AIM: To demonstrate the effect of Hewei-Decoction (Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori. METHODS: Ninety patients with CAG entering the inves...AIM: To demonstrate the effect of Hewei-Decoction (Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori. METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs. Hewei-Decoction was taken by all the patients orally for 4 or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori.X2 test was used to compare the efficacy between H pylori-positive and negative cases, and to disclose the relationship between efficacy and eradication of H pylori. RESULTS: In patients with six different syndrome types, the efficacy of Hewei-Decoction was 91.67% (11/12), 92.86% (13/14), 97.22% (35/36), 87.50% (14/16), 75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14), 77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and 25.00% (1/4), respectively. The total efficacy was 91.11% (82/90), and the rate of highly efficacious was 60.00% (54/90). The eradication rate of H pylori was 67.86% (38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in H pylori-negative cases with the total effect of 96.43% vs 82.35% (P<0.05). In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pylori-existent cases with the total effect of 97.37% vs 72.22% (P<0.01). CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.展开更多
Objectives:Helicobacter pylori(H.pylori)infection is one of the most common infections,for which wellestablished medical treatments have been widely used,such as quadruple therapy and sequential therapy.However,some p...Objectives:Helicobacter pylori(H.pylori)infection is one of the most common infections,for which wellestablished medical treatments have been widely used,such as quadruple therapy and sequential therapy.However,some patients still suffer from the infection after multiple treatment.Traditional Chinese medicine(TCM)has been widely used to treat the H.pylori infection.Whether the combination of TCM therapy and antibiotic treatment is effective for these patients with repeated infection with H.pylori needs clinical observation.Methods:In this study,we reported two cases with refractory H.pylori infection.One is a 60-yearold Chinese woman with diagnoses of chronic atrophic gastritis and H.pylori infection,who has an uncomfortable feeling in her stomach with a poor appetite,depression and irregular defecations.The other is a Vietnamese woman aged 46,who had abdominal pain for 11 years.We treated the two patients with Chai Ping Decoction,combined with sequential therapy.Results:Both patients had pain relieved and H.pylori infection eradicated after treatment.Conclusion:TCM therapy may eliminate H.pylori infection well with sequential therapy.Based on the TCM theory,the patients who were diagnosed as spleen deficiency and dampness with abdominal uncomfortable symptoms could be well treated.展开更多
目的观察吴门芪藤汤辅助治疗膝关节软骨损伤性关节炎的临床疗效。方法选择在本院经超声诊断为膝关节软骨损伤性关节炎的患者40例作为研究对象,根据病案号随机分为对照组和治疗组,各20例。对照组进行膝关节镜手术治疗,术后指导患者进行...目的观察吴门芪藤汤辅助治疗膝关节软骨损伤性关节炎的临床疗效。方法选择在本院经超声诊断为膝关节软骨损伤性关节炎的患者40例作为研究对象,根据病案号随机分为对照组和治疗组,各20例。对照组进行膝关节镜手术治疗,术后指导患者进行相应的功能锻炼及对症常规治疗;治疗组在对照组治疗方法的基础上给予吴门芪藤汤治疗,200 m L/次,2次/d。2周后比较2组的临床疗效,2组治疗前后的晨僵时间、视觉模拟评分法(VAS)评分及膝关节功能(Lysholm)评分,关节液中白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-3(MMP-3)含量。结果治疗组总有效率为100%,对照组为90%,2组比较差异有统计学意义(P<0.05);治疗后2组晨僵时间明显缩短,VAS评分明显降低,Lysholm评分明显升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组对晨僵时间及Lysholm评分的改善作用更显著(P<0.05);治疗后2组关节液中的TNF-α、IL-1及MMP-3含量均明显降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组IL-1及MMP-3含量降低更显著(P<0.05)。结论在膝关节镜手术基础上采用吴门芪藤汤治疗膝关节软骨损伤性关节炎,可以抑制患者关节积液中IL-1、MMP-3的过表达,改善患者膝关节功能,提高临床疗效,值得临床推广应用。展开更多
文摘AIM: To demonstrate the effect of Hewei-Decoction (Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori. METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs. Hewei-Decoction was taken by all the patients orally for 4 or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori.X2 test was used to compare the efficacy between H pylori-positive and negative cases, and to disclose the relationship between efficacy and eradication of H pylori. RESULTS: In patients with six different syndrome types, the efficacy of Hewei-Decoction was 91.67% (11/12), 92.86% (13/14), 97.22% (35/36), 87.50% (14/16), 75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14), 77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and 25.00% (1/4), respectively. The total efficacy was 91.11% (82/90), and the rate of highly efficacious was 60.00% (54/90). The eradication rate of H pylori was 67.86% (38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in H pylori-negative cases with the total effect of 96.43% vs 82.35% (P<0.05). In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pylori-existent cases with the total effect of 97.37% vs 72.22% (P<0.01). CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.
基金This case report was supported by the National Natural Science Foundation of China(No.81774146)Beijing Nova Program(No.xxjh2015A093 and No.Z1511000003150125).
文摘Objectives:Helicobacter pylori(H.pylori)infection is one of the most common infections,for which wellestablished medical treatments have been widely used,such as quadruple therapy and sequential therapy.However,some patients still suffer from the infection after multiple treatment.Traditional Chinese medicine(TCM)has been widely used to treat the H.pylori infection.Whether the combination of TCM therapy and antibiotic treatment is effective for these patients with repeated infection with H.pylori needs clinical observation.Methods:In this study,we reported two cases with refractory H.pylori infection.One is a 60-yearold Chinese woman with diagnoses of chronic atrophic gastritis and H.pylori infection,who has an uncomfortable feeling in her stomach with a poor appetite,depression and irregular defecations.The other is a Vietnamese woman aged 46,who had abdominal pain for 11 years.We treated the two patients with Chai Ping Decoction,combined with sequential therapy.Results:Both patients had pain relieved and H.pylori infection eradicated after treatment.Conclusion:TCM therapy may eliminate H.pylori infection well with sequential therapy.Based on the TCM theory,the patients who were diagnosed as spleen deficiency and dampness with abdominal uncomfortable symptoms could be well treated.
文摘目的观察吴门芪藤汤辅助治疗膝关节软骨损伤性关节炎的临床疗效。方法选择在本院经超声诊断为膝关节软骨损伤性关节炎的患者40例作为研究对象,根据病案号随机分为对照组和治疗组,各20例。对照组进行膝关节镜手术治疗,术后指导患者进行相应的功能锻炼及对症常规治疗;治疗组在对照组治疗方法的基础上给予吴门芪藤汤治疗,200 m L/次,2次/d。2周后比较2组的临床疗效,2组治疗前后的晨僵时间、视觉模拟评分法(VAS)评分及膝关节功能(Lysholm)评分,关节液中白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-3(MMP-3)含量。结果治疗组总有效率为100%,对照组为90%,2组比较差异有统计学意义(P<0.05);治疗后2组晨僵时间明显缩短,VAS评分明显降低,Lysholm评分明显升高,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组对晨僵时间及Lysholm评分的改善作用更显著(P<0.05);治疗后2组关节液中的TNF-α、IL-1及MMP-3含量均明显降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组IL-1及MMP-3含量降低更显著(P<0.05)。结论在膝关节镜手术基础上采用吴门芪藤汤治疗膝关节软骨损伤性关节炎,可以抑制患者关节积液中IL-1、MMP-3的过表达,改善患者膝关节功能,提高临床疗效,值得临床推广应用。
