase. However, little is known about the role of K+ uptake by sodium transporters [Na+/K+-ATPase or Na+-K+-2Cl-(NKCC1)] on the rhythmic contractions.Vascular rhythmic contractions, or vasomotion are a local mechanism to regulate vascular resistance andblood flow. Since vascular rhythmic contractions of blood vessels are involved in modulating the vascular resistance, the blood flow, and the systemic pressure,we suggest a model explaining the participation of the sodium pump and NKCC1 co-transporter in low dose arsenic exposure effects on vasomotion and vascular dysfunction.
基金Supported by Crop Germplasm Resources Protection Project of Ministry of Agriculture(NB08-2130135-44)National Science and Technology Infrastructure Project(2005DKA21001-23)
文摘[Objective]The aim was to introduce T-DNA into watermelon for its molecular marker research.[Method]Based on the method of foreign DNA introduced to Arabidopsis thaliana via dipping flowers,the stigma smear was used to transfer T-DNA into watermelon and its molecular marker research was carried out.[Result]The ideal transformed species was ZXG01078 for the highest fruit setting rate and the most deviant seedlings.The best concentration of kanamycin for treating watermelon seeds was 500-700 mg/L with differences among the species.The best position was spire leaf or young leaf and the best concentration of kanamycin for treating the watermelon leaf was 4 000-8 000 mg/L with no significant difference among species.The steadily variation appearing of growing pointless and conjoined twin seedlings indicated that the normal growth had been interfered by foreign DNA in the progeny.[Conclusion]This study had provided basis for the further research on watermelon.